Cargando…

The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability

The culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kulesza, Jolanta, Pawłowska, Monika, Augustin, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538688/ https://www.ncbi.nlm.nih.gov/pubmed/34684841 http://dx.doi.org/10.3390/molecules26206262

Ejemplares similares

c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells
por: Pawłowska, Monika, et al.
Publicado: (2022)

Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures
por: Kulesza, Jolanta, et al.
Publicado: (2023)

Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
por: Mieszkowska, Anna, et al.
Publicado: (2021)

pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
por: Pilch, Joanna, et al.
Publicado: (2023)

Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
por: Pilch, Joanna, et al.
Publicado: (2022)

Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
por: Pilch, Joanna, et al.
Publicado: (2021)

Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis
por: Kosno, Michał, et al.
Publicado: (2022)

The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies
por: Laskowski, Tomasz, et al.
Publicado: (2023)

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions()
por: Potęga, Agnieszka, et al.
Publicado: (2021)

In Vitro Enzyme Kinetics and NMR-Based Product Elucidation for Glutathione S-Conjugation of the Anticancer Unsymmetrical Bisacridine C-2028 in Liver Microsomes and Cytosol: Major Role of Glutathione S-Transferase M1-1 Isoenzyme
por: Potęga, Agnieszka, et al.
Publicado: (2023)

Direct Synthesis of Unsymmetrical Dithioacetals
por: Bognar, Sabine, et al.
Publicado: (2021)

Direct Dehydrogenative Access to Unsymmetrical Phenones
por: Yu, Congjun, et al.
Publicado: (2022)

Neutral Unsymmetrical Coordinated Cyclophane Polymerization Catalysts
por: Schiebel, Eva, et al.
Publicado: (2021)

Influence of reduced concentration of L-glutamine on growth and viability of cells in monolayer, in spheroids, and in experimental tumours.
por: Tannock, I. F., et al.
Publicado: (1986)

Generation and Characterization of the C(3)O(2) (−) Anion with an Unexpected Unsymmetrical Structure
por: Wang, Lina, et al.
Publicado: (2021)

High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures
por: Sirenko, Oksana, et al.
Publicado: (2015)

Synthesis and Characterization of Unsymmetrical Double-Decker Siloxane (Basket Cage)
por: Kunthom, Rungthip, et al.
Publicado: (2019)

Symmetrical and unsymmetrical α,ω-nucleobase amide-conjugated systems
por: Boncel, Sławomir, et al.
Publicado: (2010)

Variation of pO2 in the growth medium of spheroids: interaction with glucose to influence spheroid growth and necrosis.
por: Tannock, I. F., et al.
Publicado: (1986)

Convenient Synthesis of Functionalized Unsymmetrical Vinyl Disulfides and Their Inverse Electron-Demand Hetero-Diels-Alder Reaction †
por: Jędrzejewski, Bartosz, et al.
Publicado: (2021)

Sterically Demanding Unsymmetrical Diaryl-λ(3)-iodanes for Electrophilic Pentafluorophenylation and an Approach to α-Pentafluorophenyl Carbonyl Compounds with an All-Carbon Stereocenter
por: Matsuzaki, Kohei, et al.
Publicado: (2014)

3D melanoma spheroid model for the development of positronium biomarkers
por: Karimi, Hanieh, et al.
Publicado: (2023)

1-(Triethoxysilyl)buta-1,3-dienes—New Building Blocks for Stereoselective Synthesis of Unsymmetrical (E,E)-1,4-Disubstituted 1,3-dienes
por: Szudkowska-Frątczak, Justyna, et al.
Publicado: (2015)

Luminescence and Electrochemical Activity of New Unsymmetrical 3-Imino-1,8-naphthalimide Derivatives
por: Kotowicz, Sonia, et al.
Publicado: (2021)

Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres
por: Ivanov, Delyan P., et al.
Publicado: (2014)

Mechanochemical halogenation of unsymmetrically substituted azobenzenes
por: Barišić, Dajana, et al.
Publicado: (2022)

CRISPR screens in cancer spheroids identify 3D growth specific vulnerabilities
por: Han, Kyuho, et al.
Publicado: (2020)

Antimicrobial studies of unsymmetrical bis-1,2,3-triazoles
por: Banday, Abid H, et al.
Publicado: (2012)

The Effects of Morinda citrifolia (Noni) on the Cellular Viability and Osteogenesis of Stem Cell Spheroids
por: Min, Sae Kyung, et al.
Publicado: (2020)

St. Thomas Modified Cardioplegia Effects on Myoblasts’ Viability and Morphology
por: Nowicki, Rafał, et al.
Publicado: (2022)

Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models
por: Hundsberger, Harald, et al.
Publicado: (2021)

Development of Spheroid-FPOP: An In-Cell Protein Footprinting Method for 3D Tumor Spheroids
por: Shortt, Raquel L., et al.
Publicado: (2023)

Effects of α-Mangostin on Viability, Growth and Cohesion of Multicellular Spheroids Derived from Human Breast Cancer Cell Lines
por: Scolamiero, Giuseppe, et al.
Publicado: (2018)

Monocyte Infiltration and Differentiation in 3D Multicellular Spheroid Cancer Models
por: Madsen, Natasha Helleberg, et al.
Publicado: (2021)

Influence of Clear(T) and Clear(T2) Agitation Conditions in the Fluorescence Imaging of 3D Spheroids
por: Silva, Daniel N., et al.
Publicado: (2020)

Multifrontal parallel distributed symmetric and unsymmetric solvers
por: Amestoy, P R, et al.
Publicado: (1998)

Polysulfurating reagent design for unsymmetrical polysulfide construction
por: Xiao, Xiao, et al.
Publicado: (2018)

A push–pull unsymmetrical subphthalocyanine dimer
por: Zango, Germán, et al.
Publicado: (2015)

Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides
por: Sudarikov, Denis V., et al.
Publicado: (2022)

Evaluation of the maintenance of stemness, viability, and differentiation potential of gingiva-derived stem-cell spheroids
por: Lee, Sung-Il, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8e8de5873eq9seoc6mhvokpb38