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The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study
Vascular calcification and fragility fractures are associated with high morbidity and mortality, especially in end-stage renal disease. We evaluated the relationship of iliac arteries calcifications (IACs) and abdominal aortic calcifications (AACs) with the risk for vertebral fractures (VFs) in hemo...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539275/ https://www.ncbi.nlm.nih.gov/pubmed/34684568 http://dx.doi.org/10.3390/nu13103567 |
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author | Fusaro, Maria Tripepi, Giovanni Plebani, Mario Politi, Cristina Aghi, Andrea Taddei, Fulvia Schileo, Enrico Zaninotto, Martina La Manna, Gaetano Cianciolo, Giuseppe Gallieni, Maurizio Cosmai, Laura Messa, Piergiorgio Ravera, Maura Nickolas, Thomas L. Ferrari, Serge Ketteler, Markus Iervasi, Giorgio Mereu, Maria Cristina Vettor, Roberto Giannini, Sandro Gasperoni, Lorenzo Sella, Stefania Brandi, Maria Luisa Cianferotti, Luisella De Caterina, Raffaele |
author_facet | Fusaro, Maria Tripepi, Giovanni Plebani, Mario Politi, Cristina Aghi, Andrea Taddei, Fulvia Schileo, Enrico Zaninotto, Martina La Manna, Gaetano Cianciolo, Giuseppe Gallieni, Maurizio Cosmai, Laura Messa, Piergiorgio Ravera, Maura Nickolas, Thomas L. Ferrari, Serge Ketteler, Markus Iervasi, Giorgio Mereu, Maria Cristina Vettor, Roberto Giannini, Sandro Gasperoni, Lorenzo Sella, Stefania Brandi, Maria Luisa Cianferotti, Luisella De Caterina, Raffaele |
author_sort | Fusaro, Maria |
collection | PubMed |
description | Vascular calcification and fragility fractures are associated with high morbidity and mortality, especially in end-stage renal disease. We evaluated the relationship of iliac arteries calcifications (IACs) and abdominal aortic calcifications (AACs) with the risk for vertebral fractures (VFs) in hemodialysis patients. The VIKI study was a multicenter cross-sectional study involving 387 hemodialysis patients. The biochemical data included bone health markers, such as vitamin K levels, vitamin K-dependent proteins, vitamin 25(OH)D, alkaline phosphatase, parathormone, calcium, and phosphate. VF, IACs and AACs was determined through standardized spine radiograms. VF was defined as >20% reduction of vertebral body height, and VC were quantified by measuring the length of calcium deposits along the arteries. The prevalence of IACs and AACs were 56.1% and 80.6%, respectively. After adjusting for confounding variables, the presence of IACs was associated with 73% higher odds of VF (p = 0.028), whereas we found no association (p = 0.294) for AACs. IACs were associated with VF irrespective of calcification severity. Patients with IACs had lower levels of vitamin K2 and menaquinone 7 (0.99 vs. 1.15 ng/mL; p = 0.003), and this deficiency became greater with adjustment for triglycerides (0.57 vs. 0.87 ng/mL; p < 0.001). IACs, regardless of their extent, are a clinically relevant risk factor for VFs. The association is enhanced by adjusting for vitamin K, a main player in bone and vascular health. To our knowledge these results are the first in the literature. Prospective studies are needed to confirm these findings both in chronic kidney disease and in the general population. |
format | Online Article Text |
id | pubmed-8539275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85392752021-10-24 The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study Fusaro, Maria Tripepi, Giovanni Plebani, Mario Politi, Cristina Aghi, Andrea Taddei, Fulvia Schileo, Enrico Zaninotto, Martina La Manna, Gaetano Cianciolo, Giuseppe Gallieni, Maurizio Cosmai, Laura Messa, Piergiorgio Ravera, Maura Nickolas, Thomas L. Ferrari, Serge Ketteler, Markus Iervasi, Giorgio Mereu, Maria Cristina Vettor, Roberto Giannini, Sandro Gasperoni, Lorenzo Sella, Stefania Brandi, Maria Luisa Cianferotti, Luisella De Caterina, Raffaele Nutrients Article Vascular calcification and fragility fractures are associated with high morbidity and mortality, especially in end-stage renal disease. We evaluated the relationship of iliac arteries calcifications (IACs) and abdominal aortic calcifications (AACs) with the risk for vertebral fractures (VFs) in hemodialysis patients. The VIKI study was a multicenter cross-sectional study involving 387 hemodialysis patients. The biochemical data included bone health markers, such as vitamin K levels, vitamin K-dependent proteins, vitamin 25(OH)D, alkaline phosphatase, parathormone, calcium, and phosphate. VF, IACs and AACs was determined through standardized spine radiograms. VF was defined as >20% reduction of vertebral body height, and VC were quantified by measuring the length of calcium deposits along the arteries. The prevalence of IACs and AACs were 56.1% and 80.6%, respectively. After adjusting for confounding variables, the presence of IACs was associated with 73% higher odds of VF (p = 0.028), whereas we found no association (p = 0.294) for AACs. IACs were associated with VF irrespective of calcification severity. Patients with IACs had lower levels of vitamin K2 and menaquinone 7 (0.99 vs. 1.15 ng/mL; p = 0.003), and this deficiency became greater with adjustment for triglycerides (0.57 vs. 0.87 ng/mL; p < 0.001). IACs, regardless of their extent, are a clinically relevant risk factor for VFs. The association is enhanced by adjusting for vitamin K, a main player in bone and vascular health. To our knowledge these results are the first in the literature. Prospective studies are needed to confirm these findings both in chronic kidney disease and in the general population. MDPI 2021-10-12 /pmc/articles/PMC8539275/ /pubmed/34684568 http://dx.doi.org/10.3390/nu13103567 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fusaro, Maria Tripepi, Giovanni Plebani, Mario Politi, Cristina Aghi, Andrea Taddei, Fulvia Schileo, Enrico Zaninotto, Martina La Manna, Gaetano Cianciolo, Giuseppe Gallieni, Maurizio Cosmai, Laura Messa, Piergiorgio Ravera, Maura Nickolas, Thomas L. Ferrari, Serge Ketteler, Markus Iervasi, Giorgio Mereu, Maria Cristina Vettor, Roberto Giannini, Sandro Gasperoni, Lorenzo Sella, Stefania Brandi, Maria Luisa Cianferotti, Luisella De Caterina, Raffaele The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study |
title | The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study |
title_full | The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study |
title_fullStr | The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study |
title_full_unstemmed | The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study |
title_short | The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study |
title_sort | vessels-bone axis: iliac artery calcifications, vertebral fractures and vitamin k from viki study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539275/ https://www.ncbi.nlm.nih.gov/pubmed/34684568 http://dx.doi.org/10.3390/nu13103567 |
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