Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacologic...

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Autores principales: Hikmawanti, Ni Putu Ermi, Ramadon, Delly, Jantan, Ibrahim, Mun’im, Abdul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538609/
https://www.ncbi.nlm.nih.gov/pubmed/34685899
http://dx.doi.org/10.3390/plants10102091
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author Hikmawanti, Ni Putu Ermi
Ramadon, Delly
Jantan, Ibrahim
Mun’im, Abdul
author_facet Hikmawanti, Ni Putu Ermi
Ramadon, Delly
Jantan, Ibrahim
Mun’im, Abdul
author_sort Hikmawanti, Ni Putu Ermi
collection PubMed
description Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites-based nutraceuticals are discussed.
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spelling pubmed-85386092021-10-24 Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development Hikmawanti, Ni Putu Ermi Ramadon, Delly Jantan, Ibrahim Mun’im, Abdul Plants (Basel) Review Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites-based nutraceuticals are discussed. MDPI 2021-10-01 /pmc/articles/PMC8538609/ /pubmed/34685899 http://dx.doi.org/10.3390/plants10102091 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hikmawanti, Ni Putu Ermi
Ramadon, Delly
Jantan, Ibrahim
Mun’im, Abdul
Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development
title Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development
title_full Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development
title_fullStr Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development
title_full_unstemmed Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development
title_short Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development
title_sort natural deep eutectic solvents (nades): phytochemical extraction performance enhancer for pharmaceutical and nutraceutical product development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538609/
https://www.ncbi.nlm.nih.gov/pubmed/34685899
http://dx.doi.org/10.3390/plants10102091
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