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Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin
Chemotherapy is one of the most effective treatments for cancer. However, intracellular delivery of many anticancer drugs is hindered by their hydrophobicity and low molecular weight. Here, we describe highly biocompatible and biodegradable amphiphilic vitamin conjugates comprising hydrophobic vitam...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538907/ https://www.ncbi.nlm.nih.gov/pubmed/34681958 http://dx.doi.org/10.3390/ijms222011298 |
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author | Ko, Na Re Lee, Sang Ju Chandrasekaran, Arun Pandian Tyagi, Apoorvi Ramakrishna, Suresh Kim, Seog-Young Kim, Do Won Pack, Chan-Gi Oh, Seung Jun |
author_facet | Ko, Na Re Lee, Sang Ju Chandrasekaran, Arun Pandian Tyagi, Apoorvi Ramakrishna, Suresh Kim, Seog-Young Kim, Do Won Pack, Chan-Gi Oh, Seung Jun |
author_sort | Ko, Na Re |
collection | PubMed |
description | Chemotherapy is one of the most effective treatments for cancer. However, intracellular delivery of many anticancer drugs is hindered by their hydrophobicity and low molecular weight. Here, we describe highly biocompatible and biodegradable amphiphilic vitamin conjugates comprising hydrophobic vitamin E and hydrophilic vitamin B labeled with dual pH and glutathione-responsive degradable linkages. Vitamin-based micelles (vitamicelles), formed by self-assembly in aqueous solutions, were optimized based on their stability after encapsulation of doxorubicin (DOX). The resulting vitamicelles have great potential as vehicles for anticancer drugs because they show excellent biocompatibility (>94% after 48 h of incubation) and rapid biodegradability (>90% after 2.5 h). Compared with free DOX, DOX-loaded vitamicelles showed a markedly enhanced anticancer effect as they released the drug rapidly and inhibited drug efflux out of cells efficiently. By exploiting these advantages, this study not only provides a promising strategy for circumventing existing challenges regarding the delivery of anticancer drugs but also extends the utility of current DOX-induced chemotherapy. |
format | Online Article Text |
id | pubmed-8538907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85389072021-10-24 Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin Ko, Na Re Lee, Sang Ju Chandrasekaran, Arun Pandian Tyagi, Apoorvi Ramakrishna, Suresh Kim, Seog-Young Kim, Do Won Pack, Chan-Gi Oh, Seung Jun Int J Mol Sci Article Chemotherapy is one of the most effective treatments for cancer. However, intracellular delivery of many anticancer drugs is hindered by their hydrophobicity and low molecular weight. Here, we describe highly biocompatible and biodegradable amphiphilic vitamin conjugates comprising hydrophobic vitamin E and hydrophilic vitamin B labeled with dual pH and glutathione-responsive degradable linkages. Vitamin-based micelles (vitamicelles), formed by self-assembly in aqueous solutions, were optimized based on their stability after encapsulation of doxorubicin (DOX). The resulting vitamicelles have great potential as vehicles for anticancer drugs because they show excellent biocompatibility (>94% after 48 h of incubation) and rapid biodegradability (>90% after 2.5 h). Compared with free DOX, DOX-loaded vitamicelles showed a markedly enhanced anticancer effect as they released the drug rapidly and inhibited drug efflux out of cells efficiently. By exploiting these advantages, this study not only provides a promising strategy for circumventing existing challenges regarding the delivery of anticancer drugs but also extends the utility of current DOX-induced chemotherapy. MDPI 2021-10-19 /pmc/articles/PMC8538907/ /pubmed/34681958 http://dx.doi.org/10.3390/ijms222011298 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ko, Na Re Lee, Sang Ju Chandrasekaran, Arun Pandian Tyagi, Apoorvi Ramakrishna, Suresh Kim, Seog-Young Kim, Do Won Pack, Chan-Gi Oh, Seung Jun Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin |
title | Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin |
title_full | Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin |
title_fullStr | Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin |
title_full_unstemmed | Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin |
title_short | Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin |
title_sort | smart vitamin micelles as cancer nanomedicines for enhanced intracellular delivery of doxorubicin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538907/ https://www.ncbi.nlm.nih.gov/pubmed/34681958 http://dx.doi.org/10.3390/ijms222011298 |
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