Krüppel-like Factor 2 (KLF2) in Immune Cell Migration

Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell migration and homing. We summarize the key fu...

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Detalles Bibliográficos
Autores principales: Wittner, Jens, Schuh, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539188/
https://www.ncbi.nlm.nih.gov/pubmed/34696279
http://dx.doi.org/10.3390/vaccines9101171
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author Wittner, Jens
Schuh, Wolfgang
author_facet Wittner, Jens
Schuh, Wolfgang
author_sort Wittner, Jens
collection PubMed
description Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell migration and homing. We summarize the key functions of KLF2 in the regulation of chemokine receptors and adhesion molecules and discuss the relevance of the KLF2-mediated control of immune cell migration in the context of immune responses, infections, and diseases.
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spelling pubmed-85391882021-10-24 Krüppel-like Factor 2 (KLF2) in Immune Cell Migration Wittner, Jens Schuh, Wolfgang Vaccines (Basel) Review Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell migration and homing. We summarize the key functions of KLF2 in the regulation of chemokine receptors and adhesion molecules and discuss the relevance of the KLF2-mediated control of immune cell migration in the context of immune responses, infections, and diseases. MDPI 2021-10-13 /pmc/articles/PMC8539188/ /pubmed/34696279 http://dx.doi.org/10.3390/vaccines9101171 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wittner, Jens
Schuh, Wolfgang
Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
title Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
title_full Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
title_fullStr Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
title_full_unstemmed Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
title_short Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
title_sort krüppel-like factor 2 (klf2) in immune cell migration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539188/
https://www.ncbi.nlm.nih.gov/pubmed/34696279
http://dx.doi.org/10.3390/vaccines9101171
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