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Ustekinumab Dosing Individualization in Crohn’s Disease Guided by a Population Pharmacokinetic–Pharmacodynamic Model

Ustekinumab is a monoclonal antibody used in Crohn’s disease (CD). Dose optimization in case of non-response and the role of pharmacokinetic–pharmacodynamic (PK-PD) monitoring remain unresolved dilemmas in clinical practice. We aimed to develop a population PK-PD model for ustekinumab in CD and simu...

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Detalles Bibliográficos
Autores principales:	Aguiar Zdovc, Jurij, Hanžel, Jurij, Kurent, Tina, Sever, Nejc, Koželj, Matic, Smrekar, Nataša, Novak, Gregor, Štabuc, Borut, Dreesen, Erwin, Thomas, Debby, Vovk, Tomaž, Ostanek, Barbara, Drobne, David, Grabnar, Iztok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538292/ https://www.ncbi.nlm.nih.gov/pubmed/34683880 http://dx.doi.org/10.3390/pharmaceutics13101587

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