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The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study

Vascular calcification and fragility fractures are associated with high morbidity and mortality, especially in end-stage renal disease. We evaluated the relationship of iliac arteries calcifications (IACs) and abdominal aortic calcifications (AACs) with the risk for vertebral fractures (VFs) in hemo...

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Autores principales: Fusaro, Maria, Tripepi, Giovanni, Plebani, Mario, Politi, Cristina, Aghi, Andrea, Taddei, Fulvia, Schileo, Enrico, Zaninotto, Martina, La Manna, Gaetano, Cianciolo, Giuseppe, Gallieni, Maurizio, Cosmai, Laura, Messa, Piergiorgio, Ravera, Maura, Nickolas, Thomas L., Ferrari, Serge, Ketteler, Markus, Iervasi, Giorgio, Mereu, Maria Cristina, Vettor, Roberto, Giannini, Sandro, Gasperoni, Lorenzo, Sella, Stefania, Brandi, Maria Luisa, Cianferotti, Luisella, De Caterina, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539275/
https://www.ncbi.nlm.nih.gov/pubmed/34684568
http://dx.doi.org/10.3390/nu13103567
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author Fusaro, Maria
Tripepi, Giovanni
Plebani, Mario
Politi, Cristina
Aghi, Andrea
Taddei, Fulvia
Schileo, Enrico
Zaninotto, Martina
La Manna, Gaetano
Cianciolo, Giuseppe
Gallieni, Maurizio
Cosmai, Laura
Messa, Piergiorgio
Ravera, Maura
Nickolas, Thomas L.
Ferrari, Serge
Ketteler, Markus
Iervasi, Giorgio
Mereu, Maria Cristina
Vettor, Roberto
Giannini, Sandro
Gasperoni, Lorenzo
Sella, Stefania
Brandi, Maria Luisa
Cianferotti, Luisella
De Caterina, Raffaele
author_facet Fusaro, Maria
Tripepi, Giovanni
Plebani, Mario
Politi, Cristina
Aghi, Andrea
Taddei, Fulvia
Schileo, Enrico
Zaninotto, Martina
La Manna, Gaetano
Cianciolo, Giuseppe
Gallieni, Maurizio
Cosmai, Laura
Messa, Piergiorgio
Ravera, Maura
Nickolas, Thomas L.
Ferrari, Serge
Ketteler, Markus
Iervasi, Giorgio
Mereu, Maria Cristina
Vettor, Roberto
Giannini, Sandro
Gasperoni, Lorenzo
Sella, Stefania
Brandi, Maria Luisa
Cianferotti, Luisella
De Caterina, Raffaele
author_sort Fusaro, Maria
collection PubMed
description Vascular calcification and fragility fractures are associated with high morbidity and mortality, especially in end-stage renal disease. We evaluated the relationship of iliac arteries calcifications (IACs) and abdominal aortic calcifications (AACs) with the risk for vertebral fractures (VFs) in hemodialysis patients. The VIKI study was a multicenter cross-sectional study involving 387 hemodialysis patients. The biochemical data included bone health markers, such as vitamin K levels, vitamin K-dependent proteins, vitamin 25(OH)D, alkaline phosphatase, parathormone, calcium, and phosphate. VF, IACs and AACs was determined through standardized spine radiograms. VF was defined as >20% reduction of vertebral body height, and VC were quantified by measuring the length of calcium deposits along the arteries. The prevalence of IACs and AACs were 56.1% and 80.6%, respectively. After adjusting for confounding variables, the presence of IACs was associated with 73% higher odds of VF (p = 0.028), whereas we found no association (p = 0.294) for AACs. IACs were associated with VF irrespective of calcification severity. Patients with IACs had lower levels of vitamin K2 and menaquinone 7 (0.99 vs. 1.15 ng/mL; p = 0.003), and this deficiency became greater with adjustment for triglycerides (0.57 vs. 0.87 ng/mL; p < 0.001). IACs, regardless of their extent, are a clinically relevant risk factor for VFs. The association is enhanced by adjusting for vitamin K, a main player in bone and vascular health. To our knowledge these results are the first in the literature. Prospective studies are needed to confirm these findings both in chronic kidney disease and in the general population.
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spelling pubmed-85392752021-10-24 The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study Fusaro, Maria Tripepi, Giovanni Plebani, Mario Politi, Cristina Aghi, Andrea Taddei, Fulvia Schileo, Enrico Zaninotto, Martina La Manna, Gaetano Cianciolo, Giuseppe Gallieni, Maurizio Cosmai, Laura Messa, Piergiorgio Ravera, Maura Nickolas, Thomas L. Ferrari, Serge Ketteler, Markus Iervasi, Giorgio Mereu, Maria Cristina Vettor, Roberto Giannini, Sandro Gasperoni, Lorenzo Sella, Stefania Brandi, Maria Luisa Cianferotti, Luisella De Caterina, Raffaele Nutrients Article Vascular calcification and fragility fractures are associated with high morbidity and mortality, especially in end-stage renal disease. We evaluated the relationship of iliac arteries calcifications (IACs) and abdominal aortic calcifications (AACs) with the risk for vertebral fractures (VFs) in hemodialysis patients. The VIKI study was a multicenter cross-sectional study involving 387 hemodialysis patients. The biochemical data included bone health markers, such as vitamin K levels, vitamin K-dependent proteins, vitamin 25(OH)D, alkaline phosphatase, parathormone, calcium, and phosphate. VF, IACs and AACs was determined through standardized spine radiograms. VF was defined as >20% reduction of vertebral body height, and VC were quantified by measuring the length of calcium deposits along the arteries. The prevalence of IACs and AACs were 56.1% and 80.6%, respectively. After adjusting for confounding variables, the presence of IACs was associated with 73% higher odds of VF (p = 0.028), whereas we found no association (p = 0.294) for AACs. IACs were associated with VF irrespective of calcification severity. Patients with IACs had lower levels of vitamin K2 and menaquinone 7 (0.99 vs. 1.15 ng/mL; p = 0.003), and this deficiency became greater with adjustment for triglycerides (0.57 vs. 0.87 ng/mL; p < 0.001). IACs, regardless of their extent, are a clinically relevant risk factor for VFs. The association is enhanced by adjusting for vitamin K, a main player in bone and vascular health. To our knowledge these results are the first in the literature. Prospective studies are needed to confirm these findings both in chronic kidney disease and in the general population. MDPI 2021-10-12 /pmc/articles/PMC8539275/ /pubmed/34684568 http://dx.doi.org/10.3390/nu13103567 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fusaro, Maria
Tripepi, Giovanni
Plebani, Mario
Politi, Cristina
Aghi, Andrea
Taddei, Fulvia
Schileo, Enrico
Zaninotto, Martina
La Manna, Gaetano
Cianciolo, Giuseppe
Gallieni, Maurizio
Cosmai, Laura
Messa, Piergiorgio
Ravera, Maura
Nickolas, Thomas L.
Ferrari, Serge
Ketteler, Markus
Iervasi, Giorgio
Mereu, Maria Cristina
Vettor, Roberto
Giannini, Sandro
Gasperoni, Lorenzo
Sella, Stefania
Brandi, Maria Luisa
Cianferotti, Luisella
De Caterina, Raffaele
The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study
title The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study
title_full The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study
title_fullStr The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study
title_full_unstemmed The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study
title_short The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study
title_sort vessels-bone axis: iliac artery calcifications, vertebral fractures and vitamin k from viki study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539275/
https://www.ncbi.nlm.nih.gov/pubmed/34684568
http://dx.doi.org/10.3390/nu13103567
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