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Chemical Constituents of the Leaves of Diospyros kaki (Persimmon)
Diospyros kaki (persimmon) leaves have long been utilized as traditional medicine for the treatment of ischemic stroke, angina, and hypertension and as a healthy beverage and cosmetic for anti-aging. This study aimed to isolate as many compounds as possible from an ethanol extract of the persimmon l...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538319/ https://www.ncbi.nlm.nih.gov/pubmed/34685842 http://dx.doi.org/10.3390/plants10102032 |
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author | Kwon, Jaeyoung Park, Jeong-Eun Lee, Jin-Su Lee, Jung-Hwan Hwang, Hoseong Jung, Sang-Hoon Kwon, Hak-Cheol Jang, Dae-Sik |
author_facet | Kwon, Jaeyoung Park, Jeong-Eun Lee, Jin-Su Lee, Jung-Hwan Hwang, Hoseong Jung, Sang-Hoon Kwon, Hak-Cheol Jang, Dae-Sik |
author_sort | Kwon, Jaeyoung |
collection | PubMed |
description | Diospyros kaki (persimmon) leaves have long been utilized as traditional medicine for the treatment of ischemic stroke, angina, and hypertension and as a healthy beverage and cosmetic for anti-aging. This study aimed to isolate as many compounds as possible from an ethanol extract of the persimmon leaves to identify the biologically active compounds. The antioxidative effect of the ethyl acetate layer from the ethanol extract of the persimmon leaves was demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and online high-performance liquid chromatography-2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (HPLC-ABTS) analysis. A new flavonoid, kaempferol-3-O-β-d-2″-coumaroylgalactoside (1), and a new natural compound, kaempferol-3-O-β-d-2″-feruloylglucoside (3) were isolated from the ethyl acetate layer, along with 25 previously known compounds, including fourteen flavonoids, one ionone, two coumarins, seven triterpenoids, and one acetophenone. Their structures were determined by the interpretation of spectrometric and spectroscopic data. All isolated compounds were rapidly evaluated using an online HPLC-ABTS assay, and of these, compounds 4–8, 11, 13, 15, and 16 clearly showed antioxidative effects. The amount of these compounds was 0.3–0.65% of the extract. |
format | Online Article Text |
id | pubmed-8538319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85383192021-10-24 Chemical Constituents of the Leaves of Diospyros kaki (Persimmon) Kwon, Jaeyoung Park, Jeong-Eun Lee, Jin-Su Lee, Jung-Hwan Hwang, Hoseong Jung, Sang-Hoon Kwon, Hak-Cheol Jang, Dae-Sik Plants (Basel) Article Diospyros kaki (persimmon) leaves have long been utilized as traditional medicine for the treatment of ischemic stroke, angina, and hypertension and as a healthy beverage and cosmetic for anti-aging. This study aimed to isolate as many compounds as possible from an ethanol extract of the persimmon leaves to identify the biologically active compounds. The antioxidative effect of the ethyl acetate layer from the ethanol extract of the persimmon leaves was demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and online high-performance liquid chromatography-2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (HPLC-ABTS) analysis. A new flavonoid, kaempferol-3-O-β-d-2″-coumaroylgalactoside (1), and a new natural compound, kaempferol-3-O-β-d-2″-feruloylglucoside (3) were isolated from the ethyl acetate layer, along with 25 previously known compounds, including fourteen flavonoids, one ionone, two coumarins, seven triterpenoids, and one acetophenone. Their structures were determined by the interpretation of spectrometric and spectroscopic data. All isolated compounds were rapidly evaluated using an online HPLC-ABTS assay, and of these, compounds 4–8, 11, 13, 15, and 16 clearly showed antioxidative effects. The amount of these compounds was 0.3–0.65% of the extract. MDPI 2021-09-28 /pmc/articles/PMC8538319/ /pubmed/34685842 http://dx.doi.org/10.3390/plants10102032 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kwon, Jaeyoung Park, Jeong-Eun Lee, Jin-Su Lee, Jung-Hwan Hwang, Hoseong Jung, Sang-Hoon Kwon, Hak-Cheol Jang, Dae-Sik Chemical Constituents of the Leaves of Diospyros kaki (Persimmon) |
title | Chemical Constituents of the Leaves of Diospyros kaki (Persimmon) |
title_full | Chemical Constituents of the Leaves of Diospyros kaki (Persimmon) |
title_fullStr | Chemical Constituents of the Leaves of Diospyros kaki (Persimmon) |
title_full_unstemmed | Chemical Constituents of the Leaves of Diospyros kaki (Persimmon) |
title_short | Chemical Constituents of the Leaves of Diospyros kaki (Persimmon) |
title_sort | chemical constituents of the leaves of diospyros kaki (persimmon) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538319/ https://www.ncbi.nlm.nih.gov/pubmed/34685842 http://dx.doi.org/10.3390/plants10102032 |
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