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A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring
The screening of hundreds of substances belonging to multiple chemical classes in liver is required in areas such as food safety or biomonitoring. We adapted a previous QuEChERS-based method in blood to the liver matrix and applied to these fields of study. The validation of the method allowed the i...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539179/ https://www.ncbi.nlm.nih.gov/pubmed/34678934 http://dx.doi.org/10.3390/toxics9100238 |
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author | Rial-Berriel, Cristian Acosta-Dacal, Andrea Zumbado, Manuel Henríquez-Hernández, Luis Alberto Rodríguez-Hernández, Ángel Macías-Montes, Ana Boada, Luis D. Travieso-Aja, María del Mar Martin Cruz, Beatriz Luzardo, Octavio P. |
author_facet | Rial-Berriel, Cristian Acosta-Dacal, Andrea Zumbado, Manuel Henríquez-Hernández, Luis Alberto Rodríguez-Hernández, Ángel Macías-Montes, Ana Boada, Luis D. Travieso-Aja, María del Mar Martin Cruz, Beatriz Luzardo, Octavio P. |
author_sort | Rial-Berriel, Cristian |
collection | PubMed |
description | The screening of hundreds of substances belonging to multiple chemical classes in liver is required in areas such as food safety or biomonitoring. We adapted a previous QuEChERS-based method in blood to the liver matrix and applied to these fields of study. The validation of the method allowed the inclusion of 351 contaminants, 80% with a LOQ < 2 ng/g. In the analysis of 42 consumer liver samples, we detected trace levels of 29 different contaminants. The most frequent and concentrated was 4,4’-DDE. POPs accounted for 66% of the compounds detected. In no case was the MRL reached for any of the contaminants detected. We also applied the method to 151 livers of wild birds to perform a biomonitoring pilot study in the Canary Islands. We detected 52 contaminants in 15 bird species. These were also mostly POPs, although high frequencies and concentrations of anticoagulant rodenticides (AR) and some other agricultural pesticides also stand out. POPs and AR contamination levels were significantly higher in terrestrial birds, raptors and particularly in nocturnal birds. Pesticide contamination levels were also higher in terrestrial birds, as well as in non-raptors and diurnal birds. The validated method is simple, robust, and sensitive and performs well in a variety of practical scenarios, where it can be carried out relatively quickly and inexpensively. |
format | Online Article Text |
id | pubmed-8539179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85391792021-10-24 A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring Rial-Berriel, Cristian Acosta-Dacal, Andrea Zumbado, Manuel Henríquez-Hernández, Luis Alberto Rodríguez-Hernández, Ángel Macías-Montes, Ana Boada, Luis D. Travieso-Aja, María del Mar Martin Cruz, Beatriz Luzardo, Octavio P. Toxics Article The screening of hundreds of substances belonging to multiple chemical classes in liver is required in areas such as food safety or biomonitoring. We adapted a previous QuEChERS-based method in blood to the liver matrix and applied to these fields of study. The validation of the method allowed the inclusion of 351 contaminants, 80% with a LOQ < 2 ng/g. In the analysis of 42 consumer liver samples, we detected trace levels of 29 different contaminants. The most frequent and concentrated was 4,4’-DDE. POPs accounted for 66% of the compounds detected. In no case was the MRL reached for any of the contaminants detected. We also applied the method to 151 livers of wild birds to perform a biomonitoring pilot study in the Canary Islands. We detected 52 contaminants in 15 bird species. These were also mostly POPs, although high frequencies and concentrations of anticoagulant rodenticides (AR) and some other agricultural pesticides also stand out. POPs and AR contamination levels were significantly higher in terrestrial birds, raptors and particularly in nocturnal birds. Pesticide contamination levels were also higher in terrestrial birds, as well as in non-raptors and diurnal birds. The validated method is simple, robust, and sensitive and performs well in a variety of practical scenarios, where it can be carried out relatively quickly and inexpensively. MDPI 2021-09-27 /pmc/articles/PMC8539179/ /pubmed/34678934 http://dx.doi.org/10.3390/toxics9100238 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rial-Berriel, Cristian Acosta-Dacal, Andrea Zumbado, Manuel Henríquez-Hernández, Luis Alberto Rodríguez-Hernández, Ángel Macías-Montes, Ana Boada, Luis D. Travieso-Aja, María del Mar Martin Cruz, Beatriz Luzardo, Octavio P. A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring |
title | A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring |
title_full | A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring |
title_fullStr | A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring |
title_full_unstemmed | A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring |
title_short | A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring |
title_sort | method scope extension for the simultaneous analysis of pops, current-use and banned pesticides, rodenticides, and pharmaceuticals in liver. application to food safety and biomonitoring |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539179/ https://www.ncbi.nlm.nih.gov/pubmed/34678934 http://dx.doi.org/10.3390/toxics9100238 |
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