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The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience
This study aims to estimate the prevalence rates of β-thalassemia and Sickle cell disorders in the adult population screened (n = 275,819) as part of the Kuwaiti National Premarital Screening Program. All the individuals who applied for a marriage license during the years 2009 and 2020 were covered...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538810/ https://www.ncbi.nlm.nih.gov/pubmed/34683121 http://dx.doi.org/10.3390/jpm11100980 |
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author | Rouh AlDeen, Najat Osman, Asmaa A Alhabashi, Monira J Al Khaldi, Rasha Alawadi, Hassan Alromh, Maha K Alyafai, Eiman G Akbulut-Jeradi, Nagihan |
author_facet | Rouh AlDeen, Najat Osman, Asmaa A Alhabashi, Monira J Al Khaldi, Rasha Alawadi, Hassan Alromh, Maha K Alyafai, Eiman G Akbulut-Jeradi, Nagihan |
author_sort | Rouh AlDeen, Najat |
collection | PubMed |
description | This study aims to estimate the prevalence rates of β-thalassemia and Sickle cell disorders in the adult population screened (n = 275,819) as part of the Kuwaiti National Premarital Screening Program. All the individuals who applied for a marriage license during the years 2009 and 2020 were covered by the program. A network of four reception centers in the Ministry of Health facilities and one Premarital Diagnostic Laboratory (PDL) in Maternity Hospital were involved in performing all investigations for hemoglobinopathies. The total number of individuals identified with β-thal trait was 5861 (2.12%), while 22 individuals (0.008%) were diagnosed with β-thal disease. A total of 5003 subjects (1.81%) were carrying the Sickle cell trait, while 172 subjects (0.062%) had Sickle cell disease including Sickle cell anemia (SCA). Results showed that the program succeeded indeed in preventing the marriage of 50.4% of risky couples by issuing unsafe marriage certificates. Yet more efforts are needed to improve the program’s main objective of decreasing high-risk marriages. In particular, health care systems should be ameliorated in a way to intensify the counselling mechanism for the high-risk couples, strengthen the awareness of the general population and induce earlier age screening policies. |
format | Online Article Text |
id | pubmed-8538810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85388102021-10-24 The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience Rouh AlDeen, Najat Osman, Asmaa A Alhabashi, Monira J Al Khaldi, Rasha Alawadi, Hassan Alromh, Maha K Alyafai, Eiman G Akbulut-Jeradi, Nagihan J Pers Med Article This study aims to estimate the prevalence rates of β-thalassemia and Sickle cell disorders in the adult population screened (n = 275,819) as part of the Kuwaiti National Premarital Screening Program. All the individuals who applied for a marriage license during the years 2009 and 2020 were covered by the program. A network of four reception centers in the Ministry of Health facilities and one Premarital Diagnostic Laboratory (PDL) in Maternity Hospital were involved in performing all investigations for hemoglobinopathies. The total number of individuals identified with β-thal trait was 5861 (2.12%), while 22 individuals (0.008%) were diagnosed with β-thal disease. A total of 5003 subjects (1.81%) were carrying the Sickle cell trait, while 172 subjects (0.062%) had Sickle cell disease including Sickle cell anemia (SCA). Results showed that the program succeeded indeed in preventing the marriage of 50.4% of risky couples by issuing unsafe marriage certificates. Yet more efforts are needed to improve the program’s main objective of decreasing high-risk marriages. In particular, health care systems should be ameliorated in a way to intensify the counselling mechanism for the high-risk couples, strengthen the awareness of the general population and induce earlier age screening policies. MDPI 2021-09-29 /pmc/articles/PMC8538810/ /pubmed/34683121 http://dx.doi.org/10.3390/jpm11100980 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rouh AlDeen, Najat Osman, Asmaa A Alhabashi, Monira J Al Khaldi, Rasha Alawadi, Hassan Alromh, Maha K Alyafai, Eiman G Akbulut-Jeradi, Nagihan The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience |
title | The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience |
title_full | The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience |
title_fullStr | The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience |
title_full_unstemmed | The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience |
title_short | The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience |
title_sort | prevalence of β-thalassemia and other hemoglobinopathies in kuwaiti premarital screening program: an 11-year experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538810/ https://www.ncbi.nlm.nih.gov/pubmed/34683121 http://dx.doi.org/10.3390/jpm11100980 |
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