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Extramammary Paget’s Disease of the Vulva: Report of Two Cases

Extramammary Paget’s disease is a rare condition, affecting 6.5% of all patients with Paget’s disease. The most common extramammary site is the vulvar area. Although diagnosis in some patients is difficult to set, early diagnosis is of high importance in order to detect the irreversible progression...

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Autores principales: Kosmidis, Christoforos S., Sevva, Christina, Roulia, Panagiota, Koulouris, Charilaos, Varsamis, Nikolaos, Koimtzis, Georgios, Theodorou, Vasiliki, Mystakidou, Chrysi Maria, Georgakoudi, Eleni, Anthimidis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537848/
https://www.ncbi.nlm.nih.gov/pubmed/34684065
http://dx.doi.org/10.3390/medicina57101029
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author Kosmidis, Christoforos S.
Sevva, Christina
Roulia, Panagiota
Koulouris, Charilaos
Varsamis, Nikolaos
Koimtzis, Georgios
Theodorou, Vasiliki
Mystakidou, Chrysi Maria
Georgakoudi, Eleni
Anthimidis, Georgios
author_facet Kosmidis, Christoforos S.
Sevva, Christina
Roulia, Panagiota
Koulouris, Charilaos
Varsamis, Nikolaos
Koimtzis, Georgios
Theodorou, Vasiliki
Mystakidou, Chrysi Maria
Georgakoudi, Eleni
Anthimidis, Georgios
author_sort Kosmidis, Christoforos S.
collection PubMed
description Extramammary Paget’s disease is a rare condition, affecting 6.5% of all patients with Paget’s disease. The most common extramammary site is the vulvar area. Although diagnosis in some patients is difficult to set, early diagnosis is of high importance in order to detect the irreversible progression of the lesion early and prevent distant metastasis. An 89-year-old female and a 69-year-old female presented within three months with an eczematous lesion with leukoplakia in the vulva. The incisional biopsy of the skin revealed extramammary Paget’s disease. Both patients underwent a surgical wide local excision of the lesion and the specimens were sent for histopathological examination. Extramammary Paget’s disease has a high potential for distant malignancies and local recurrence, dictating that surgical excision is the most efficient treatment. The rareness of the condition and the diagnostic difficulties underline the need for early skin biopsy, which is the most efficient diagnostic tool.
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spelling pubmed-85378482021-10-24 Extramammary Paget’s Disease of the Vulva: Report of Two Cases Kosmidis, Christoforos S. Sevva, Christina Roulia, Panagiota Koulouris, Charilaos Varsamis, Nikolaos Koimtzis, Georgios Theodorou, Vasiliki Mystakidou, Chrysi Maria Georgakoudi, Eleni Anthimidis, Georgios Medicina (Kaunas) Case Report Extramammary Paget’s disease is a rare condition, affecting 6.5% of all patients with Paget’s disease. The most common extramammary site is the vulvar area. Although diagnosis in some patients is difficult to set, early diagnosis is of high importance in order to detect the irreversible progression of the lesion early and prevent distant metastasis. An 89-year-old female and a 69-year-old female presented within three months with an eczematous lesion with leukoplakia in the vulva. The incisional biopsy of the skin revealed extramammary Paget’s disease. Both patients underwent a surgical wide local excision of the lesion and the specimens were sent for histopathological examination. Extramammary Paget’s disease has a high potential for distant malignancies and local recurrence, dictating that surgical excision is the most efficient treatment. The rareness of the condition and the diagnostic difficulties underline the need for early skin biopsy, which is the most efficient diagnostic tool. MDPI 2021-09-27 /pmc/articles/PMC8537848/ /pubmed/34684065 http://dx.doi.org/10.3390/medicina57101029 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kosmidis, Christoforos S.
Sevva, Christina
Roulia, Panagiota
Koulouris, Charilaos
Varsamis, Nikolaos
Koimtzis, Georgios
Theodorou, Vasiliki
Mystakidou, Chrysi Maria
Georgakoudi, Eleni
Anthimidis, Georgios
Extramammary Paget’s Disease of the Vulva: Report of Two Cases
title Extramammary Paget’s Disease of the Vulva: Report of Two Cases
title_full Extramammary Paget’s Disease of the Vulva: Report of Two Cases
title_fullStr Extramammary Paget’s Disease of the Vulva: Report of Two Cases
title_full_unstemmed Extramammary Paget’s Disease of the Vulva: Report of Two Cases
title_short Extramammary Paget’s Disease of the Vulva: Report of Two Cases
title_sort extramammary paget’s disease of the vulva: report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537848/
https://www.ncbi.nlm.nih.gov/pubmed/34684065
http://dx.doi.org/10.3390/medicina57101029
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