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Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients
Background and objectives: This study aimed to evaluate prognostic factors for post-recurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All pa...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538010/ https://www.ncbi.nlm.nih.gov/pubmed/34684145 http://dx.doi.org/10.3390/medicina57101108 |
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author | Nikolic, Neda Radosavljevic, Davorin Gavrilovic, Dusica Nikolic, Vladimir Stanic, Nemanja Spasic, Jelena Cacev, Tamara Castellvi-Bel, Sergi Cavic, Milena Jankovic, Goran |
author_facet | Nikolic, Neda Radosavljevic, Davorin Gavrilovic, Dusica Nikolic, Vladimir Stanic, Nemanja Spasic, Jelena Cacev, Tamara Castellvi-Bel, Sergi Cavic, Milena Jankovic, Goran |
author_sort | Nikolic, Neda |
collection | PubMed |
description | Background and objectives: This study aimed to evaluate prognostic factors for post-recurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All patients underwent operative treatment of the primary tumor and adjuvant fluorouracil-based chemotherapy. Results: Over the three-year period (2008–2010), a cohort of 273 patients with stage III and high-risk stage II colorectal cancer had been screened. During follow up, 105 (38.5%) patients had disease recurrence. Survival rates 1-, 3- and 5-year after recurrence were 53.9, 18.2 and 6.5%, respectively, and the median post-recurrence survival time was 13 months. Survival analysis showed that age at diagnosis (p < 0.01), gender (p < 0.05), elevated postoperative Ca19-9 (p < 0.01), tumor histology (adenocarcinoma vs. mucinous vs. signet ring tumors, p < 0.01) and tumor stage (II vs. III, p < 0.05) had a significant influence on post-recurrence survival. Recurrence interval and metastatic site were not related to survival following recurrence. Multivariate analysis showed that older age (HR 2.43), mucinous tumors (HR 1.51) and tumors expressing Ca19-9 at baseline (HR 3.51) were independently associated with survival following recurrence. Conclusions: Baseline patient and tumor characteristics largely predicted patient outcomes after disease recurrence. Recurrence intervals in local and locally advanced colorectal cancer were not found to be prognostic factors for post-recurrence survival. Older age, male gender, stage III and mucinous histology were poor prognostic factors after the disease had recurred. Stage II patients had remarkable post-recurrence survival compared to stage III patients. |
format | Online Article Text |
id | pubmed-8538010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85380102021-10-24 Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients Nikolic, Neda Radosavljevic, Davorin Gavrilovic, Dusica Nikolic, Vladimir Stanic, Nemanja Spasic, Jelena Cacev, Tamara Castellvi-Bel, Sergi Cavic, Milena Jankovic, Goran Medicina (Kaunas) Article Background and objectives: This study aimed to evaluate prognostic factors for post-recurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All patients underwent operative treatment of the primary tumor and adjuvant fluorouracil-based chemotherapy. Results: Over the three-year period (2008–2010), a cohort of 273 patients with stage III and high-risk stage II colorectal cancer had been screened. During follow up, 105 (38.5%) patients had disease recurrence. Survival rates 1-, 3- and 5-year after recurrence were 53.9, 18.2 and 6.5%, respectively, and the median post-recurrence survival time was 13 months. Survival analysis showed that age at diagnosis (p < 0.01), gender (p < 0.05), elevated postoperative Ca19-9 (p < 0.01), tumor histology (adenocarcinoma vs. mucinous vs. signet ring tumors, p < 0.01) and tumor stage (II vs. III, p < 0.05) had a significant influence on post-recurrence survival. Recurrence interval and metastatic site were not related to survival following recurrence. Multivariate analysis showed that older age (HR 2.43), mucinous tumors (HR 1.51) and tumors expressing Ca19-9 at baseline (HR 3.51) were independently associated with survival following recurrence. Conclusions: Baseline patient and tumor characteristics largely predicted patient outcomes after disease recurrence. Recurrence intervals in local and locally advanced colorectal cancer were not found to be prognostic factors for post-recurrence survival. Older age, male gender, stage III and mucinous histology were poor prognostic factors after the disease had recurred. Stage II patients had remarkable post-recurrence survival compared to stage III patients. MDPI 2021-10-15 /pmc/articles/PMC8538010/ /pubmed/34684145 http://dx.doi.org/10.3390/medicina57101108 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nikolic, Neda Radosavljevic, Davorin Gavrilovic, Dusica Nikolic, Vladimir Stanic, Nemanja Spasic, Jelena Cacev, Tamara Castellvi-Bel, Sergi Cavic, Milena Jankovic, Goran Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients |
title | Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients |
title_full | Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients |
title_fullStr | Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients |
title_full_unstemmed | Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients |
title_short | Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients |
title_sort | prognostic factors for post-recurrence survival in stage ii and iii colorectal carcinoma patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538010/ https://www.ncbi.nlm.nih.gov/pubmed/34684145 http://dx.doi.org/10.3390/medicina57101108 |
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