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Altered SERCA Expression in Breast Cancer
Background and Objectives: Calcium (Ca(2+)) signaling is critical for the normal functioning of various cellular activities. However, abnormal changes in cellular Ca(2+) can contribute to pathological conditions, including various types of cancer. The maintenance of intracellular Ca(2+) levels is ac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539028/ https://www.ncbi.nlm.nih.gov/pubmed/34684111 http://dx.doi.org/10.3390/medicina57101074 |
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author | Christodoulou, Panayiota Yiallouris, Andreas Michail, Artemis Christodoulou, Maria-Ioanna Politis, Panagiotis K. Patrikios, Ioannis |
author_facet | Christodoulou, Panayiota Yiallouris, Andreas Michail, Artemis Christodoulou, Maria-Ioanna Politis, Panagiotis K. Patrikios, Ioannis |
author_sort | Christodoulou, Panayiota |
collection | PubMed |
description | Background and Objectives: Calcium (Ca(2+)) signaling is critical for the normal functioning of various cellular activities. However, abnormal changes in cellular Ca(2+) can contribute to pathological conditions, including various types of cancer. The maintenance of intracellular Ca(2+) levels is achieved through tightly regulated processes that help maintain Ca(2+) homeostasis. Several types of regulatory proteins are involved in controlling intracellular Ca(2+) levels, including the sarco/endoplasmic reticulum (SR/ER) Ca(2+) ATPase pump (SERCA), which maintains Ca(2+) levels released from the SR/ER. In total, three ATPase SR/ER Ca(2+)-transporting (ATP2A) 1-3 genes exist, which encode for several isoforms whose expression profiles are tissue-specific. Recently, it has become clear that abnormal SERCA expression and activity are associated with various types of cancer, including breast cancer. Breast carcinomas represent 40% of all cancer types that affect women, with a wide variety of pathological and clinical conditions. Materials and methods: Using cBioPortal breast cancer patient data, Kaplan–Meier plots demonstrated that high ATP2A1 and ATP2A3 expression was associated with reduced patient survival. Results: The present study found significantly different SERCA specific-type expressions in a series of breast cancer cell lines. Moreover, bioinformatics analysis indicated that ATP2A1 and ATP2A3 expression was highly altered in patients with breast cancer. Conclusion: Overall, the present data suggest that SERCA gene-specific expressioncan possibly be considered as a crucial target for the control of breast cancer development and progression. |
format | Online Article Text |
id | pubmed-8539028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85390282021-10-24 Altered SERCA Expression in Breast Cancer Christodoulou, Panayiota Yiallouris, Andreas Michail, Artemis Christodoulou, Maria-Ioanna Politis, Panagiotis K. Patrikios, Ioannis Medicina (Kaunas) Article Background and Objectives: Calcium (Ca(2+)) signaling is critical for the normal functioning of various cellular activities. However, abnormal changes in cellular Ca(2+) can contribute to pathological conditions, including various types of cancer. The maintenance of intracellular Ca(2+) levels is achieved through tightly regulated processes that help maintain Ca(2+) homeostasis. Several types of regulatory proteins are involved in controlling intracellular Ca(2+) levels, including the sarco/endoplasmic reticulum (SR/ER) Ca(2+) ATPase pump (SERCA), which maintains Ca(2+) levels released from the SR/ER. In total, three ATPase SR/ER Ca(2+)-transporting (ATP2A) 1-3 genes exist, which encode for several isoforms whose expression profiles are tissue-specific. Recently, it has become clear that abnormal SERCA expression and activity are associated with various types of cancer, including breast cancer. Breast carcinomas represent 40% of all cancer types that affect women, with a wide variety of pathological and clinical conditions. Materials and methods: Using cBioPortal breast cancer patient data, Kaplan–Meier plots demonstrated that high ATP2A1 and ATP2A3 expression was associated with reduced patient survival. Results: The present study found significantly different SERCA specific-type expressions in a series of breast cancer cell lines. Moreover, bioinformatics analysis indicated that ATP2A1 and ATP2A3 expression was highly altered in patients with breast cancer. Conclusion: Overall, the present data suggest that SERCA gene-specific expressioncan possibly be considered as a crucial target for the control of breast cancer development and progression. MDPI 2021-10-08 /pmc/articles/PMC8539028/ /pubmed/34684111 http://dx.doi.org/10.3390/medicina57101074 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Christodoulou, Panayiota Yiallouris, Andreas Michail, Artemis Christodoulou, Maria-Ioanna Politis, Panagiotis K. Patrikios, Ioannis Altered SERCA Expression in Breast Cancer |
title | Altered SERCA Expression in Breast Cancer |
title_full | Altered SERCA Expression in Breast Cancer |
title_fullStr | Altered SERCA Expression in Breast Cancer |
title_full_unstemmed | Altered SERCA Expression in Breast Cancer |
title_short | Altered SERCA Expression in Breast Cancer |
title_sort | altered serca expression in breast cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539028/ https://www.ncbi.nlm.nih.gov/pubmed/34684111 http://dx.doi.org/10.3390/medicina57101074 |
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