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Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms

Tryptophanase encoded by the gene tnaA is a pyridoxal phosphate-dependent enzyme that catalyses the conversion of tryptophan to indole, which is commonly used as an intra- and interspecies signalling molecule, particularly by microbes. However, the production of indole is rare in eukaryotic organism...

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Autores principales: Boya, Bharath Reddy, Kumar, Prasun, Lee, Jin-Hyung, Lee, Jintae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537960/
https://www.ncbi.nlm.nih.gov/pubmed/34683477
http://dx.doi.org/10.3390/microorganisms9102156
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author Boya, Bharath Reddy
Kumar, Prasun
Lee, Jin-Hyung
Lee, Jintae
author_facet Boya, Bharath Reddy
Kumar, Prasun
Lee, Jin-Hyung
Lee, Jintae
author_sort Boya, Bharath Reddy
collection PubMed
description Tryptophanase encoded by the gene tnaA is a pyridoxal phosphate-dependent enzyme that catalyses the conversion of tryptophan to indole, which is commonly used as an intra- and interspecies signalling molecule, particularly by microbes. However, the production of indole is rare in eukaryotic organisms. A nucleotide and protein database search revealed tnaA is commonly reported in various Gram-negative bacteria, but that only a few Gram-positive bacteria and archaea possess the gene. The presence of tnaA in eukaryotes, particularly protozoans and marine organisms, demonstrates the importance of this gene in the animal kingdom. Here, we document the distribution of tnaA and its acquisition and expansion among different taxonomic groups, many of which are usually categorized as non-indole producers. This study provides an opportunity to understand the intriguing role played by tnaA, and its distribution among various types of organisms.
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spelling pubmed-85379602021-10-24 Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms Boya, Bharath Reddy Kumar, Prasun Lee, Jin-Hyung Lee, Jintae Microorganisms Article Tryptophanase encoded by the gene tnaA is a pyridoxal phosphate-dependent enzyme that catalyses the conversion of tryptophan to indole, which is commonly used as an intra- and interspecies signalling molecule, particularly by microbes. However, the production of indole is rare in eukaryotic organisms. A nucleotide and protein database search revealed tnaA is commonly reported in various Gram-negative bacteria, but that only a few Gram-positive bacteria and archaea possess the gene. The presence of tnaA in eukaryotes, particularly protozoans and marine organisms, demonstrates the importance of this gene in the animal kingdom. Here, we document the distribution of tnaA and its acquisition and expansion among different taxonomic groups, many of which are usually categorized as non-indole producers. This study provides an opportunity to understand the intriguing role played by tnaA, and its distribution among various types of organisms. MDPI 2021-10-15 /pmc/articles/PMC8537960/ /pubmed/34683477 http://dx.doi.org/10.3390/microorganisms9102156 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boya, Bharath Reddy
Kumar, Prasun
Lee, Jin-Hyung
Lee, Jintae
Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms
title Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms
title_full Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms
title_fullStr Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms
title_full_unstemmed Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms
title_short Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms
title_sort diversity of the tryptophanase gene and its evolutionary implications in living organisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537960/
https://www.ncbi.nlm.nih.gov/pubmed/34683477
http://dx.doi.org/10.3390/microorganisms9102156
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