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Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study

Intestinal dysbiosis plays a crucial role in the development of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). The importance of bacterial metabolites, such as short-chain fatty acids (SCFAs), succinic and lactic acids, as well as environmental factors...

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Autores principales: Kaczmarczyk, Olga, Dąbek-Drobny, Agnieszka, Woźniakiewicz, Michał, Paśko, Paweł, Dobrowolska-Iwanek, Justyna, Woźniakiewicz, Aneta, Piątek-Guziewicz, Agnieszka, Zagrodzki, Paweł, Mach, Tomasz, Zwolińska-Wcisło, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537748/
https://www.ncbi.nlm.nih.gov/pubmed/34682823
http://dx.doi.org/10.3390/jcm10204701
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author Kaczmarczyk, Olga
Dąbek-Drobny, Agnieszka
Woźniakiewicz, Michał
Paśko, Paweł
Dobrowolska-Iwanek, Justyna
Woźniakiewicz, Aneta
Piątek-Guziewicz, Agnieszka
Zagrodzki, Paweł
Mach, Tomasz
Zwolińska-Wcisło, Małgorzata
author_facet Kaczmarczyk, Olga
Dąbek-Drobny, Agnieszka
Woźniakiewicz, Michał
Paśko, Paweł
Dobrowolska-Iwanek, Justyna
Woźniakiewicz, Aneta
Piątek-Guziewicz, Agnieszka
Zagrodzki, Paweł
Mach, Tomasz
Zwolińska-Wcisło, Małgorzata
author_sort Kaczmarczyk, Olga
collection PubMed
description Intestinal dysbiosis plays a crucial role in the development of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). The importance of bacterial metabolites, such as short-chain fatty acids (SCFAs), succinic and lactic acids, as well as environmental factors that affect their production in the course of IBD, remains unclear. The aim of this study was to evaluate a profile of organic acids in the stool of CD and UC patients with different disease activity. We assessed a correlation between used medications, patient’s diet, and SCFA levels. A total of 35 adult patients were included in the study. We did not observe significant differences in the levels of organic acids between the CD and UC groups, irrespective of disease activity, and a control group. However, propionic acid levels were higher in IBD patients who received trimebutine vs. those who did not (p = 0.031). Higher isobutyric acid levels were observed in patients treated with biological drugs compared with those without such treatment (p = 0.014). No significant correlations were found between organic acid levels and the frequency of dietary fiber consumption. Our results reveal a new link between medication use and organic acid levels in patients with IBD.
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spelling pubmed-85377482021-10-24 Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study Kaczmarczyk, Olga Dąbek-Drobny, Agnieszka Woźniakiewicz, Michał Paśko, Paweł Dobrowolska-Iwanek, Justyna Woźniakiewicz, Aneta Piątek-Guziewicz, Agnieszka Zagrodzki, Paweł Mach, Tomasz Zwolińska-Wcisło, Małgorzata J Clin Med Article Intestinal dysbiosis plays a crucial role in the development of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). The importance of bacterial metabolites, such as short-chain fatty acids (SCFAs), succinic and lactic acids, as well as environmental factors that affect their production in the course of IBD, remains unclear. The aim of this study was to evaluate a profile of organic acids in the stool of CD and UC patients with different disease activity. We assessed a correlation between used medications, patient’s diet, and SCFA levels. A total of 35 adult patients were included in the study. We did not observe significant differences in the levels of organic acids between the CD and UC groups, irrespective of disease activity, and a control group. However, propionic acid levels were higher in IBD patients who received trimebutine vs. those who did not (p = 0.031). Higher isobutyric acid levels were observed in patients treated with biological drugs compared with those without such treatment (p = 0.014). No significant correlations were found between organic acid levels and the frequency of dietary fiber consumption. Our results reveal a new link between medication use and organic acid levels in patients with IBD. MDPI 2021-10-13 /pmc/articles/PMC8537748/ /pubmed/34682823 http://dx.doi.org/10.3390/jcm10204701 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kaczmarczyk, Olga
Dąbek-Drobny, Agnieszka
Woźniakiewicz, Michał
Paśko, Paweł
Dobrowolska-Iwanek, Justyna
Woźniakiewicz, Aneta
Piątek-Guziewicz, Agnieszka
Zagrodzki, Paweł
Mach, Tomasz
Zwolińska-Wcisło, Małgorzata
Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study
title Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study
title_full Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study
title_fullStr Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study
title_full_unstemmed Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study
title_short Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study
title_sort fecal levels of lactic, succinic and short-chain fatty acids in patients with ulcerative colitis and crohn disease: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537748/
https://www.ncbi.nlm.nih.gov/pubmed/34682823
http://dx.doi.org/10.3390/jcm10204701
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