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Low Prevalence of HEV Infection and No Associated Risk of HEV Transmission from Mother to Child among Pregnant Women in Vietnam

Infections with HEV in low- and middle-income countries (LMICs) are associated with increased rates of preterm birth, miscarriage, and stillbirth. The aim of the present study was to investigate HEV infections in pregnant women and the possibility of mother-to-child transmission, and associated outc...

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Autores principales: Huy, Pham Xuan, Chung, Dang Thanh, Linh, Dang Thuy, Hang, Ngo Thu, Rachakonda, Sivaramakrishna, Pallerla, Srinivas Reddy, Linh, Le Thi Kieu, Tong, Hoang Van, Dung, Le Minh, Mao, Can Van, Wedemeyer, Heiner, Bock, C-Thomas, Kremsner, Peter G., Song, Le Huu, Sy, Bui Tien, Toan, Nguyen Linh, Velavan, Thirumalaisamy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539026/
https://www.ncbi.nlm.nih.gov/pubmed/34684289
http://dx.doi.org/10.3390/pathogens10101340
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author Huy, Pham Xuan
Chung, Dang Thanh
Linh, Dang Thuy
Hang, Ngo Thu
Rachakonda, Sivaramakrishna
Pallerla, Srinivas Reddy
Linh, Le Thi Kieu
Tong, Hoang Van
Dung, Le Minh
Mao, Can Van
Wedemeyer, Heiner
Bock, C-Thomas
Kremsner, Peter G.
Song, Le Huu
Sy, Bui Tien
Toan, Nguyen Linh
Velavan, Thirumalaisamy P.
author_facet Huy, Pham Xuan
Chung, Dang Thanh
Linh, Dang Thuy
Hang, Ngo Thu
Rachakonda, Sivaramakrishna
Pallerla, Srinivas Reddy
Linh, Le Thi Kieu
Tong, Hoang Van
Dung, Le Minh
Mao, Can Van
Wedemeyer, Heiner
Bock, C-Thomas
Kremsner, Peter G.
Song, Le Huu
Sy, Bui Tien
Toan, Nguyen Linh
Velavan, Thirumalaisamy P.
author_sort Huy, Pham Xuan
collection PubMed
description Infections with HEV in low- and middle-income countries (LMICs) are associated with increased rates of preterm birth, miscarriage, and stillbirth. The aim of the present study was to investigate HEV infections in pregnant women and the possibility of mother-to-child transmission, and associated outcomes. A total of 183 pregnant women in their third trimester were recruited and followed until delivery. Anti-HEV IgG and IgM were determined via enzyme-linked immunosorbent assay (ELISA), and HEV nucleic acids were detected in stool and cord blood samples. HEV genotypes were identified by Sanger sequencing, and phylogenetic analyses were performed. Mother-to-child transmission and associated adverse outcomes were not observed. Only 2% of patients (n = 4/183) tested positive for anti-HEV IgM, and 8% (n = 14/183) tested positive for anti-HEV IgG antibodies. Cord blood (n = 150) analysis showed that there was no IgM detected, while 4% (n = 6/150) tested positive for anti-HEV IgG, which was consistent with mothers testing positive for anti-HEV IgG. Nucleic acid tests for HEV RNA yielded 2% (n = 4/183) from the serum and stool of pregnant women, and none from cord blood. The HEV isolates belonged to the genotype HEV-3a, with 99% homology with humans and 96% with pigs. No association was found between the risk of HEV infection and pregnancy outcomes or HEV transmission from mother to child. HEV-3 infections of zoonotic origin in pregnancy might have eventually resolved without complications.
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spelling pubmed-85390262021-10-24 Low Prevalence of HEV Infection and No Associated Risk of HEV Transmission from Mother to Child among Pregnant Women in Vietnam Huy, Pham Xuan Chung, Dang Thanh Linh, Dang Thuy Hang, Ngo Thu Rachakonda, Sivaramakrishna Pallerla, Srinivas Reddy Linh, Le Thi Kieu Tong, Hoang Van Dung, Le Minh Mao, Can Van Wedemeyer, Heiner Bock, C-Thomas Kremsner, Peter G. Song, Le Huu Sy, Bui Tien Toan, Nguyen Linh Velavan, Thirumalaisamy P. Pathogens Article Infections with HEV in low- and middle-income countries (LMICs) are associated with increased rates of preterm birth, miscarriage, and stillbirth. The aim of the present study was to investigate HEV infections in pregnant women and the possibility of mother-to-child transmission, and associated outcomes. A total of 183 pregnant women in their third trimester were recruited and followed until delivery. Anti-HEV IgG and IgM were determined via enzyme-linked immunosorbent assay (ELISA), and HEV nucleic acids were detected in stool and cord blood samples. HEV genotypes were identified by Sanger sequencing, and phylogenetic analyses were performed. Mother-to-child transmission and associated adverse outcomes were not observed. Only 2% of patients (n = 4/183) tested positive for anti-HEV IgM, and 8% (n = 14/183) tested positive for anti-HEV IgG antibodies. Cord blood (n = 150) analysis showed that there was no IgM detected, while 4% (n = 6/150) tested positive for anti-HEV IgG, which was consistent with mothers testing positive for anti-HEV IgG. Nucleic acid tests for HEV RNA yielded 2% (n = 4/183) from the serum and stool of pregnant women, and none from cord blood. The HEV isolates belonged to the genotype HEV-3a, with 99% homology with humans and 96% with pigs. No association was found between the risk of HEV infection and pregnancy outcomes or HEV transmission from mother to child. HEV-3 infections of zoonotic origin in pregnancy might have eventually resolved without complications. MDPI 2021-10-17 /pmc/articles/PMC8539026/ /pubmed/34684289 http://dx.doi.org/10.3390/pathogens10101340 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huy, Pham Xuan
Chung, Dang Thanh
Linh, Dang Thuy
Hang, Ngo Thu
Rachakonda, Sivaramakrishna
Pallerla, Srinivas Reddy
Linh, Le Thi Kieu
Tong, Hoang Van
Dung, Le Minh
Mao, Can Van
Wedemeyer, Heiner
Bock, C-Thomas
Kremsner, Peter G.
Song, Le Huu
Sy, Bui Tien
Toan, Nguyen Linh
Velavan, Thirumalaisamy P.
Low Prevalence of HEV Infection and No Associated Risk of HEV Transmission from Mother to Child among Pregnant Women in Vietnam
title Low Prevalence of HEV Infection and No Associated Risk of HEV Transmission from Mother to Child among Pregnant Women in Vietnam
title_full Low Prevalence of HEV Infection and No Associated Risk of HEV Transmission from Mother to Child among Pregnant Women in Vietnam
title_fullStr Low Prevalence of HEV Infection and No Associated Risk of HEV Transmission from Mother to Child among Pregnant Women in Vietnam
title_full_unstemmed Low Prevalence of HEV Infection and No Associated Risk of HEV Transmission from Mother to Child among Pregnant Women in Vietnam
title_short Low Prevalence of HEV Infection and No Associated Risk of HEV Transmission from Mother to Child among Pregnant Women in Vietnam
title_sort low prevalence of hev infection and no associated risk of hev transmission from mother to child among pregnant women in vietnam
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539026/
https://www.ncbi.nlm.nih.gov/pubmed/34684289
http://dx.doi.org/10.3390/pathogens10101340
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