Alveolar Regeneration in COVID-19 Patients: A Network Perspective

A viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regener...

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Autores principales: Gupta, Shishir K., Srivastava, Mugdha, Minocha, Rashmi, Akash, Aman, Dangwal, Seema, Dandekar, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538208/
https://www.ncbi.nlm.nih.gov/pubmed/34681944
http://dx.doi.org/10.3390/ijms222011279
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author Gupta, Shishir K.
Srivastava, Mugdha
Minocha, Rashmi
Akash, Aman
Dangwal, Seema
Dandekar, Thomas
author_facet Gupta, Shishir K.
Srivastava, Mugdha
Minocha, Rashmi
Akash, Aman
Dangwal, Seema
Dandekar, Thomas
author_sort Gupta, Shishir K.
collection PubMed
description A viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regeneration and fibrotic repair processes being the two protective host responses, prolonged injury may lead to excessive fibrosis, a pathological state that can result in lung collapse. In this review, we discuss regeneration and fibrosis processes in response to SARS-CoV-2 and provide our viewpoint on the triggering of alveolar regeneration in coronavirus disease 2019 (COVID-19) patients.
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spelling pubmed-85382082021-10-24 Alveolar Regeneration in COVID-19 Patients: A Network Perspective Gupta, Shishir K. Srivastava, Mugdha Minocha, Rashmi Akash, Aman Dangwal, Seema Dandekar, Thomas Int J Mol Sci Review A viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regeneration and fibrotic repair processes being the two protective host responses, prolonged injury may lead to excessive fibrosis, a pathological state that can result in lung collapse. In this review, we discuss regeneration and fibrosis processes in response to SARS-CoV-2 and provide our viewpoint on the triggering of alveolar regeneration in coronavirus disease 2019 (COVID-19) patients. MDPI 2021-10-19 /pmc/articles/PMC8538208/ /pubmed/34681944 http://dx.doi.org/10.3390/ijms222011279 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gupta, Shishir K.
Srivastava, Mugdha
Minocha, Rashmi
Akash, Aman
Dangwal, Seema
Dandekar, Thomas
Alveolar Regeneration in COVID-19 Patients: A Network Perspective
title Alveolar Regeneration in COVID-19 Patients: A Network Perspective
title_full Alveolar Regeneration in COVID-19 Patients: A Network Perspective
title_fullStr Alveolar Regeneration in COVID-19 Patients: A Network Perspective
title_full_unstemmed Alveolar Regeneration in COVID-19 Patients: A Network Perspective
title_short Alveolar Regeneration in COVID-19 Patients: A Network Perspective
title_sort alveolar regeneration in covid-19 patients: a network perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538208/
https://www.ncbi.nlm.nih.gov/pubmed/34681944
http://dx.doi.org/10.3390/ijms222011279
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