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Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review

Chronic hepatitis B (CHB) is an infectious viral disease that is prevalent worldwide. Traditional nucleoside analogues, as well as the novel drug targets against hepatitis B virus (HBV), are associated with certain critical factors that influence the curative effect, such as biological stability and...

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Detalles Bibliográficos
Autores principales: Miao, Jing, Gao, Peng, Li, Qian, He, Kaifeng, Zhang, Liwen, Wang, Junyan, Huang, Lingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538950/
https://www.ncbi.nlm.nih.gov/pubmed/34681886
http://dx.doi.org/10.3390/ijms222011227
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author Miao, Jing
Gao, Peng
Li, Qian
He, Kaifeng
Zhang, Liwen
Wang, Junyan
Huang, Lingfei
author_facet Miao, Jing
Gao, Peng
Li, Qian
He, Kaifeng
Zhang, Liwen
Wang, Junyan
Huang, Lingfei
author_sort Miao, Jing
collection PubMed
description Chronic hepatitis B (CHB) is an infectious viral disease that is prevalent worldwide. Traditional nucleoside analogues, as well as the novel drug targets against hepatitis B virus (HBV), are associated with certain critical factors that influence the curative effect, such as biological stability and safety, effective drug delivery, and controlled release. Nanoparticle drug delivery systems have significant advantages and have provided a basis for the development of anti-HBV strategies. In this review, we aim to review the advances in nanoparticle drug delivery systems for anti-hepatitis B virus therapy by summarizing the relevant literature. First, we focus on the characteristics of nanoparticle drug delivery systems for anti-HBV therapy. Second, we discuss the nanoparticle delivery systems for anti-HBV nucleoside drugs, gene-based drugs, and vaccines. Lastly, we provide an overview of the prospects for nanoparticle-based anti-HBV agents.
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spelling pubmed-85389502021-10-24 Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review Miao, Jing Gao, Peng Li, Qian He, Kaifeng Zhang, Liwen Wang, Junyan Huang, Lingfei Int J Mol Sci Review Chronic hepatitis B (CHB) is an infectious viral disease that is prevalent worldwide. Traditional nucleoside analogues, as well as the novel drug targets against hepatitis B virus (HBV), are associated with certain critical factors that influence the curative effect, such as biological stability and safety, effective drug delivery, and controlled release. Nanoparticle drug delivery systems have significant advantages and have provided a basis for the development of anti-HBV strategies. In this review, we aim to review the advances in nanoparticle drug delivery systems for anti-hepatitis B virus therapy by summarizing the relevant literature. First, we focus on the characteristics of nanoparticle drug delivery systems for anti-HBV therapy. Second, we discuss the nanoparticle delivery systems for anti-HBV nucleoside drugs, gene-based drugs, and vaccines. Lastly, we provide an overview of the prospects for nanoparticle-based anti-HBV agents. MDPI 2021-10-18 /pmc/articles/PMC8538950/ /pubmed/34681886 http://dx.doi.org/10.3390/ijms222011227 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Miao, Jing
Gao, Peng
Li, Qian
He, Kaifeng
Zhang, Liwen
Wang, Junyan
Huang, Lingfei
Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review
title Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review
title_full Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review
title_fullStr Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review
title_full_unstemmed Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review
title_short Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review
title_sort advances in nanoparticle drug delivery systems for anti-hepatitis b virus therapy: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538950/
https://www.ncbi.nlm.nih.gov/pubmed/34681886
http://dx.doi.org/10.3390/ijms222011227
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