Cargando…

Orientin Improves Substrate Utilization and the Expression of Major Genes Involved in Insulin Signaling and Energy Regulation in Cultured Insulin-Resistant Liver Cells

Our group has progressively reported on the impact of bioactive compounds found in rooibos (Aspalathus linearis) and their capacity to modulate glucose homeostasis to improve metabolic function in experimental models of type 2 diabetes. In the current study, we investigated how the dietary flavone,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mazibuko-Mbeje, Sithandiwe E., Mthembu, Sinenhlanhla X. H., Tshiitamune, Andani, Muvhulawa, Ndivhuwo, Mthiyane, Fikile T., Ziqubu, Khanyisani, Muller, Christo J. F., Dludla, Phiwayinkosi V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538794/ https://www.ncbi.nlm.nih.gov/pubmed/34684734 http://dx.doi.org/10.3390/molecules26206154

Ejemplares similares

A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets
por: Mthiyane, Fikile T., et al.
Publicado: (2022)

Corrigendum: A review on the antidiabetic properties of Moringa oleifera extracts: Focusing on oxidative stress and inflammation as main therapeutic targets
por: Mthiyane, Fikile T., et al.
Publicado: (2023)

Rooibos Flavonoids, Aspalathin, Isoorientin, and Orientin Ameliorate Antimycin A-Induced Mitochondrial Dysfunction by Improving Mitochondrial Bioenergetics in Cultured Skeletal Muscle Cells
por: Mthembu, Sinenhlanhla X. H., et al.
Publicado: (2021)

An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
por: Ziqubu, Khanyisani, et al.
Publicado: (2023)

Impact of Isoorientin on Metabolic Activity and Lipid Accumulation in Differentiated Adipocytes
por: Ziqubu, Khanyisani, et al.
Publicado: (2020)

The Potential Role of Polyphenols in Modulating Mitochondrial Bioenergetics within the Skeletal Muscle: A Systematic Review of Preclinical Models
por: Mthembu, Sinenhlanhla X. H., et al.
Publicado: (2021)

Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration
por: Mazibuko-Mbeje, Sithandiwe E., et al.
Publicado: (2019)

Anti-Obesity Effects of Metformin: A Scoping Review Evaluating the Feasibility of Brown Adipose Tissue as a Therapeutic Target
por: Ziqubu, Khanyisani, et al.
Publicado: (2023)

Detrimental Effects of Lipid Peroxidation in Type 2 Diabetes: Exploring the Neutralizing Influence of Antioxidants
por: Shabalala, Samukelisiwe C., et al.
Publicado: (2022)

Isoorientin ameliorates lipid accumulation by regulating fat browning in palmitate-exposed 3T3-L1 adipocytes
por: Mazibuko-Mbeje, Sithandiwe E., et al.
Publicado: (2020)

Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
por: Dludla, Phiwayinkosi V, et al.
Publicado: (2023)

Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
por: Nyawo, Thembeka A., et al.
Publicado: (2021)

Drug-Induced Liver Injury: Clinical Evidence of N-Acetyl Cysteine Protective Effects
por: Ntamo, Yonela, et al.
Publicado: (2021)

Dietary Supplements Potentially Target Plasma Glutathione Levels to Improve Cardiometabolic Health in Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2023)

Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways
por: Mazibuko-Mbeje, Sithandiwe E., et al.
Publicado: (2019)

A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B-type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure
por: Nyawo, Thembeka A., et al.
Publicado: (2021)

Pathological Role of Oxidative Stress in Aflatoxin-Induced Toxicity in Different Experimental Models and Protective Effect of Phytochemicals: A Review
por: Jobe, Martha Cebile, et al.
Publicado: (2023)

N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

Vitamin C intake potentially lowers total cholesterol to improve endothelial function in diabetic patients at increased risk of cardiovascular disease: A systematic review of randomized controlled trials
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2022)

Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2023)

Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2023)

Natural killer cell levels in adults living with type 2 diabetes: a systematic review and meta-analysis of clinical studies
por: Mxinwa, Vuyolwethu, et al.
Publicado: (2020)

Dietary supplementation of low levels of unprocessed Mucuna pruriens utilis seed meal induces mild antinutritional entero-physio-metabolic perturbations without compromising performance and meat quality in finisher broilers
por: Zungu, Pretty Ntombizethu, et al.
Publicado: (2023)

Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2018)

N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q(9/10) levels
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2019)

A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy
por: Nyambuya, Tawanda M., et al.
Publicado: (2020)

Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

Coenzyme Q(10) Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

The Combination Effect of Aspalathin and Phenylpyruvic Acid-2-O-β-d-glucoside from Rooibos against Hyperglycemia-Induced Cardiac Damage: An In Vitro Study
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

Obesity-induced inflammation and insulin resistance: A mini-review on T-cells
por: Nyambuya, Tawanda Maurice, et al.
Publicado: (2019)

A Review on Medicinal Properties of Orientin
por: Lam, Kit Ying, et al.
Publicado: (2016)

Ocimum flavone Orientin as a countermeasure for thrombocytopenia
por: Yadav, Marshleen, et al.
Publicado: (2018)

Iso-Mukaadial Acetate from Warburgia salutaris Enhances Glucose Uptake in the L6 Rat Myoblast Cell Line
por: Msomi, Nontokozo Z., et al.
Publicado: (2019)

Therapeutic Effects of Curcumin Derivatives against Obesity and Associated Metabolic Complications: A Review of In Vitro and In Vivo Studies
por: Moetlediwa, Marakiya T., et al.
Publicado: (2023)

Attenuation of Oxidative Stress of Erythrocytes by Plant-Derived Flavonoids, Orientin and Luteolin
por: An, Fang, et al.
Publicado: (2016)

Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2017)

Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A
por: Wang, Li, et al.
Publicado: (2021)

Orientin Enhances Colistin-Mediated Bacterial Lethality through Oxidative Stress Involvement
por: Khumbulani, Madonsela, et al.
Publicado: (2022)

Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance
por: Nasca, Carla, et al.
Publicado: (2020)

The Transcription Profile Unveils the Cardio-Protective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model
por: Johnson, Rabia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_luh22q1qllb6on86k3730kd93r