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Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomiz...

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Autores principales: Kołodziejczyk-Nowotarska, Alicja, Bokiniec, Renata, Seliga-Siwecka, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537871/
https://www.ncbi.nlm.nih.gov/pubmed/34684442
http://dx.doi.org/10.3390/nu13103442
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author Kołodziejczyk-Nowotarska, Alicja
Bokiniec, Renata
Seliga-Siwecka, Joanna
author_facet Kołodziejczyk-Nowotarska, Alicja
Bokiniec, Renata
Seliga-Siwecka, Joanna
author_sort Kołodziejczyk-Nowotarska, Alicja
collection PubMed
description Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n = 55; approximately 800–1000 IU from combined sources) or monitored therapy (n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (>90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20–80 ng/mL) at 52 weeks of PCA (p = 0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose.
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spelling pubmed-85378712021-10-24 Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial Kołodziejczyk-Nowotarska, Alicja Bokiniec, Renata Seliga-Siwecka, Joanna Nutrients Article Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n = 55; approximately 800–1000 IU from combined sources) or monitored therapy (n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (>90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20–80 ng/mL) at 52 weeks of PCA (p = 0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose. MDPI 2021-09-28 /pmc/articles/PMC8537871/ /pubmed/34684442 http://dx.doi.org/10.3390/nu13103442 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kołodziejczyk-Nowotarska, Alicja
Bokiniec, Renata
Seliga-Siwecka, Joanna
Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial
title Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial
title_full Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial
title_fullStr Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial
title_full_unstemmed Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial
title_short Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial
title_sort monitored supplementation of vitamin d in preterm infants: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537871/
https://www.ncbi.nlm.nih.gov/pubmed/34684442
http://dx.doi.org/10.3390/nu13103442
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