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Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19
Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538263/ https://www.ncbi.nlm.nih.gov/pubmed/34696336 http://dx.doi.org/10.3390/v13101906 |
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author | Espino-y-Sosa, Salvador Martinez-Portilla, Raigam Jafet Torres-Torres, Johnatan Solis-Paredes, Juan Mario Estrada-Gutierrez, Guadalupe Hernandez-Pacheco, Jose Antonio Espejel-Nuñez, Aurora Mateu-Rogell, Paloma Juarez-Reyes, Angeles Lopez-Ceh, Francisco Eduardo Villafan-Bernal, Jose Rafael Rojas-Zepeda, Lourdes Guzman-Guzman, Iris Paola Poon, Liona C. |
author_facet | Espino-y-Sosa, Salvador Martinez-Portilla, Raigam Jafet Torres-Torres, Johnatan Solis-Paredes, Juan Mario Estrada-Gutierrez, Guadalupe Hernandez-Pacheco, Jose Antonio Espejel-Nuñez, Aurora Mateu-Rogell, Paloma Juarez-Reyes, Angeles Lopez-Ceh, Francisco Eduardo Villafan-Bernal, Jose Rafael Rojas-Zepeda, Lourdes Guzman-Guzman, Iris Paola Poon, Liona C. |
author_sort | Espino-y-Sosa, Salvador |
collection | PubMed |
description | Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman’s Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; p = 0.003), ICU admission (OR: 1.05; p = 0.007); intubation (OR: 1.09; p = 0.008); sepsis (OR: 1.04; p = 0.008); and death (OR: 1.04; p = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19. |
format | Online Article Text |
id | pubmed-8538263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85382632021-10-24 Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 Espino-y-Sosa, Salvador Martinez-Portilla, Raigam Jafet Torres-Torres, Johnatan Solis-Paredes, Juan Mario Estrada-Gutierrez, Guadalupe Hernandez-Pacheco, Jose Antonio Espejel-Nuñez, Aurora Mateu-Rogell, Paloma Juarez-Reyes, Angeles Lopez-Ceh, Francisco Eduardo Villafan-Bernal, Jose Rafael Rojas-Zepeda, Lourdes Guzman-Guzman, Iris Paola Poon, Liona C. Viruses Brief Report Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman’s Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; p = 0.003), ICU admission (OR: 1.05; p = 0.007); intubation (OR: 1.09; p = 0.008); sepsis (OR: 1.04; p = 0.008); and death (OR: 1.04; p = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19. MDPI 2021-09-23 /pmc/articles/PMC8538263/ /pubmed/34696336 http://dx.doi.org/10.3390/v13101906 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Espino-y-Sosa, Salvador Martinez-Portilla, Raigam Jafet Torres-Torres, Johnatan Solis-Paredes, Juan Mario Estrada-Gutierrez, Guadalupe Hernandez-Pacheco, Jose Antonio Espejel-Nuñez, Aurora Mateu-Rogell, Paloma Juarez-Reyes, Angeles Lopez-Ceh, Francisco Eduardo Villafan-Bernal, Jose Rafael Rojas-Zepeda, Lourdes Guzman-Guzman, Iris Paola Poon, Liona C. Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
title | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
title_full | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
title_fullStr | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
title_full_unstemmed | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
title_short | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
title_sort | novel ratio soluble fms-like tyrosine kinase-1/angiotensin-ii (sflt-1/ang-ii) in pregnant women is associated with critical illness in covid-19 |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538263/ https://www.ncbi.nlm.nih.gov/pubmed/34696336 http://dx.doi.org/10.3390/v13101906 |
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