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Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease

Background and Objectives: Anemia is the most frequent complication of inflammatory bowel diseases. Clinically, anemia can affect important quality-of-life (QoL) components, such as exercise capacity, cognitive function, and the ability to carry out social activities. The disease activity has a sign...

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Autores principales: Dranga, Mihaela, Boiculese, Lucian Vasile, Popa, Iolanda Valentina, Floria, Mariana, Gavril, Oana Irina, Bărboi, Oana-Bogdana, Trifan, Anca, Cijevschi Prelipcean, Cristina, Mihai, Cătălina, Gavrilescu, Otilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539193/
https://www.ncbi.nlm.nih.gov/pubmed/34684083
http://dx.doi.org/10.3390/medicina57101046
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author Dranga, Mihaela
Boiculese, Lucian Vasile
Popa, Iolanda Valentina
Floria, Mariana
Gavril, Oana Irina
Bărboi, Oana-Bogdana
Trifan, Anca
Cijevschi Prelipcean, Cristina
Mihai, Cătălina
Gavrilescu, Otilia
author_facet Dranga, Mihaela
Boiculese, Lucian Vasile
Popa, Iolanda Valentina
Floria, Mariana
Gavril, Oana Irina
Bărboi, Oana-Bogdana
Trifan, Anca
Cijevschi Prelipcean, Cristina
Mihai, Cătălina
Gavrilescu, Otilia
author_sort Dranga, Mihaela
collection PubMed
description Background and Objectives: Anemia is the most frequent complication of inflammatory bowel diseases. Clinically, anemia can affect important quality-of-life (QoL) components, such as exercise capacity, cognitive function, and the ability to carry out social activities. The disease activity has a significant impact on QoL, mainly due to clinical manifestations, which are more severe during the periods of disease activity. Our aim was to estimate the impact of anemia on QoL in patients with Crohn’s disease. Material and Methods. We made a prospective study on 134 patients with Crohn’s disease (CD) in a Romanian tertiary center. The CD diagnosis was established by colonoscopy and histopathological examination. In particular cases, additional examinations were required (small bowel capsule endoscopy, computed tomography enterography, and magnetic resonance enterography). Anemia was defined according to the World Health Organization’s definition, the activity of the disease was assessed by Crohn’s disease activity index (CDAI) score, and the QoL was evaluated by Inflammatory Bowel Disease Questionnaire 32 (IBDQ 32). Results: 44.8% patient had anemia, statistically related to the activity of the disease and corticoids use. We found a strong association between QoL and disease activity on all four sub-scores: patients with more severe activity had a significantly lower IBDQ (260.38 ± 116.96 vs. 163.85 ± 87.20, p = 0.001) and the presence of anemia (127.03 vs. 148.38, p = 0.001). In multiple regression analyses, both disease activity and anemia had an impact on the QoL. Conclusions: Anemia has high prevalence in the CD in northeastern region of Romania. Anemia was more common in female patients, in patients undergoing corticosteroid treatment, and in those with active disease. Both anemia and disease activity had a strong negative and independent impact on QoL.
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spelling pubmed-85391932021-10-24 Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease Dranga, Mihaela Boiculese, Lucian Vasile Popa, Iolanda Valentina Floria, Mariana Gavril, Oana Irina Bărboi, Oana-Bogdana Trifan, Anca Cijevschi Prelipcean, Cristina Mihai, Cătălina Gavrilescu, Otilia Medicina (Kaunas) Article Background and Objectives: Anemia is the most frequent complication of inflammatory bowel diseases. Clinically, anemia can affect important quality-of-life (QoL) components, such as exercise capacity, cognitive function, and the ability to carry out social activities. The disease activity has a significant impact on QoL, mainly due to clinical manifestations, which are more severe during the periods of disease activity. Our aim was to estimate the impact of anemia on QoL in patients with Crohn’s disease. Material and Methods. We made a prospective study on 134 patients with Crohn’s disease (CD) in a Romanian tertiary center. The CD diagnosis was established by colonoscopy and histopathological examination. In particular cases, additional examinations were required (small bowel capsule endoscopy, computed tomography enterography, and magnetic resonance enterography). Anemia was defined according to the World Health Organization’s definition, the activity of the disease was assessed by Crohn’s disease activity index (CDAI) score, and the QoL was evaluated by Inflammatory Bowel Disease Questionnaire 32 (IBDQ 32). Results: 44.8% patient had anemia, statistically related to the activity of the disease and corticoids use. We found a strong association between QoL and disease activity on all four sub-scores: patients with more severe activity had a significantly lower IBDQ (260.38 ± 116.96 vs. 163.85 ± 87.20, p = 0.001) and the presence of anemia (127.03 vs. 148.38, p = 0.001). In multiple regression analyses, both disease activity and anemia had an impact on the QoL. Conclusions: Anemia has high prevalence in the CD in northeastern region of Romania. Anemia was more common in female patients, in patients undergoing corticosteroid treatment, and in those with active disease. Both anemia and disease activity had a strong negative and independent impact on QoL. MDPI 2021-09-30 /pmc/articles/PMC8539193/ /pubmed/34684083 http://dx.doi.org/10.3390/medicina57101046 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dranga, Mihaela
Boiculese, Lucian Vasile
Popa, Iolanda Valentina
Floria, Mariana
Gavril, Oana Irina
Bărboi, Oana-Bogdana
Trifan, Anca
Cijevschi Prelipcean, Cristina
Mihai, Cătălina
Gavrilescu, Otilia
Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease
title Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease
title_full Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease
title_fullStr Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease
title_full_unstemmed Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease
title_short Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease
title_sort anemia in crohn’s disease—the unseen face of inflammatory bowel disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539193/
https://www.ncbi.nlm.nih.gov/pubmed/34684083
http://dx.doi.org/10.3390/medicina57101046
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