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In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care

Despite significant advances in the management of heart failure (HF), further improvement in the outcome of this chronic and progressive disease is still considered a major unmet need. Recurrent hospitalizations due to decompensated HF frequently occur, resulting in increased morbidity and mortality...

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Autores principales: Nachman, Dean, Rahamim, Eldad, Kolben, Yotam, Mengesha, Bethlehem, Elbaz-Greener, Gabby, Amir, Offer, Asleh, Rabea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537939/
https://www.ncbi.nlm.nih.gov/pubmed/34682813
http://dx.doi.org/10.3390/jcm10204692
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author Nachman, Dean
Rahamim, Eldad
Kolben, Yotam
Mengesha, Bethlehem
Elbaz-Greener, Gabby
Amir, Offer
Asleh, Rabea
author_facet Nachman, Dean
Rahamim, Eldad
Kolben, Yotam
Mengesha, Bethlehem
Elbaz-Greener, Gabby
Amir, Offer
Asleh, Rabea
author_sort Nachman, Dean
collection PubMed
description Despite significant advances in the management of heart failure (HF), further improvement in the outcome of this chronic and progressive disease is still considered a major unmet need. Recurrent hospitalizations due to decompensated HF frequently occur, resulting in increased morbidity and mortality rates. Past attempts at early detection of clinical deterioration were mainly based on monitoring of signs and symptoms of HF exacerbation, which have mostly given disappointing results. Extensive research of the pathophysiology of HF decompensation has indicated that hemodynamic alterations start days prior to clinical manifestation. Novel technologies aim to monitor these minute hemodynamic changes, allowing time for therapeutic interventions to prevent hemodynamic derangement and HF exacerbation. The latest noticeable advancements include assessment of lung fluid volume, wearable devices with integrated sensors, and microelectromechanical systems-based implantable devices for continuous measurement of cardiac filling pressures. This manuscript will review the rationale for monitoring HF patients and discuss previous and ongoing attempts to develop clinically meaningful monitoring devices to improve daily HF health care, with particular emphasis on the recent advances and clinical trials relevant to this evolving field.
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spelling pubmed-85379392021-10-24 In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care Nachman, Dean Rahamim, Eldad Kolben, Yotam Mengesha, Bethlehem Elbaz-Greener, Gabby Amir, Offer Asleh, Rabea J Clin Med Review Despite significant advances in the management of heart failure (HF), further improvement in the outcome of this chronic and progressive disease is still considered a major unmet need. Recurrent hospitalizations due to decompensated HF frequently occur, resulting in increased morbidity and mortality rates. Past attempts at early detection of clinical deterioration were mainly based on monitoring of signs and symptoms of HF exacerbation, which have mostly given disappointing results. Extensive research of the pathophysiology of HF decompensation has indicated that hemodynamic alterations start days prior to clinical manifestation. Novel technologies aim to monitor these minute hemodynamic changes, allowing time for therapeutic interventions to prevent hemodynamic derangement and HF exacerbation. The latest noticeable advancements include assessment of lung fluid volume, wearable devices with integrated sensors, and microelectromechanical systems-based implantable devices for continuous measurement of cardiac filling pressures. This manuscript will review the rationale for monitoring HF patients and discuss previous and ongoing attempts to develop clinically meaningful monitoring devices to improve daily HF health care, with particular emphasis on the recent advances and clinical trials relevant to this evolving field. MDPI 2021-10-13 /pmc/articles/PMC8537939/ /pubmed/34682813 http://dx.doi.org/10.3390/jcm10204692 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nachman, Dean
Rahamim, Eldad
Kolben, Yotam
Mengesha, Bethlehem
Elbaz-Greener, Gabby
Amir, Offer
Asleh, Rabea
In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care
title In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care
title_full In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care
title_fullStr In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care
title_full_unstemmed In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care
title_short In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care
title_sort in search of clinical impact: advanced monitoring technologies in daily heart failure care
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537939/
https://www.ncbi.nlm.nih.gov/pubmed/34682813
http://dx.doi.org/10.3390/jcm10204692
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