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Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis

The child microbiome, including gut and skin communities, is shaped by a multitude of factors, and breastfeeding is one of the most essential. Food allergy (FA) and atopic dermatitis (AD) are among the most common diseases in pediatrics, with the prevalence of each up to 6% and 20%, respectively. Th...

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Autores principales: Gołębiewski, Marcin, Łoś-Rycharska, Ewa, Sikora, Marcin, Grzybowski, Tomasz, Gorzkiewicz, Marta, Krogulska, Aneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537811/
https://www.ncbi.nlm.nih.gov/pubmed/34684601
http://dx.doi.org/10.3390/nu13103600
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author Gołębiewski, Marcin
Łoś-Rycharska, Ewa
Sikora, Marcin
Grzybowski, Tomasz
Gorzkiewicz, Marta
Krogulska, Aneta
author_facet Gołębiewski, Marcin
Łoś-Rycharska, Ewa
Sikora, Marcin
Grzybowski, Tomasz
Gorzkiewicz, Marta
Krogulska, Aneta
author_sort Gołębiewski, Marcin
collection PubMed
description The child microbiome, including gut and skin communities, is shaped by a multitude of factors, and breastfeeding is one of the most essential. Food allergy (FA) and atopic dermatitis (AD) are among the most common diseases in pediatrics, with the prevalence of each up to 6% and 20%, respectively. Therefore, we aimed at finding differences between the fecal and skin microbiomes of FA and AD patients in the context of breastfeeding, by means of the Illumina sequencing of 16S rRNA gene fragment libraries amplified from the total DNA isolated from samples collected from allergic and healthy infants. We also analyzed milk samples from the mothers of the examined children and searched for patterns of incidence suggesting milk influence on an infant’s allergy status. Here we show that a mother’s milk influences her child’s fecal and skin microbiomes and identify Acinetobacter as the taxon whose abundance is correlated with milk and child-derived samples. We demonstrate that breastfeeding makes allergic children's fecal and skin communities more similar to those of healthy infants than in the case of formula-feeding. We also identify signature taxa that might be important in maintaining health or allergy development.
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spelling pubmed-85378112021-10-24 Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis Gołębiewski, Marcin Łoś-Rycharska, Ewa Sikora, Marcin Grzybowski, Tomasz Gorzkiewicz, Marta Krogulska, Aneta Nutrients Article The child microbiome, including gut and skin communities, is shaped by a multitude of factors, and breastfeeding is one of the most essential. Food allergy (FA) and atopic dermatitis (AD) are among the most common diseases in pediatrics, with the prevalence of each up to 6% and 20%, respectively. Therefore, we aimed at finding differences between the fecal and skin microbiomes of FA and AD patients in the context of breastfeeding, by means of the Illumina sequencing of 16S rRNA gene fragment libraries amplified from the total DNA isolated from samples collected from allergic and healthy infants. We also analyzed milk samples from the mothers of the examined children and searched for patterns of incidence suggesting milk influence on an infant’s allergy status. Here we show that a mother’s milk influences her child’s fecal and skin microbiomes and identify Acinetobacter as the taxon whose abundance is correlated with milk and child-derived samples. We demonstrate that breastfeeding makes allergic children's fecal and skin communities more similar to those of healthy infants than in the case of formula-feeding. We also identify signature taxa that might be important in maintaining health or allergy development. MDPI 2021-10-14 /pmc/articles/PMC8537811/ /pubmed/34684601 http://dx.doi.org/10.3390/nu13103600 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gołębiewski, Marcin
Łoś-Rycharska, Ewa
Sikora, Marcin
Grzybowski, Tomasz
Gorzkiewicz, Marta
Krogulska, Aneta
Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
title Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
title_full Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
title_fullStr Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
title_full_unstemmed Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
title_short Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
title_sort mother’s milk microbiome shaping fecal and skin microbiota in infants with food allergy and atopic dermatitis: a pilot analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537811/
https://www.ncbi.nlm.nih.gov/pubmed/34684601
http://dx.doi.org/10.3390/nu13103600
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