Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2

Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral i...

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Autores principales: Yokoyama, Takashi, Nishimura, Tomoyasu, Uwamino, Yoshifumi, Kosaki, Kenjiro, Furusaki, Koichi, Onishi, Rumiko, Onodera, Takashi, Haritani, Makoto, Sugiura, Katsuaki, Kirisawa, Rikio, Hasegawa, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537736/
https://www.ncbi.nlm.nih.gov/pubmed/34683417
http://dx.doi.org/10.3390/microorganisms9102096
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author Yokoyama, Takashi
Nishimura, Tomoyasu
Uwamino, Yoshifumi
Kosaki, Kenjiro
Furusaki, Koichi
Onishi, Rumiko
Onodera, Takashi
Haritani, Makoto
Sugiura, Katsuaki
Kirisawa, Rikio
Hasegawa, Naoki
author_facet Yokoyama, Takashi
Nishimura, Tomoyasu
Uwamino, Yoshifumi
Kosaki, Kenjiro
Furusaki, Koichi
Onishi, Rumiko
Onodera, Takashi
Haritani, Makoto
Sugiura, Katsuaki
Kirisawa, Rikio
Hasegawa, Naoki
author_sort Yokoyama, Takashi
collection PubMed
description Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral infectivity decreased within 15 s, and the virucidal activity of CAC-717 at a 1:49 ratio was similar to that of ethanol disinfectant. CAC-717 neutralization eliminated this virucidal effect, indicating that the alkaline condition of CAC-717 is important for virus inactivation and is an indicator of its mesoscopic structure and virucidal activity. The virucidal effect was observed in the presence of organic matter (bovine serum albumin). CAC-717 is a non-invasive and non-flammable substance with a low environmental burden, and its usefulness as a novel disinfectant has been confirmed.
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spelling pubmed-85377362021-10-24 Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2 Yokoyama, Takashi Nishimura, Tomoyasu Uwamino, Yoshifumi Kosaki, Kenjiro Furusaki, Koichi Onishi, Rumiko Onodera, Takashi Haritani, Makoto Sugiura, Katsuaki Kirisawa, Rikio Hasegawa, Naoki Microorganisms Communication Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral infectivity decreased within 15 s, and the virucidal activity of CAC-717 at a 1:49 ratio was similar to that of ethanol disinfectant. CAC-717 neutralization eliminated this virucidal effect, indicating that the alkaline condition of CAC-717 is important for virus inactivation and is an indicator of its mesoscopic structure and virucidal activity. The virucidal effect was observed in the presence of organic matter (bovine serum albumin). CAC-717 is a non-invasive and non-flammable substance with a low environmental burden, and its usefulness as a novel disinfectant has been confirmed. MDPI 2021-10-04 /pmc/articles/PMC8537736/ /pubmed/34683417 http://dx.doi.org/10.3390/microorganisms9102096 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Yokoyama, Takashi
Nishimura, Tomoyasu
Uwamino, Yoshifumi
Kosaki, Kenjiro
Furusaki, Koichi
Onishi, Rumiko
Onodera, Takashi
Haritani, Makoto
Sugiura, Katsuaki
Kirisawa, Rikio
Hasegawa, Naoki
Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2
title Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2
title_full Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2
title_fullStr Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2
title_full_unstemmed Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2
title_short Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2
title_sort virucidal effect of the mesoscopic structure of cac-717 on severe acute respiratory syndrome coronavirus-2
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537736/
https://www.ncbi.nlm.nih.gov/pubmed/34683417
http://dx.doi.org/10.3390/microorganisms9102096
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