Cargando…
Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine)
A 43-year-old male, sport coach, presented him-self at the Emergency unit of a local hospital for epigastric pain, myalgia pain and severe headache. He claimed having used for some days a combination of GW1516 (cardarine), a peroxisome proliferator-activated receptor delta agonist (PPAR- δ) and MK28...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538264/ https://www.ncbi.nlm.nih.gov/pubmed/34678947 http://dx.doi.org/10.3390/toxics9100251 |
_version_ | 1784588463805300736 |
---|---|
author | Kintz, Pascal Gheddar, Laurie Paradis, Camille Chinellato, Mickael Ameline, Alice Raul, Jean-Sébastien Oliva-Labadie, Magali |
author_facet | Kintz, Pascal Gheddar, Laurie Paradis, Camille Chinellato, Mickael Ameline, Alice Raul, Jean-Sébastien Oliva-Labadie, Magali |
author_sort | Kintz, Pascal |
collection | PubMed |
description | A 43-year-old male, sport coach, presented him-self at the Emergency unit of a local hospital for epigastric pain, myalgia pain and severe headache. He claimed having used for some days a combination of GW1516 (cardarine), a peroxisome proliferator-activated receptor delta agonist (PPAR- δ) and MK2866 (ostarine), a selective androgen receptor modulator (SARM) to gain skeletal muscles. Cytolysis with marked increase of alanine aminotransferase or ALT (up to 922 UI/L) and aspartate aminotransferase or AST (up to 2558 UI/L) and massive rhabdomyolysis with elevated creatine phosphokinase or CPK (up to 86435 UI/L) were the main unusual biochemistry parameters. Using a specific liquid chromatography coupled to tandem mass spectrometry method, cardarine and ostarine tested positive in blood at 403 and 1 ng/mL, respectively. In urine, due to extensive metabolism, the parent GW1516 was not identified, while ostarine was at 88 ng/mL. Finally, both drugs were identified in hair (2 cm in length, brown in colour), at 146 and 1105 pg/mg for cardarine and ostarine, respectively. This clearly demonstrates repetitive abuse over the last 2 months. Asthenia was persistent for 2 weeks and 6 weeks after the admission, the subject fully recovered. |
format | Online Article Text |
id | pubmed-8538264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85382642021-10-24 Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine) Kintz, Pascal Gheddar, Laurie Paradis, Camille Chinellato, Mickael Ameline, Alice Raul, Jean-Sébastien Oliva-Labadie, Magali Toxics Article A 43-year-old male, sport coach, presented him-self at the Emergency unit of a local hospital for epigastric pain, myalgia pain and severe headache. He claimed having used for some days a combination of GW1516 (cardarine), a peroxisome proliferator-activated receptor delta agonist (PPAR- δ) and MK2866 (ostarine), a selective androgen receptor modulator (SARM) to gain skeletal muscles. Cytolysis with marked increase of alanine aminotransferase or ALT (up to 922 UI/L) and aspartate aminotransferase or AST (up to 2558 UI/L) and massive rhabdomyolysis with elevated creatine phosphokinase or CPK (up to 86435 UI/L) were the main unusual biochemistry parameters. Using a specific liquid chromatography coupled to tandem mass spectrometry method, cardarine and ostarine tested positive in blood at 403 and 1 ng/mL, respectively. In urine, due to extensive metabolism, the parent GW1516 was not identified, while ostarine was at 88 ng/mL. Finally, both drugs were identified in hair (2 cm in length, brown in colour), at 146 and 1105 pg/mg for cardarine and ostarine, respectively. This clearly demonstrates repetitive abuse over the last 2 months. Asthenia was persistent for 2 weeks and 6 weeks after the admission, the subject fully recovered. MDPI 2021-10-07 /pmc/articles/PMC8538264/ /pubmed/34678947 http://dx.doi.org/10.3390/toxics9100251 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kintz, Pascal Gheddar, Laurie Paradis, Camille Chinellato, Mickael Ameline, Alice Raul, Jean-Sébastien Oliva-Labadie, Magali Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine) |
title | Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine) |
title_full | Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine) |
title_fullStr | Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine) |
title_full_unstemmed | Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine) |
title_short | Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine) |
title_sort | peroxisome proliferator-activated receptor delta agonist (ppar- δ) and selective androgen receptor modulator (sarm) abuse: clinical, analytical and biological data in a case involving a poisonous combination of gw1516 (cardarine) and mk2866 (ostarine) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538264/ https://www.ncbi.nlm.nih.gov/pubmed/34678947 http://dx.doi.org/10.3390/toxics9100251 |
work_keys_str_mv | AT kintzpascal peroxisomeproliferatoractivatedreceptordeltaagonistppardandselectiveandrogenreceptormodulatorsarmabuseclinicalanalyticalandbiologicaldatainacaseinvolvingapoisonouscombinationofgw1516cardarineandmk2866ostarine AT gheddarlaurie peroxisomeproliferatoractivatedreceptordeltaagonistppardandselectiveandrogenreceptormodulatorsarmabuseclinicalanalyticalandbiologicaldatainacaseinvolvingapoisonouscombinationofgw1516cardarineandmk2866ostarine AT paradiscamille peroxisomeproliferatoractivatedreceptordeltaagonistppardandselectiveandrogenreceptormodulatorsarmabuseclinicalanalyticalandbiologicaldatainacaseinvolvingapoisonouscombinationofgw1516cardarineandmk2866ostarine AT chinellatomickael peroxisomeproliferatoractivatedreceptordeltaagonistppardandselectiveandrogenreceptormodulatorsarmabuseclinicalanalyticalandbiologicaldatainacaseinvolvingapoisonouscombinationofgw1516cardarineandmk2866ostarine AT amelinealice peroxisomeproliferatoractivatedreceptordeltaagonistppardandselectiveandrogenreceptormodulatorsarmabuseclinicalanalyticalandbiologicaldatainacaseinvolvingapoisonouscombinationofgw1516cardarineandmk2866ostarine AT rauljeansebastien peroxisomeproliferatoractivatedreceptordeltaagonistppardandselectiveandrogenreceptormodulatorsarmabuseclinicalanalyticalandbiologicaldatainacaseinvolvingapoisonouscombinationofgw1516cardarineandmk2866ostarine AT olivalabadiemagali peroxisomeproliferatoractivatedreceptordeltaagonistppardandselectiveandrogenreceptormodulatorsarmabuseclinicalanalyticalandbiologicaldatainacaseinvolvingapoisonouscombinationofgw1516cardarineandmk2866ostarine |