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Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study

Background: Gestational diabetes can alter the trajectory of fetal development, but there are few studies on the effects of abnormal lipid metabolism on physical development of infants. We aimed to explore the prevalence of maternal dyslipidemia, its influencing factors and effects on the physical d...

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Autores principales: Li, Chenyang, Li, Xuening, Wu, Dan, Chen, Qi, Xiao, Zhe, Wen, Deliang, Zhai, Lingling, Jia, Lihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538455/
https://www.ncbi.nlm.nih.gov/pubmed/34684402
http://dx.doi.org/10.3390/nu13103398
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author Li, Chenyang
Li, Xuening
Wu, Dan
Chen, Qi
Xiao, Zhe
Wen, Deliang
Zhai, Lingling
Jia, Lihong
author_facet Li, Chenyang
Li, Xuening
Wu, Dan
Chen, Qi
Xiao, Zhe
Wen, Deliang
Zhai, Lingling
Jia, Lihong
author_sort Li, Chenyang
collection PubMed
description Background: Gestational diabetes can alter the trajectory of fetal development, but there are few studies on the effects of abnormal lipid metabolism on physical development of infants. We aimed to explore the prevalence of maternal dyslipidemia, its influencing factors and effects on the physical development of fetuses and infants, as well as the role of leptin in this process. Methods: Questionnaire surveys and main outcome measures were administered among 338 pairs of pregnant women and newborns. Results: The detection rate of maternal dyslipidemia was 31.5%. The median levels of TG (triglyceride) and TG/HDL (high-density lipoprotein) ratio were higher in large-for-gestational-age (LGA) newborns. Birth weight was positively related to infants’ height and weight at six months and one year old (p < 0.05). Leptin was positively related to TG levels of pregnant women and newborns’ birth weight (p < 0.05). Logistic regression analysis showed that having greater than or equal to four meals a day (OR = 6.552, 95%CI = 1.014–42.338) and liking to eat lightly flavored food during pregnancy (OR = 1.887, 95%CI = 1.048–3.395) were independent risk factors of maternal dyslipidemia. Conclusions: The prevalence of dyslipidemia was relatively high in pregnant women and was affected by dietary behaviors. Abnormal lipid levels during pregnancy could affect weight and length at birth, which might be associated with increasing leptin levels in cord blood, and then the weight of infants would be influenced by birth weight.
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spelling pubmed-85384552021-10-24 Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study Li, Chenyang Li, Xuening Wu, Dan Chen, Qi Xiao, Zhe Wen, Deliang Zhai, Lingling Jia, Lihong Nutrients Article Background: Gestational diabetes can alter the trajectory of fetal development, but there are few studies on the effects of abnormal lipid metabolism on physical development of infants. We aimed to explore the prevalence of maternal dyslipidemia, its influencing factors and effects on the physical development of fetuses and infants, as well as the role of leptin in this process. Methods: Questionnaire surveys and main outcome measures were administered among 338 pairs of pregnant women and newborns. Results: The detection rate of maternal dyslipidemia was 31.5%. The median levels of TG (triglyceride) and TG/HDL (high-density lipoprotein) ratio were higher in large-for-gestational-age (LGA) newborns. Birth weight was positively related to infants’ height and weight at six months and one year old (p < 0.05). Leptin was positively related to TG levels of pregnant women and newborns’ birth weight (p < 0.05). Logistic regression analysis showed that having greater than or equal to four meals a day (OR = 6.552, 95%CI = 1.014–42.338) and liking to eat lightly flavored food during pregnancy (OR = 1.887, 95%CI = 1.048–3.395) were independent risk factors of maternal dyslipidemia. Conclusions: The prevalence of dyslipidemia was relatively high in pregnant women and was affected by dietary behaviors. Abnormal lipid levels during pregnancy could affect weight and length at birth, which might be associated with increasing leptin levels in cord blood, and then the weight of infants would be influenced by birth weight. MDPI 2021-09-27 /pmc/articles/PMC8538455/ /pubmed/34684402 http://dx.doi.org/10.3390/nu13103398 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Chenyang
Li, Xuening
Wu, Dan
Chen, Qi
Xiao, Zhe
Wen, Deliang
Zhai, Lingling
Jia, Lihong
Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study
title Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study
title_full Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study
title_fullStr Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study
title_full_unstemmed Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study
title_short Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study
title_sort influence of dietary behaviors on dyslipidemia in pregnant women and its effects on physical development of fetuses and infants: a bidirectional cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538455/
https://www.ncbi.nlm.nih.gov/pubmed/34684402
http://dx.doi.org/10.3390/nu13103398
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