Cargando…
SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives
SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. Th...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539008/ https://www.ncbi.nlm.nih.gov/pubmed/34696353 http://dx.doi.org/10.3390/v13101923 |
| _version_ | 1784588642862235648 |
|---|---|
| author | Long, Samuel |
| author_facet | Long, Samuel |
| author_sort | Long, Samuel |
| collection | PubMed |
| description | SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. This review summarizes the recent progress on SARS-CoV-2 sgRNA identification, characterization, and application as a viral replication marker. The significance of these findings and potential future research areas of interest are discussed. |
| format | Online Article Text |
| id | pubmed-8539008 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85390082021-10-24 SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives Long, Samuel Viruses Review SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. This review summarizes the recent progress on SARS-CoV-2 sgRNA identification, characterization, and application as a viral replication marker. The significance of these findings and potential future research areas of interest are discussed. MDPI 2021-09-24 /pmc/articles/PMC8539008/ /pubmed/34696353 http://dx.doi.org/10.3390/v13101923 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Long, Samuel SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives |
| title | SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives |
| title_full | SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives |
| title_fullStr | SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives |
| title_full_unstemmed | SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives |
| title_short | SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives |
| title_sort | sars-cov-2 subgenomic rnas: characterization, utility, and perspectives |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539008/ https://www.ncbi.nlm.nih.gov/pubmed/34696353 http://dx.doi.org/10.3390/v13101923 |
| work_keys_str_mv | AT longsamuel sarscov2subgenomicrnascharacterizationutilityandperspectives |