Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5(−/−) Mice

Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachidonic acid 15-lipoxygenating Alox5 mutant instead of the 5-lipoxygenating wildtype enzyme. These mice were leukotriene d...

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Detalles Bibliográficos
Autores principales: Marbach-Breitrück, Eugenia, Rohwer, Nadine, Infante-Duarte, Carmen, Romero-Suarez, Silvina, Labuz, Dominika, Machelska, Halina, Kutzner, Laura, Schebb, Nils Helge, Rothe, Michael, Reddanna, Pallu, Weylandt, Karsten H., Wieler, Lothar H., Heydeck, Dagmar, Kuhn, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538363/
https://www.ncbi.nlm.nih.gov/pubmed/34677413
http://dx.doi.org/10.3390/metabo11100698

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