Acute Toxicity, Immunotoxicity and Allergenicity of Protease Complex Obtained from Micromycete Sarocladium strictum

The different effects on animals of the thrombolytic protease complex of the new producer S. strictum 203 were studied. The tests of acute toxicity, immunotoxicity and allergenicity should conclude that the studied proteolytic complex is safe for medical usage. For the intravenous and the intraperit...

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Autores principales: Alipkina, Svetlana, Kornienko, Elena, Nalobin, Denis, Osmolovskiy, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539265/
https://www.ncbi.nlm.nih.gov/pubmed/34683953
http://dx.doi.org/10.3390/pharmaceutics13101660
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author Alipkina, Svetlana
Kornienko, Elena
Nalobin, Denis
Osmolovskiy, Alexander
author_facet Alipkina, Svetlana
Kornienko, Elena
Nalobin, Denis
Osmolovskiy, Alexander
author_sort Alipkina, Svetlana
collection PubMed
description The different effects on animals of the thrombolytic protease complex of the new producer S. strictum 203 were studied. The tests of acute toxicity, immunotoxicity and allergenicity should conclude that the studied proteolytic complex is safe for medical usage. For the intravenous and the intraperitoneal routes of administration, the maximum tolerated dose and the median lethal dose were not determined.
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spelling pubmed-85392652021-10-24 Acute Toxicity, Immunotoxicity and Allergenicity of Protease Complex Obtained from Micromycete Sarocladium strictum Alipkina, Svetlana Kornienko, Elena Nalobin, Denis Osmolovskiy, Alexander Pharmaceutics Article The different effects on animals of the thrombolytic protease complex of the new producer S. strictum 203 were studied. The tests of acute toxicity, immunotoxicity and allergenicity should conclude that the studied proteolytic complex is safe for medical usage. For the intravenous and the intraperitoneal routes of administration, the maximum tolerated dose and the median lethal dose were not determined. MDPI 2021-10-11 /pmc/articles/PMC8539265/ /pubmed/34683953 http://dx.doi.org/10.3390/pharmaceutics13101660 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alipkina, Svetlana
Kornienko, Elena
Nalobin, Denis
Osmolovskiy, Alexander
Acute Toxicity, Immunotoxicity and Allergenicity of Protease Complex Obtained from Micromycete Sarocladium strictum
title Acute Toxicity, Immunotoxicity and Allergenicity of Protease Complex Obtained from Micromycete Sarocladium strictum
title_full Acute Toxicity, Immunotoxicity and Allergenicity of Protease Complex Obtained from Micromycete Sarocladium strictum
title_fullStr Acute Toxicity, Immunotoxicity and Allergenicity of Protease Complex Obtained from Micromycete Sarocladium strictum
title_full_unstemmed Acute Toxicity, Immunotoxicity and Allergenicity of Protease Complex Obtained from Micromycete Sarocladium strictum
title_short Acute Toxicity, Immunotoxicity and Allergenicity of Protease Complex Obtained from Micromycete Sarocladium strictum
title_sort acute toxicity, immunotoxicity and allergenicity of protease complex obtained from micromycete sarocladium strictum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539265/
https://www.ncbi.nlm.nih.gov/pubmed/34683953
http://dx.doi.org/10.3390/pharmaceutics13101660
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AT nalobindenis acutetoxicityimmunotoxicityandallergenicityofproteasecomplexobtainedfrommicromycetesarocladiumstrictum
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