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PPAR-Gamma Activation May Inhibit the In Vivo Degeneration of Bioprosthetic Aortic and Aortic Valve Grafts under Diabetic Conditions

Background: We aimed to examine the anti-calcification and anti-inflammatory effects of pioglitazone as a PPAR-gamma agonist on bioprosthetic-valve-bearing aortic grafts in a rat model of diabetes mellitus (DM). Methods: DM was induced in male Wistar rats by high-fat diet with an intraperitoneal str...

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Detalles Bibliográficos
Autores principales:	Katahira, Shintaro, Sugimura, Yukiharu, Grupp, Sophia, Doepp, Robin, Selig, Jessica Isabel, Barth, Mareike, Lichtenberg, Artur, Akhyari, Payam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538504/ https://www.ncbi.nlm.nih.gov/pubmed/34681744 http://dx.doi.org/10.3390/ijms222011081

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