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The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience

This study aims to estimate the prevalence rates of β-thalassemia and Sickle cell disorders in the adult population screened (n = 275,819) as part of the Kuwaiti National Premarital Screening Program. All the individuals who applied for a marriage license during the years 2009 and 2020 were covered...

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Autores principales: Rouh AlDeen, Najat, Osman, Asmaa A, Alhabashi, Monira J, Al Khaldi, Rasha, Alawadi, Hassan, Alromh, Maha K, Alyafai, Eiman G, Akbulut-Jeradi, Nagihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538810/
https://www.ncbi.nlm.nih.gov/pubmed/34683121
http://dx.doi.org/10.3390/jpm11100980
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author Rouh AlDeen, Najat
Osman, Asmaa A
Alhabashi, Monira J
Al Khaldi, Rasha
Alawadi, Hassan
Alromh, Maha K
Alyafai, Eiman G
Akbulut-Jeradi, Nagihan
author_facet Rouh AlDeen, Najat
Osman, Asmaa A
Alhabashi, Monira J
Al Khaldi, Rasha
Alawadi, Hassan
Alromh, Maha K
Alyafai, Eiman G
Akbulut-Jeradi, Nagihan
author_sort Rouh AlDeen, Najat
collection PubMed
description This study aims to estimate the prevalence rates of β-thalassemia and Sickle cell disorders in the adult population screened (n = 275,819) as part of the Kuwaiti National Premarital Screening Program. All the individuals who applied for a marriage license during the years 2009 and 2020 were covered by the program. A network of four reception centers in the Ministry of Health facilities and one Premarital Diagnostic Laboratory (PDL) in Maternity Hospital were involved in performing all investigations for hemoglobinopathies. The total number of individuals identified with β-thal trait was 5861 (2.12%), while 22 individuals (0.008%) were diagnosed with β-thal disease. A total of 5003 subjects (1.81%) were carrying the Sickle cell trait, while 172 subjects (0.062%) had Sickle cell disease including Sickle cell anemia (SCA). Results showed that the program succeeded indeed in preventing the marriage of 50.4% of risky couples by issuing unsafe marriage certificates. Yet more efforts are needed to improve the program’s main objective of decreasing high-risk marriages. In particular, health care systems should be ameliorated in a way to intensify the counselling mechanism for the high-risk couples, strengthen the awareness of the general population and induce earlier age screening policies.
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spelling pubmed-85388102021-10-24 The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience Rouh AlDeen, Najat Osman, Asmaa A Alhabashi, Monira J Al Khaldi, Rasha Alawadi, Hassan Alromh, Maha K Alyafai, Eiman G Akbulut-Jeradi, Nagihan J Pers Med Article This study aims to estimate the prevalence rates of β-thalassemia and Sickle cell disorders in the adult population screened (n = 275,819) as part of the Kuwaiti National Premarital Screening Program. All the individuals who applied for a marriage license during the years 2009 and 2020 were covered by the program. A network of four reception centers in the Ministry of Health facilities and one Premarital Diagnostic Laboratory (PDL) in Maternity Hospital were involved in performing all investigations for hemoglobinopathies. The total number of individuals identified with β-thal trait was 5861 (2.12%), while 22 individuals (0.008%) were diagnosed with β-thal disease. A total of 5003 subjects (1.81%) were carrying the Sickle cell trait, while 172 subjects (0.062%) had Sickle cell disease including Sickle cell anemia (SCA). Results showed that the program succeeded indeed in preventing the marriage of 50.4% of risky couples by issuing unsafe marriage certificates. Yet more efforts are needed to improve the program’s main objective of decreasing high-risk marriages. In particular, health care systems should be ameliorated in a way to intensify the counselling mechanism for the high-risk couples, strengthen the awareness of the general population and induce earlier age screening policies. MDPI 2021-09-29 /pmc/articles/PMC8538810/ /pubmed/34683121 http://dx.doi.org/10.3390/jpm11100980 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rouh AlDeen, Najat
Osman, Asmaa A
Alhabashi, Monira J
Al Khaldi, Rasha
Alawadi, Hassan
Alromh, Maha K
Alyafai, Eiman G
Akbulut-Jeradi, Nagihan
The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience
title The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience
title_full The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience
title_fullStr The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience
title_full_unstemmed The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience
title_short The Prevalence of β-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience
title_sort prevalence of β-thalassemia and other hemoglobinopathies in kuwaiti premarital screening program: an 11-year experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538810/
https://www.ncbi.nlm.nih.gov/pubmed/34683121
http://dx.doi.org/10.3390/jpm11100980
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