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Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin

Chemotherapy is one of the most effective treatments for cancer. However, intracellular delivery of many anticancer drugs is hindered by their hydrophobicity and low molecular weight. Here, we describe highly biocompatible and biodegradable amphiphilic vitamin conjugates comprising hydrophobic vitam...

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Autores principales: Ko, Na Re, Lee, Sang Ju, Chandrasekaran, Arun Pandian, Tyagi, Apoorvi, Ramakrishna, Suresh, Kim, Seog-Young, Kim, Do Won, Pack, Chan-Gi, Oh, Seung Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538907/
https://www.ncbi.nlm.nih.gov/pubmed/34681958
http://dx.doi.org/10.3390/ijms222011298
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author Ko, Na Re
Lee, Sang Ju
Chandrasekaran, Arun Pandian
Tyagi, Apoorvi
Ramakrishna, Suresh
Kim, Seog-Young
Kim, Do Won
Pack, Chan-Gi
Oh, Seung Jun
author_facet Ko, Na Re
Lee, Sang Ju
Chandrasekaran, Arun Pandian
Tyagi, Apoorvi
Ramakrishna, Suresh
Kim, Seog-Young
Kim, Do Won
Pack, Chan-Gi
Oh, Seung Jun
author_sort Ko, Na Re
collection PubMed
description Chemotherapy is one of the most effective treatments for cancer. However, intracellular delivery of many anticancer drugs is hindered by their hydrophobicity and low molecular weight. Here, we describe highly biocompatible and biodegradable amphiphilic vitamin conjugates comprising hydrophobic vitamin E and hydrophilic vitamin B labeled with dual pH and glutathione-responsive degradable linkages. Vitamin-based micelles (vitamicelles), formed by self-assembly in aqueous solutions, were optimized based on their stability after encapsulation of doxorubicin (DOX). The resulting vitamicelles have great potential as vehicles for anticancer drugs because they show excellent biocompatibility (>94% after 48 h of incubation) and rapid biodegradability (>90% after 2.5 h). Compared with free DOX, DOX-loaded vitamicelles showed a markedly enhanced anticancer effect as they released the drug rapidly and inhibited drug efflux out of cells efficiently. By exploiting these advantages, this study not only provides a promising strategy for circumventing existing challenges regarding the delivery of anticancer drugs but also extends the utility of current DOX-induced chemotherapy.
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spelling pubmed-85389072021-10-24 Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin Ko, Na Re Lee, Sang Ju Chandrasekaran, Arun Pandian Tyagi, Apoorvi Ramakrishna, Suresh Kim, Seog-Young Kim, Do Won Pack, Chan-Gi Oh, Seung Jun Int J Mol Sci Article Chemotherapy is one of the most effective treatments for cancer. However, intracellular delivery of many anticancer drugs is hindered by their hydrophobicity and low molecular weight. Here, we describe highly biocompatible and biodegradable amphiphilic vitamin conjugates comprising hydrophobic vitamin E and hydrophilic vitamin B labeled with dual pH and glutathione-responsive degradable linkages. Vitamin-based micelles (vitamicelles), formed by self-assembly in aqueous solutions, were optimized based on their stability after encapsulation of doxorubicin (DOX). The resulting vitamicelles have great potential as vehicles for anticancer drugs because they show excellent biocompatibility (>94% after 48 h of incubation) and rapid biodegradability (>90% after 2.5 h). Compared with free DOX, DOX-loaded vitamicelles showed a markedly enhanced anticancer effect as they released the drug rapidly and inhibited drug efflux out of cells efficiently. By exploiting these advantages, this study not only provides a promising strategy for circumventing existing challenges regarding the delivery of anticancer drugs but also extends the utility of current DOX-induced chemotherapy. MDPI 2021-10-19 /pmc/articles/PMC8538907/ /pubmed/34681958 http://dx.doi.org/10.3390/ijms222011298 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ko, Na Re
Lee, Sang Ju
Chandrasekaran, Arun Pandian
Tyagi, Apoorvi
Ramakrishna, Suresh
Kim, Seog-Young
Kim, Do Won
Pack, Chan-Gi
Oh, Seung Jun
Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin
title Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin
title_full Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin
title_fullStr Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin
title_full_unstemmed Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin
title_short Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin
title_sort smart vitamin micelles as cancer nanomedicines for enhanced intracellular delivery of doxorubicin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538907/
https://www.ncbi.nlm.nih.gov/pubmed/34681958
http://dx.doi.org/10.3390/ijms222011298
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