Cargando…
Altered SERCA Expression in Breast Cancer
Background and Objectives: Calcium (Ca(2+)) signaling is critical for the normal functioning of various cellular activities. However, abnormal changes in cellular Ca(2+) can contribute to pathological conditions, including various types of cancer. The maintenance of intracellular Ca(2+) levels is ac...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539028/ https://www.ncbi.nlm.nih.gov/pubmed/34684111 http://dx.doi.org/10.3390/medicina57101074 |
Sumario: | Background and Objectives: Calcium (Ca(2+)) signaling is critical for the normal functioning of various cellular activities. However, abnormal changes in cellular Ca(2+) can contribute to pathological conditions, including various types of cancer. The maintenance of intracellular Ca(2+) levels is achieved through tightly regulated processes that help maintain Ca(2+) homeostasis. Several types of regulatory proteins are involved in controlling intracellular Ca(2+) levels, including the sarco/endoplasmic reticulum (SR/ER) Ca(2+) ATPase pump (SERCA), which maintains Ca(2+) levels released from the SR/ER. In total, three ATPase SR/ER Ca(2+)-transporting (ATP2A) 1-3 genes exist, which encode for several isoforms whose expression profiles are tissue-specific. Recently, it has become clear that abnormal SERCA expression and activity are associated with various types of cancer, including breast cancer. Breast carcinomas represent 40% of all cancer types that affect women, with a wide variety of pathological and clinical conditions. Materials and methods: Using cBioPortal breast cancer patient data, Kaplan–Meier plots demonstrated that high ATP2A1 and ATP2A3 expression was associated with reduced patient survival. Results: The present study found significantly different SERCA specific-type expressions in a series of breast cancer cell lines. Moreover, bioinformatics analysis indicated that ATP2A1 and ATP2A3 expression was highly altered in patients with breast cancer. Conclusion: Overall, the present data suggest that SERCA gene-specific expressioncan possibly be considered as a crucial target for the control of breast cancer development and progression. |
---|