Cargando…
The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs
Stimuli-sensitive nanocarriers have recently been developed as a powerful tool in biomedical applications such as drug delivery, detection, and gene transfer techniques. Among the external triggers investigated, low intensity magnetic fields represent a non-invasive way to remotely control the relea...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538647/ https://www.ncbi.nlm.nih.gov/pubmed/34684003 http://dx.doi.org/10.3390/pharmaceutics13101712 |
_version_ | 1784588556577013760 |
---|---|
author | Trilli, Jordan Caramazza, Laura Paolicelli, Patrizia Casadei, Maria Antonietta Liberti, Micaela Apollonio, Francesca Petralito, Stefania |
author_facet | Trilli, Jordan Caramazza, Laura Paolicelli, Patrizia Casadei, Maria Antonietta Liberti, Micaela Apollonio, Francesca Petralito, Stefania |
author_sort | Trilli, Jordan |
collection | PubMed |
description | Stimuli-sensitive nanocarriers have recently been developed as a powerful tool in biomedical applications such as drug delivery, detection, and gene transfer techniques. Among the external triggers investigated, low intensity magnetic fields represent a non-invasive way to remotely control the release of compounds from a magneto-sensitive carrier. Magnetoliposomes (MLs), i.e., liposomes entrapping magnetic nanoparticles (MNPs), are studied due to their capacity to transport hydrophobic and hydrophilic agents, their easy production, and due to the ability of MNPs to respond to a magnetic actuation determining the triggered release of the encapsulated compounds. Here we investigated the design and optimization of the MLs to obtain an efficient on-demand release of the transported compounds, due to the magneto-mechanical actuation induced by applying low-intensity pulsed electromagnetic fields (PEMFs). In particular we studied the effect of the bilayer packing on the ability of MLs, with oleic acid-coated MNPs encapsulated in the bilayer, to respond to PEMFs application. Three kinds of MLs are produced with an increasing rigidity of the bilayer, defined as Liquid Disorder, Liquid Order, and Gel MLs and the delivery of a hydrophilic dye (as a model drug) is investigated. Results demonstrate the efficacy of the magnetic trigger on high-ordered bilayers, which are unable to dampen the perturbation produced by MNPs motion. |
format | Online Article Text |
id | pubmed-8538647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85386472021-10-24 The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs Trilli, Jordan Caramazza, Laura Paolicelli, Patrizia Casadei, Maria Antonietta Liberti, Micaela Apollonio, Francesca Petralito, Stefania Pharmaceutics Article Stimuli-sensitive nanocarriers have recently been developed as a powerful tool in biomedical applications such as drug delivery, detection, and gene transfer techniques. Among the external triggers investigated, low intensity magnetic fields represent a non-invasive way to remotely control the release of compounds from a magneto-sensitive carrier. Magnetoliposomes (MLs), i.e., liposomes entrapping magnetic nanoparticles (MNPs), are studied due to their capacity to transport hydrophobic and hydrophilic agents, their easy production, and due to the ability of MNPs to respond to a magnetic actuation determining the triggered release of the encapsulated compounds. Here we investigated the design and optimization of the MLs to obtain an efficient on-demand release of the transported compounds, due to the magneto-mechanical actuation induced by applying low-intensity pulsed electromagnetic fields (PEMFs). In particular we studied the effect of the bilayer packing on the ability of MLs, with oleic acid-coated MNPs encapsulated in the bilayer, to respond to PEMFs application. Three kinds of MLs are produced with an increasing rigidity of the bilayer, defined as Liquid Disorder, Liquid Order, and Gel MLs and the delivery of a hydrophilic dye (as a model drug) is investigated. Results demonstrate the efficacy of the magnetic trigger on high-ordered bilayers, which are unable to dampen the perturbation produced by MNPs motion. MDPI 2021-10-16 /pmc/articles/PMC8538647/ /pubmed/34684003 http://dx.doi.org/10.3390/pharmaceutics13101712 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Trilli, Jordan Caramazza, Laura Paolicelli, Patrizia Casadei, Maria Antonietta Liberti, Micaela Apollonio, Francesca Petralito, Stefania The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs |
title | The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs |
title_full | The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs |
title_fullStr | The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs |
title_full_unstemmed | The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs |
title_short | The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs |
title_sort | impact of bilayer rigidity on the release from magnetoliposomes vesicles controlled by pemfs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538647/ https://www.ncbi.nlm.nih.gov/pubmed/34684003 http://dx.doi.org/10.3390/pharmaceutics13101712 |
work_keys_str_mv | AT trillijordan theimpactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT caramazzalaura theimpactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT paolicellipatrizia theimpactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT casadeimariaantonietta theimpactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT libertimicaela theimpactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT apolloniofrancesca theimpactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT petralitostefania theimpactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT trillijordan impactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT caramazzalaura impactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT paolicellipatrizia impactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT casadeimariaantonietta impactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT libertimicaela impactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT apolloniofrancesca impactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs AT petralitostefania impactofbilayerrigidityonthereleasefrommagnetoliposomesvesiclescontrolledbypemfs |