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Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro

We report the in vitro efficacy of ion-channel inhibitors amantadine, memantine and rimantadine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In VeroE6 cells, rimantadine was most potent followed by memantine and amantadine (50% effective concentrations: 36, 80 and 116 µM, re...

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Detalles Bibliográficos
Autores principales:	Zhou, Yuyong, Gammeltoft, Karen A., Galli, Andrea, Offersgaard, Anna, Fahnøe, Ulrik, Ramirez, Santseharay, Bukh, Jens, Gottwein, Judith M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537953/ https://www.ncbi.nlm.nih.gov/pubmed/34696509 http://dx.doi.org/10.3390/v13102082

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