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Altered SERCA Expression in Breast Cancer

Background and Objectives: Calcium (Ca(2+)) signaling is critical for the normal functioning of various cellular activities. However, abnormal changes in cellular Ca(2+) can contribute to pathological conditions, including various types of cancer. The maintenance of intracellular Ca(2+) levels is ac...

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Autores principales: Christodoulou, Panayiota, Yiallouris, Andreas, Michail, Artemis, Christodoulou, Maria-Ioanna, Politis, Panagiotis K., Patrikios, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539028/
https://www.ncbi.nlm.nih.gov/pubmed/34684111
http://dx.doi.org/10.3390/medicina57101074
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author Christodoulou, Panayiota
Yiallouris, Andreas
Michail, Artemis
Christodoulou, Maria-Ioanna
Politis, Panagiotis K.
Patrikios, Ioannis
author_facet Christodoulou, Panayiota
Yiallouris, Andreas
Michail, Artemis
Christodoulou, Maria-Ioanna
Politis, Panagiotis K.
Patrikios, Ioannis
author_sort Christodoulou, Panayiota
collection PubMed
description Background and Objectives: Calcium (Ca(2+)) signaling is critical for the normal functioning of various cellular activities. However, abnormal changes in cellular Ca(2+) can contribute to pathological conditions, including various types of cancer. The maintenance of intracellular Ca(2+) levels is achieved through tightly regulated processes that help maintain Ca(2+) homeostasis. Several types of regulatory proteins are involved in controlling intracellular Ca(2+) levels, including the sarco/endoplasmic reticulum (SR/ER) Ca(2+) ATPase pump (SERCA), which maintains Ca(2+) levels released from the SR/ER. In total, three ATPase SR/ER Ca(2+)-transporting (ATP2A) 1-3 genes exist, which encode for several isoforms whose expression profiles are tissue-specific. Recently, it has become clear that abnormal SERCA expression and activity are associated with various types of cancer, including breast cancer. Breast carcinomas represent 40% of all cancer types that affect women, with a wide variety of pathological and clinical conditions. Materials and methods: Using cBioPortal breast cancer patient data, Kaplan–Meier plots demonstrated that high ATP2A1 and ATP2A3 expression was associated with reduced patient survival. Results: The present study found significantly different SERCA specific-type expressions in a series of breast cancer cell lines. Moreover, bioinformatics analysis indicated that ATP2A1 and ATP2A3 expression was highly altered in patients with breast cancer. Conclusion: Overall, the present data suggest that SERCA gene-specific expressioncan possibly be considered as a crucial target for the control of breast cancer development and progression.
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spelling pubmed-85390282021-10-24 Altered SERCA Expression in Breast Cancer Christodoulou, Panayiota Yiallouris, Andreas Michail, Artemis Christodoulou, Maria-Ioanna Politis, Panagiotis K. Patrikios, Ioannis Medicina (Kaunas) Article Background and Objectives: Calcium (Ca(2+)) signaling is critical for the normal functioning of various cellular activities. However, abnormal changes in cellular Ca(2+) can contribute to pathological conditions, including various types of cancer. The maintenance of intracellular Ca(2+) levels is achieved through tightly regulated processes that help maintain Ca(2+) homeostasis. Several types of regulatory proteins are involved in controlling intracellular Ca(2+) levels, including the sarco/endoplasmic reticulum (SR/ER) Ca(2+) ATPase pump (SERCA), which maintains Ca(2+) levels released from the SR/ER. In total, three ATPase SR/ER Ca(2+)-transporting (ATP2A) 1-3 genes exist, which encode for several isoforms whose expression profiles are tissue-specific. Recently, it has become clear that abnormal SERCA expression and activity are associated with various types of cancer, including breast cancer. Breast carcinomas represent 40% of all cancer types that affect women, with a wide variety of pathological and clinical conditions. Materials and methods: Using cBioPortal breast cancer patient data, Kaplan–Meier plots demonstrated that high ATP2A1 and ATP2A3 expression was associated with reduced patient survival. Results: The present study found significantly different SERCA specific-type expressions in a series of breast cancer cell lines. Moreover, bioinformatics analysis indicated that ATP2A1 and ATP2A3 expression was highly altered in patients with breast cancer. Conclusion: Overall, the present data suggest that SERCA gene-specific expressioncan possibly be considered as a crucial target for the control of breast cancer development and progression. MDPI 2021-10-08 /pmc/articles/PMC8539028/ /pubmed/34684111 http://dx.doi.org/10.3390/medicina57101074 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Christodoulou, Panayiota
Yiallouris, Andreas
Michail, Artemis
Christodoulou, Maria-Ioanna
Politis, Panagiotis K.
Patrikios, Ioannis
Altered SERCA Expression in Breast Cancer
title Altered SERCA Expression in Breast Cancer
title_full Altered SERCA Expression in Breast Cancer
title_fullStr Altered SERCA Expression in Breast Cancer
title_full_unstemmed Altered SERCA Expression in Breast Cancer
title_short Altered SERCA Expression in Breast Cancer
title_sort altered serca expression in breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539028/
https://www.ncbi.nlm.nih.gov/pubmed/34684111
http://dx.doi.org/10.3390/medicina57101074
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