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Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles

Pulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 μm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glyco...

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Autores principales: Alhajj, Nasser, Naharudin, Idanawati, Colombo, Paolo, Quarta, Eride, Wong, Tin Wui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538302/
https://www.ncbi.nlm.nih.gov/pubmed/34683876
http://dx.doi.org/10.3390/pharmaceutics13101581
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author Alhajj, Nasser
Naharudin, Idanawati
Colombo, Paolo
Quarta, Eride
Wong, Tin Wui
author_facet Alhajj, Nasser
Naharudin, Idanawati
Colombo, Paolo
Quarta, Eride
Wong, Tin Wui
author_sort Alhajj, Nasser
collection PubMed
description Pulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 μm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glycol (PEG) microparticles with different sizes, morphologies and crystallinities were prepared by a spray drying method using varying PEG molecular weights and ethanol contents. The chitosan nanoparticles were similarly prepared. In vitro inhalation performance and peripheral lung deposition of chitosan nanoparticles were enhanced through co-blending with larger lactose-PEG microparticles with reduced specific surface area. These microparticles had reduced inter-microparticle interaction, thereby promoting microparticle–nanoparticle interaction and facilitating nanoparticles flow into peripheral lung.
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spelling pubmed-85383022021-10-24 Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles Alhajj, Nasser Naharudin, Idanawati Colombo, Paolo Quarta, Eride Wong, Tin Wui Pharmaceutics Article Pulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 μm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glycol (PEG) microparticles with different sizes, morphologies and crystallinities were prepared by a spray drying method using varying PEG molecular weights and ethanol contents. The chitosan nanoparticles were similarly prepared. In vitro inhalation performance and peripheral lung deposition of chitosan nanoparticles were enhanced through co-blending with larger lactose-PEG microparticles with reduced specific surface area. These microparticles had reduced inter-microparticle interaction, thereby promoting microparticle–nanoparticle interaction and facilitating nanoparticles flow into peripheral lung. MDPI 2021-09-29 /pmc/articles/PMC8538302/ /pubmed/34683876 http://dx.doi.org/10.3390/pharmaceutics13101581 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alhajj, Nasser
Naharudin, Idanawati
Colombo, Paolo
Quarta, Eride
Wong, Tin Wui
Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles
title Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles
title_full Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles
title_fullStr Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles
title_full_unstemmed Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles
title_short Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles
title_sort probing critical physical properties of lactose-polyethylene glycol microparticles in pulmonary delivery of chitosan nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538302/
https://www.ncbi.nlm.nih.gov/pubmed/34683876
http://dx.doi.org/10.3390/pharmaceutics13101581
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