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SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism
Coronavirus disease 2019 (COVID-19) has so far infected hundreds of million individuals, with several million deaths worldwide. The lack of understanding of the disease pathophysiology and the host’s immune response has resulted in this rapid spread of the disease on a global scale. In this respect,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538244/ https://www.ncbi.nlm.nih.gov/pubmed/34677374 http://dx.doi.org/10.3390/metabo11100659 |
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author | Kaur, Gagandeep Ji, Xiangming Rahman, Irfan |
author_facet | Kaur, Gagandeep Ji, Xiangming Rahman, Irfan |
author_sort | Kaur, Gagandeep |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) has so far infected hundreds of million individuals, with several million deaths worldwide. The lack of understanding of the disease pathophysiology and the host’s immune response has resulted in this rapid spread of the disease on a global scale. In this respect, we employed UPLC-MS to compare the metabolites in the serum from COVID-19-positive patients and COVID-19-recovered subjects to determine the metabolic changes responsible for an infection. Our investigations revealed significant increase in the levels of serum phospholipids including sphingomyelins, phosphatidylcholines and arachidonic acid in the serum of COVID-19-positive patients as compared to COVID-19-recovered individuals. We further show increased levels of tryptophan and its metabolites in the serum of COVID-19-positive patients thus emphasizing the role of tryptophan metabolism in the disease pathogenesis of COVID-19. Future studies are required to determine the changes in the lipid and tryptophan metabolism at various stages of COVID-19 disease development, progression and recovery to better understand the host–pathogen interaction and the long-term effects of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection in humans. |
format | Online Article Text |
id | pubmed-8538244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85382442021-10-24 SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism Kaur, Gagandeep Ji, Xiangming Rahman, Irfan Metabolites Article Coronavirus disease 2019 (COVID-19) has so far infected hundreds of million individuals, with several million deaths worldwide. The lack of understanding of the disease pathophysiology and the host’s immune response has resulted in this rapid spread of the disease on a global scale. In this respect, we employed UPLC-MS to compare the metabolites in the serum from COVID-19-positive patients and COVID-19-recovered subjects to determine the metabolic changes responsible for an infection. Our investigations revealed significant increase in the levels of serum phospholipids including sphingomyelins, phosphatidylcholines and arachidonic acid in the serum of COVID-19-positive patients as compared to COVID-19-recovered individuals. We further show increased levels of tryptophan and its metabolites in the serum of COVID-19-positive patients thus emphasizing the role of tryptophan metabolism in the disease pathogenesis of COVID-19. Future studies are required to determine the changes in the lipid and tryptophan metabolism at various stages of COVID-19 disease development, progression and recovery to better understand the host–pathogen interaction and the long-term effects of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection in humans. MDPI 2021-09-28 /pmc/articles/PMC8538244/ /pubmed/34677374 http://dx.doi.org/10.3390/metabo11100659 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kaur, Gagandeep Ji, Xiangming Rahman, Irfan SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism |
title | SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism |
title_full | SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism |
title_fullStr | SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism |
title_full_unstemmed | SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism |
title_short | SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism |
title_sort | sars-cov2 infection alters tryptophan catabolism and phospholipid metabolism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538244/ https://www.ncbi.nlm.nih.gov/pubmed/34677374 http://dx.doi.org/10.3390/metabo11100659 |
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