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Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds
For years, fungi have served as repositories of bioactive secondary metabolites that form the backbone of many existing drugs. With the global rise in infections associated with antimicrobial resistance, in addition to the growing burden of non-communicable disease, such as cancer, diabetes and card...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538612/ https://www.ncbi.nlm.nih.gov/pubmed/34682208 http://dx.doi.org/10.3390/jof7100786 |
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author | Gakuubi, Martin Muthee Munusamy, Madhaiyan Liang, Zhao-Xun Ng, Siew Bee |
author_facet | Gakuubi, Martin Muthee Munusamy, Madhaiyan Liang, Zhao-Xun Ng, Siew Bee |
author_sort | Gakuubi, Martin Muthee |
collection | PubMed |
description | For years, fungi have served as repositories of bioactive secondary metabolites that form the backbone of many existing drugs. With the global rise in infections associated with antimicrobial resistance, in addition to the growing burden of non-communicable disease, such as cancer, diabetes and cardiovascular ailments, the demand for new drugs that can provide an improved therapeutic outcome has become the utmost priority. The exploration of microbes from understudied and specialized niches is one of the promising ways of discovering promising lead molecules for drug discovery. In recent years, a special class of plant-associated fungi, namely, fungal endophytes, have emerged as an important source of bioactive compounds with unique chemistry and interesting biological activities. The present review focuses on endophytic fungi and their classification, rationale for selection and prioritization of host plants for fungal isolation and examples of strategies that have been adopted to induce the activation of cryptic biosynthetic gene clusters to enhance the biosynthetic potential of fungal endophytes. |
format | Online Article Text |
id | pubmed-8538612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85386122021-10-24 Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds Gakuubi, Martin Muthee Munusamy, Madhaiyan Liang, Zhao-Xun Ng, Siew Bee J Fungi (Basel) Review For years, fungi have served as repositories of bioactive secondary metabolites that form the backbone of many existing drugs. With the global rise in infections associated with antimicrobial resistance, in addition to the growing burden of non-communicable disease, such as cancer, diabetes and cardiovascular ailments, the demand for new drugs that can provide an improved therapeutic outcome has become the utmost priority. The exploration of microbes from understudied and specialized niches is one of the promising ways of discovering promising lead molecules for drug discovery. In recent years, a special class of plant-associated fungi, namely, fungal endophytes, have emerged as an important source of bioactive compounds with unique chemistry and interesting biological activities. The present review focuses on endophytic fungi and their classification, rationale for selection and prioritization of host plants for fungal isolation and examples of strategies that have been adopted to induce the activation of cryptic biosynthetic gene clusters to enhance the biosynthetic potential of fungal endophytes. MDPI 2021-09-22 /pmc/articles/PMC8538612/ /pubmed/34682208 http://dx.doi.org/10.3390/jof7100786 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gakuubi, Martin Muthee Munusamy, Madhaiyan Liang, Zhao-Xun Ng, Siew Bee Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds |
title | Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds |
title_full | Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds |
title_fullStr | Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds |
title_full_unstemmed | Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds |
title_short | Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds |
title_sort | fungal endophytes: a promising frontier for discovery of novel bioactive compounds |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538612/ https://www.ncbi.nlm.nih.gov/pubmed/34682208 http://dx.doi.org/10.3390/jof7100786 |
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