Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol

A library of sulfonate and sulfonamide derivatives of Resveratrol was synthesized and tested for its aromatase inhibitory potential. Interestingly, sulfonate derivatives were found to be more active than sulfonamide bioisosteres with IC(50) values in the low micromolar range. The sulfonate analogues...

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Detalles Bibliográficos
Autores principales: Fantacuzzi, Marialuigia, Gallorini, Marialucia, Gambacorta, Nicola, Ammazzalorso, Alessandra, Aturki, Zeineb, Balaha, Marwa, Carradori, Simone, Giampietro, Letizia, Maccallini, Cristina, Cataldi, Amelia, Nicolotti, Orazio, Amoroso, Rosa, De Filippis, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537897/
https://www.ncbi.nlm.nih.gov/pubmed/34681208
http://dx.doi.org/10.3390/ph14100984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537897/
https://www.ncbi.nlm.nih.gov/pubmed/34681208
http://dx.doi.org/10.3390/ph14100984

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