IAF, QGF, and QDF Peptides Exhibit Cholesterol-Lowering Activity through a Statin-like HMG-CoA Reductase Regulation Mechanism: In Silico and In Vitro Approach

In this study, in silico approaches are employed to investigate the binding mechanism of peptides derived from cowpea β-vignin and HMG-CoA reductase. With the obtained information, we designed synthetic peptides to evaluate their in vitro enzyme inhibitory activity. In vitro, the total protein extra...

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Detalles Bibliográficos
Autores principales: Silva, Mariana, Philadelpho, Biane, Santos, Johnnie, Souza, Victória, Souza, Caio, Santiago, Victória, Silva, Jaff, Souza, Carolina, Azeredo, Francine, Castilho, Marcelo, Cilli, Eduardo, Ferreira, Ederlan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538380/
https://www.ncbi.nlm.nih.gov/pubmed/34681729
http://dx.doi.org/10.3390/ijms222011067

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