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School-Level Variation in Coverage of Co-Administered dTpa and HPV Dose 1 in Three Australian States

Background: Australian adolescents are routinely offered HPV and dTpa (diphtheria, tetanus, pertussis) vaccines simultaneously in the secondary school vaccination program. We identified schools where HPV initiation was lower than dTpa coverage and associated school-level factors across three states....

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Autores principales: Vujovich-Dunn, Cassandra, Skinner, Susan Rachel, Brotherton, Julia, Wand, Handan, Sisnowski, Jana, Lorch, Rebecca, Veitch, Mark, Sheppeard, Vicky, Effler, Paul, Gidding, Heather, Venn, Alison, Davies, Cristyn, Hocking, Jane, Whop, Lisa J., Leask, Julie, Canfell, Karen, Sanci, Lena, Smith, Megan, Kang, Melissa, Temple-Smith, Meredith, Kidd, Michael, Burns, Sharyn, Selvey, Linda, Meijer, Dennis, Ennis, Sonya, Thomson, Chloe A., Lane, Nikole, Kaldor, John, Guy, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537995/
https://www.ncbi.nlm.nih.gov/pubmed/34696310
http://dx.doi.org/10.3390/vaccines9101202
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author Vujovich-Dunn, Cassandra
Skinner, Susan Rachel
Brotherton, Julia
Wand, Handan
Sisnowski, Jana
Lorch, Rebecca
Veitch, Mark
Sheppeard, Vicky
Effler, Paul
Gidding, Heather
Venn, Alison
Davies, Cristyn
Hocking, Jane
Whop, Lisa J.
Leask, Julie
Canfell, Karen
Sanci, Lena
Smith, Megan
Kang, Melissa
Temple-Smith, Meredith
Kidd, Michael
Burns, Sharyn
Selvey, Linda
Meijer, Dennis
Ennis, Sonya
Thomson, Chloe A.
Lane, Nikole
Kaldor, John
Guy, Rebecca
author_facet Vujovich-Dunn, Cassandra
Skinner, Susan Rachel
Brotherton, Julia
Wand, Handan
Sisnowski, Jana
Lorch, Rebecca
Veitch, Mark
Sheppeard, Vicky
Effler, Paul
Gidding, Heather
Venn, Alison
Davies, Cristyn
Hocking, Jane
Whop, Lisa J.
Leask, Julie
Canfell, Karen
Sanci, Lena
Smith, Megan
Kang, Melissa
Temple-Smith, Meredith
Kidd, Michael
Burns, Sharyn
Selvey, Linda
Meijer, Dennis
Ennis, Sonya
Thomson, Chloe A.
Lane, Nikole
Kaldor, John
Guy, Rebecca
author_sort Vujovich-Dunn, Cassandra
collection PubMed
description Background: Australian adolescents are routinely offered HPV and dTpa (diphtheria, tetanus, pertussis) vaccines simultaneously in the secondary school vaccination program. We identified schools where HPV initiation was lower than dTpa coverage and associated school-level factors across three states. Methods: HPV vaccination initiation rates and dTpa vaccination coverage in 2016 were calculated using vaccine databases and school enrolment data. A multivariate analysis assessed sociodemographic and school-level factors associated with HPV initiation being >5% absolute lower than dTpa coverage. Results: Of 1280 schools included, the median school-level HPV initiation rate was 85% (interquartile range (IQR):75–90%) and the median dTpa coverage was 86% (IQR:75–92%). Nearly a quarter (24%) of all schools had HPV vaccination initiation >5% lower than dTpa coverage and 11 % had >10% difference. School-level factors independently associated with >5% difference were remote schools (aOR:3.5, 95% CI = 1.7–7.2) and schools in major cities (aOR:1.8, 95% CI = 1.0–3.0), small schools (aOR:3.3, 95% CI = 2.3–5.7), higher socioeconomic advantage (aOR:1.7, 95% CI = 1.1–2.6), and lower proportions of Language-background-other-than-English (aOR:1.9, 95% CI = 1.2–3.0). Conclusion: The results identified a quarter of schools had lower HPV than dTpa initiation coverage, which may indicate HPV vaccine hesitancy, and the difference was more likely in socioeconomically advantaged schools. As hesitancy is context specific, it is important to understand the potential drivers of hesitancy and future research needs to understand the reasons driving differential uptake.
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spelling pubmed-85379952021-10-24 School-Level Variation in Coverage of Co-Administered dTpa and HPV Dose 1 in Three Australian States Vujovich-Dunn, Cassandra Skinner, Susan Rachel Brotherton, Julia Wand, Handan Sisnowski, Jana Lorch, Rebecca Veitch, Mark Sheppeard, Vicky Effler, Paul Gidding, Heather Venn, Alison Davies, Cristyn Hocking, Jane Whop, Lisa J. Leask, Julie Canfell, Karen Sanci, Lena Smith, Megan Kang, Melissa Temple-Smith, Meredith Kidd, Michael Burns, Sharyn Selvey, Linda Meijer, Dennis Ennis, Sonya Thomson, Chloe A. Lane, Nikole Kaldor, John Guy, Rebecca Vaccines (Basel) Article Background: Australian adolescents are routinely offered HPV and dTpa (diphtheria, tetanus, pertussis) vaccines simultaneously in the secondary school vaccination program. We identified schools where HPV initiation was lower than dTpa coverage and associated school-level factors across three states. Methods: HPV vaccination initiation rates and dTpa vaccination coverage in 2016 were calculated using vaccine databases and school enrolment data. A multivariate analysis assessed sociodemographic and school-level factors associated with HPV initiation being >5% absolute lower than dTpa coverage. Results: Of 1280 schools included, the median school-level HPV initiation rate was 85% (interquartile range (IQR):75–90%) and the median dTpa coverage was 86% (IQR:75–92%). Nearly a quarter (24%) of all schools had HPV vaccination initiation >5% lower than dTpa coverage and 11 % had >10% difference. School-level factors independently associated with >5% difference were remote schools (aOR:3.5, 95% CI = 1.7–7.2) and schools in major cities (aOR:1.8, 95% CI = 1.0–3.0), small schools (aOR:3.3, 95% CI = 2.3–5.7), higher socioeconomic advantage (aOR:1.7, 95% CI = 1.1–2.6), and lower proportions of Language-background-other-than-English (aOR:1.9, 95% CI = 1.2–3.0). Conclusion: The results identified a quarter of schools had lower HPV than dTpa initiation coverage, which may indicate HPV vaccine hesitancy, and the difference was more likely in socioeconomically advantaged schools. As hesitancy is context specific, it is important to understand the potential drivers of hesitancy and future research needs to understand the reasons driving differential uptake. MDPI 2021-10-19 /pmc/articles/PMC8537995/ /pubmed/34696310 http://dx.doi.org/10.3390/vaccines9101202 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vujovich-Dunn, Cassandra
Skinner, Susan Rachel
Brotherton, Julia
Wand, Handan
Sisnowski, Jana
Lorch, Rebecca
Veitch, Mark
Sheppeard, Vicky
Effler, Paul
Gidding, Heather
Venn, Alison
Davies, Cristyn
Hocking, Jane
Whop, Lisa J.
Leask, Julie
Canfell, Karen
Sanci, Lena
Smith, Megan
Kang, Melissa
Temple-Smith, Meredith
Kidd, Michael
Burns, Sharyn
Selvey, Linda
Meijer, Dennis
Ennis, Sonya
Thomson, Chloe A.
Lane, Nikole
Kaldor, John
Guy, Rebecca
School-Level Variation in Coverage of Co-Administered dTpa and HPV Dose 1 in Three Australian States
title School-Level Variation in Coverage of Co-Administered dTpa and HPV Dose 1 in Three Australian States
title_full School-Level Variation in Coverage of Co-Administered dTpa and HPV Dose 1 in Three Australian States
title_fullStr School-Level Variation in Coverage of Co-Administered dTpa and HPV Dose 1 in Three Australian States
title_full_unstemmed School-Level Variation in Coverage of Co-Administered dTpa and HPV Dose 1 in Three Australian States
title_short School-Level Variation in Coverage of Co-Administered dTpa and HPV Dose 1 in Three Australian States
title_sort school-level variation in coverage of co-administered dtpa and hpv dose 1 in three australian states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537995/
https://www.ncbi.nlm.nih.gov/pubmed/34696310
http://dx.doi.org/10.3390/vaccines9101202
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