Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology

The synthesis of photoswitchable azo-dibenzo[b,f]oxepine derivatives and microtubule inhibitors were described. Subsequently, we examined the reaction of methoxy derivative 3-nitrodibenzo[b,f]oxepine with different aldehydes and in the presence of BF(3)·OEt(2) as a catalyst. Our study provided a ver...

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Detalles Bibliográficos
Autores principales: Tobiasz, Piotr, Borys, Filip, Borecka, Marta, Krawczyk, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539288/
https://www.ncbi.nlm.nih.gov/pubmed/34681697
http://dx.doi.org/10.3390/ijms222011033
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author Tobiasz, Piotr
Borys, Filip
Borecka, Marta
Krawczyk, Hanna
author_facet Tobiasz, Piotr
Borys, Filip
Borecka, Marta
Krawczyk, Hanna
author_sort Tobiasz, Piotr
collection PubMed
description The synthesis of photoswitchable azo-dibenzo[b,f]oxepine derivatives and microtubule inhibitors were described. Subsequently, we examined the reaction of methoxy derivative 3-nitrodibenzo[b,f]oxepine with different aldehydes and in the presence of BF(3)·OEt(2) as a catalyst. Our study provided a very concise method for the construction of the azo-dibenzo[b,f]oxepine skeleton. The analysis of products was run using experimental and theoretical methods. Next, we evaluated the E/Z isomerization of azo-dibenzo[b,f]oxepine derivatives, which could be photochemically controlled using visible-wavelength light.
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spelling pubmed-85392882021-10-24 Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology Tobiasz, Piotr Borys, Filip Borecka, Marta Krawczyk, Hanna Int J Mol Sci Communication The synthesis of photoswitchable azo-dibenzo[b,f]oxepine derivatives and microtubule inhibitors were described. Subsequently, we examined the reaction of methoxy derivative 3-nitrodibenzo[b,f]oxepine with different aldehydes and in the presence of BF(3)·OEt(2) as a catalyst. Our study provided a very concise method for the construction of the azo-dibenzo[b,f]oxepine skeleton. The analysis of products was run using experimental and theoretical methods. Next, we evaluated the E/Z isomerization of azo-dibenzo[b,f]oxepine derivatives, which could be photochemically controlled using visible-wavelength light. MDPI 2021-10-13 /pmc/articles/PMC8539288/ /pubmed/34681697 http://dx.doi.org/10.3390/ijms222011033 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Tobiasz, Piotr
Borys, Filip
Borecka, Marta
Krawczyk, Hanna
Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
title Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
title_full Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
title_fullStr Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
title_full_unstemmed Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
title_short Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
title_sort synthesis and investigations of building blocks with dibenzo[b,f] oxepine for use in photopharmacology
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539288/
https://www.ncbi.nlm.nih.gov/pubmed/34681697
http://dx.doi.org/10.3390/ijms222011033
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