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Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19

Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor...

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Autores principales: Espino-y-Sosa, Salvador, Martinez-Portilla, Raigam Jafet, Torres-Torres, Johnatan, Solis-Paredes, Juan Mario, Estrada-Gutierrez, Guadalupe, Hernandez-Pacheco, Jose Antonio, Espejel-Nuñez, Aurora, Mateu-Rogell, Paloma, Juarez-Reyes, Angeles, Lopez-Ceh, Francisco Eduardo, Villafan-Bernal, Jose Rafael, Rojas-Zepeda, Lourdes, Guzman-Guzman, Iris Paola, Poon, Liona C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538263/
https://www.ncbi.nlm.nih.gov/pubmed/34696336
http://dx.doi.org/10.3390/v13101906
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author Espino-y-Sosa, Salvador
Martinez-Portilla, Raigam Jafet
Torres-Torres, Johnatan
Solis-Paredes, Juan Mario
Estrada-Gutierrez, Guadalupe
Hernandez-Pacheco, Jose Antonio
Espejel-Nuñez, Aurora
Mateu-Rogell, Paloma
Juarez-Reyes, Angeles
Lopez-Ceh, Francisco Eduardo
Villafan-Bernal, Jose Rafael
Rojas-Zepeda, Lourdes
Guzman-Guzman, Iris Paola
Poon, Liona C.
author_facet Espino-y-Sosa, Salvador
Martinez-Portilla, Raigam Jafet
Torres-Torres, Johnatan
Solis-Paredes, Juan Mario
Estrada-Gutierrez, Guadalupe
Hernandez-Pacheco, Jose Antonio
Espejel-Nuñez, Aurora
Mateu-Rogell, Paloma
Juarez-Reyes, Angeles
Lopez-Ceh, Francisco Eduardo
Villafan-Bernal, Jose Rafael
Rojas-Zepeda, Lourdes
Guzman-Guzman, Iris Paola
Poon, Liona C.
author_sort Espino-y-Sosa, Salvador
collection PubMed
description Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman’s Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; p = 0.003), ICU admission (OR: 1.05; p = 0.007); intubation (OR: 1.09; p = 0.008); sepsis (OR: 1.04; p = 0.008); and death (OR: 1.04; p = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19.
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spelling pubmed-85382632021-10-24 Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 Espino-y-Sosa, Salvador Martinez-Portilla, Raigam Jafet Torres-Torres, Johnatan Solis-Paredes, Juan Mario Estrada-Gutierrez, Guadalupe Hernandez-Pacheco, Jose Antonio Espejel-Nuñez, Aurora Mateu-Rogell, Paloma Juarez-Reyes, Angeles Lopez-Ceh, Francisco Eduardo Villafan-Bernal, Jose Rafael Rojas-Zepeda, Lourdes Guzman-Guzman, Iris Paola Poon, Liona C. Viruses Brief Report Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman’s Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; p = 0.003), ICU admission (OR: 1.05; p = 0.007); intubation (OR: 1.09; p = 0.008); sepsis (OR: 1.04; p = 0.008); and death (OR: 1.04; p = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19. MDPI 2021-09-23 /pmc/articles/PMC8538263/ /pubmed/34696336 http://dx.doi.org/10.3390/v13101906 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Espino-y-Sosa, Salvador
Martinez-Portilla, Raigam Jafet
Torres-Torres, Johnatan
Solis-Paredes, Juan Mario
Estrada-Gutierrez, Guadalupe
Hernandez-Pacheco, Jose Antonio
Espejel-Nuñez, Aurora
Mateu-Rogell, Paloma
Juarez-Reyes, Angeles
Lopez-Ceh, Francisco Eduardo
Villafan-Bernal, Jose Rafael
Rojas-Zepeda, Lourdes
Guzman-Guzman, Iris Paola
Poon, Liona C.
Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19
title Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19
title_full Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19
title_fullStr Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19
title_full_unstemmed Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19
title_short Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19
title_sort novel ratio soluble fms-like tyrosine kinase-1/angiotensin-ii (sflt-1/ang-ii) in pregnant women is associated with critical illness in covid-19
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538263/
https://www.ncbi.nlm.nih.gov/pubmed/34696336
http://dx.doi.org/10.3390/v13101906
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