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Extramammary Paget’s Disease of the Vulva: Report of Two Cases
Extramammary Paget’s disease is a rare condition, affecting 6.5% of all patients with Paget’s disease. The most common extramammary site is the vulvar area. Although diagnosis in some patients is difficult to set, early diagnosis is of high importance in order to detect the irreversible progression...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537848/ https://www.ncbi.nlm.nih.gov/pubmed/34684065 http://dx.doi.org/10.3390/medicina57101029 |
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author | Kosmidis, Christoforos S. Sevva, Christina Roulia, Panagiota Koulouris, Charilaos Varsamis, Nikolaos Koimtzis, Georgios Theodorou, Vasiliki Mystakidou, Chrysi Maria Georgakoudi, Eleni Anthimidis, Georgios |
author_facet | Kosmidis, Christoforos S. Sevva, Christina Roulia, Panagiota Koulouris, Charilaos Varsamis, Nikolaos Koimtzis, Georgios Theodorou, Vasiliki Mystakidou, Chrysi Maria Georgakoudi, Eleni Anthimidis, Georgios |
author_sort | Kosmidis, Christoforos S. |
collection | PubMed |
description | Extramammary Paget’s disease is a rare condition, affecting 6.5% of all patients with Paget’s disease. The most common extramammary site is the vulvar area. Although diagnosis in some patients is difficult to set, early diagnosis is of high importance in order to detect the irreversible progression of the lesion early and prevent distant metastasis. An 89-year-old female and a 69-year-old female presented within three months with an eczematous lesion with leukoplakia in the vulva. The incisional biopsy of the skin revealed extramammary Paget’s disease. Both patients underwent a surgical wide local excision of the lesion and the specimens were sent for histopathological examination. Extramammary Paget’s disease has a high potential for distant malignancies and local recurrence, dictating that surgical excision is the most efficient treatment. The rareness of the condition and the diagnostic difficulties underline the need for early skin biopsy, which is the most efficient diagnostic tool. |
format | Online Article Text |
id | pubmed-8537848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85378482021-10-24 Extramammary Paget’s Disease of the Vulva: Report of Two Cases Kosmidis, Christoforos S. Sevva, Christina Roulia, Panagiota Koulouris, Charilaos Varsamis, Nikolaos Koimtzis, Georgios Theodorou, Vasiliki Mystakidou, Chrysi Maria Georgakoudi, Eleni Anthimidis, Georgios Medicina (Kaunas) Case Report Extramammary Paget’s disease is a rare condition, affecting 6.5% of all patients with Paget’s disease. The most common extramammary site is the vulvar area. Although diagnosis in some patients is difficult to set, early diagnosis is of high importance in order to detect the irreversible progression of the lesion early and prevent distant metastasis. An 89-year-old female and a 69-year-old female presented within three months with an eczematous lesion with leukoplakia in the vulva. The incisional biopsy of the skin revealed extramammary Paget’s disease. Both patients underwent a surgical wide local excision of the lesion and the specimens were sent for histopathological examination. Extramammary Paget’s disease has a high potential for distant malignancies and local recurrence, dictating that surgical excision is the most efficient treatment. The rareness of the condition and the diagnostic difficulties underline the need for early skin biopsy, which is the most efficient diagnostic tool. MDPI 2021-09-27 /pmc/articles/PMC8537848/ /pubmed/34684065 http://dx.doi.org/10.3390/medicina57101029 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Kosmidis, Christoforos S. Sevva, Christina Roulia, Panagiota Koulouris, Charilaos Varsamis, Nikolaos Koimtzis, Georgios Theodorou, Vasiliki Mystakidou, Chrysi Maria Georgakoudi, Eleni Anthimidis, Georgios Extramammary Paget’s Disease of the Vulva: Report of Two Cases |
title | Extramammary Paget’s Disease of the Vulva: Report of Two Cases |
title_full | Extramammary Paget’s Disease of the Vulva: Report of Two Cases |
title_fullStr | Extramammary Paget’s Disease of the Vulva: Report of Two Cases |
title_full_unstemmed | Extramammary Paget’s Disease of the Vulva: Report of Two Cases |
title_short | Extramammary Paget’s Disease of the Vulva: Report of Two Cases |
title_sort | extramammary paget’s disease of the vulva: report of two cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537848/ https://www.ncbi.nlm.nih.gov/pubmed/34684065 http://dx.doi.org/10.3390/medicina57101029 |
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