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Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients

Background and objectives: This study aimed to evaluate prognostic factors for post-recurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All pa...

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Autores principales: Nikolic, Neda, Radosavljevic, Davorin, Gavrilovic, Dusica, Nikolic, Vladimir, Stanic, Nemanja, Spasic, Jelena, Cacev, Tamara, Castellvi-Bel, Sergi, Cavic, Milena, Jankovic, Goran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538010/
https://www.ncbi.nlm.nih.gov/pubmed/34684145
http://dx.doi.org/10.3390/medicina57101108
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author Nikolic, Neda
Radosavljevic, Davorin
Gavrilovic, Dusica
Nikolic, Vladimir
Stanic, Nemanja
Spasic, Jelena
Cacev, Tamara
Castellvi-Bel, Sergi
Cavic, Milena
Jankovic, Goran
author_facet Nikolic, Neda
Radosavljevic, Davorin
Gavrilovic, Dusica
Nikolic, Vladimir
Stanic, Nemanja
Spasic, Jelena
Cacev, Tamara
Castellvi-Bel, Sergi
Cavic, Milena
Jankovic, Goran
author_sort Nikolic, Neda
collection PubMed
description Background and objectives: This study aimed to evaluate prognostic factors for post-recurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All patients underwent operative treatment of the primary tumor and adjuvant fluorouracil-based chemotherapy. Results: Over the three-year period (2008–2010), a cohort of 273 patients with stage III and high-risk stage II colorectal cancer had been screened. During follow up, 105 (38.5%) patients had disease recurrence. Survival rates 1-, 3- and 5-year after recurrence were 53.9, 18.2 and 6.5%, respectively, and the median post-recurrence survival time was 13 months. Survival analysis showed that age at diagnosis (p < 0.01), gender (p < 0.05), elevated postoperative Ca19-9 (p < 0.01), tumor histology (adenocarcinoma vs. mucinous vs. signet ring tumors, p < 0.01) and tumor stage (II vs. III, p < 0.05) had a significant influence on post-recurrence survival. Recurrence interval and metastatic site were not related to survival following recurrence. Multivariate analysis showed that older age (HR 2.43), mucinous tumors (HR 1.51) and tumors expressing Ca19-9 at baseline (HR 3.51) were independently associated with survival following recurrence. Conclusions: Baseline patient and tumor characteristics largely predicted patient outcomes after disease recurrence. Recurrence intervals in local and locally advanced colorectal cancer were not found to be prognostic factors for post-recurrence survival. Older age, male gender, stage III and mucinous histology were poor prognostic factors after the disease had recurred. Stage II patients had remarkable post-recurrence survival compared to stage III patients.
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spelling pubmed-85380102021-10-24 Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients Nikolic, Neda Radosavljevic, Davorin Gavrilovic, Dusica Nikolic, Vladimir Stanic, Nemanja Spasic, Jelena Cacev, Tamara Castellvi-Bel, Sergi Cavic, Milena Jankovic, Goran Medicina (Kaunas) Article Background and objectives: This study aimed to evaluate prognostic factors for post-recurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All patients underwent operative treatment of the primary tumor and adjuvant fluorouracil-based chemotherapy. Results: Over the three-year period (2008–2010), a cohort of 273 patients with stage III and high-risk stage II colorectal cancer had been screened. During follow up, 105 (38.5%) patients had disease recurrence. Survival rates 1-, 3- and 5-year after recurrence were 53.9, 18.2 and 6.5%, respectively, and the median post-recurrence survival time was 13 months. Survival analysis showed that age at diagnosis (p < 0.01), gender (p < 0.05), elevated postoperative Ca19-9 (p < 0.01), tumor histology (adenocarcinoma vs. mucinous vs. signet ring tumors, p < 0.01) and tumor stage (II vs. III, p < 0.05) had a significant influence on post-recurrence survival. Recurrence interval and metastatic site were not related to survival following recurrence. Multivariate analysis showed that older age (HR 2.43), mucinous tumors (HR 1.51) and tumors expressing Ca19-9 at baseline (HR 3.51) were independently associated with survival following recurrence. Conclusions: Baseline patient and tumor characteristics largely predicted patient outcomes after disease recurrence. Recurrence intervals in local and locally advanced colorectal cancer were not found to be prognostic factors for post-recurrence survival. Older age, male gender, stage III and mucinous histology were poor prognostic factors after the disease had recurred. Stage II patients had remarkable post-recurrence survival compared to stage III patients. MDPI 2021-10-15 /pmc/articles/PMC8538010/ /pubmed/34684145 http://dx.doi.org/10.3390/medicina57101108 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nikolic, Neda
Radosavljevic, Davorin
Gavrilovic, Dusica
Nikolic, Vladimir
Stanic, Nemanja
Spasic, Jelena
Cacev, Tamara
Castellvi-Bel, Sergi
Cavic, Milena
Jankovic, Goran
Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients
title Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients
title_full Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients
title_fullStr Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients
title_full_unstemmed Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients
title_short Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients
title_sort prognostic factors for post-recurrence survival in stage ii and iii colorectal carcinoma patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538010/
https://www.ncbi.nlm.nih.gov/pubmed/34684145
http://dx.doi.org/10.3390/medicina57101108
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