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The Sirenic Links between Diabetes, Obesity, and Bladder Cancer
There is considerable evidence of a positive association between the incidence of type 2 diabetes mellitus (T2DM) and obesity with bladder cancer (BCa), with the link between T2DM and obesity having already been established. There also appear to be potential associations between Pleckstrin homology...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539374/ https://www.ncbi.nlm.nih.gov/pubmed/34681810 http://dx.doi.org/10.3390/ijms222011150 |
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author | Gill, Emily Sandhu, Gurimaan Ward, Douglas G. Perks, Claire M. Bryan, Richard T. |
author_facet | Gill, Emily Sandhu, Gurimaan Ward, Douglas G. Perks, Claire M. Bryan, Richard T. |
author_sort | Gill, Emily |
collection | PubMed |
description | There is considerable evidence of a positive association between the incidence of type 2 diabetes mellitus (T2DM) and obesity with bladder cancer (BCa), with the link between T2DM and obesity having already been established. There also appear to be potential associations between Pleckstrin homology domain containing S1 (PLEKHS1) and the Insulin-like Growth Factor (IGF) axis. Seven literature searches were carried out to investigate the backgrounds of these potential links. PLEKHS1 is a candidate biomarker in BCa, with mutations that are easily detectable in urine and increased expression seemingly associated with worse disease states. PLEKHS1 has also been implicated as a potential mediator for the onset of T2DM in people with obesity. The substantial evidence of the involvement of IGF in BCa, the role of the IGF axis in obesity and T2DM, and the global prevalence of T2DM and obesity suggest there is scope for investigating the links between these components. Preliminary findings on the relationship between PLEKHS1 and the IGF axis signal possible associations with BCa progression. This indicates that PLEKHS1 plays a role in the pathogenesis of BCa that may be mediated by members of the IGF axis. Further detailed research is needed to establish the relationship between PLEKHS1 and the IGF axis in BCa and determine how these phenomena overlap with T2DM and obesity. |
format | Online Article Text |
id | pubmed-8539374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85393742021-10-24 The Sirenic Links between Diabetes, Obesity, and Bladder Cancer Gill, Emily Sandhu, Gurimaan Ward, Douglas G. Perks, Claire M. Bryan, Richard T. Int J Mol Sci Review There is considerable evidence of a positive association between the incidence of type 2 diabetes mellitus (T2DM) and obesity with bladder cancer (BCa), with the link between T2DM and obesity having already been established. There also appear to be potential associations between Pleckstrin homology domain containing S1 (PLEKHS1) and the Insulin-like Growth Factor (IGF) axis. Seven literature searches were carried out to investigate the backgrounds of these potential links. PLEKHS1 is a candidate biomarker in BCa, with mutations that are easily detectable in urine and increased expression seemingly associated with worse disease states. PLEKHS1 has also been implicated as a potential mediator for the onset of T2DM in people with obesity. The substantial evidence of the involvement of IGF in BCa, the role of the IGF axis in obesity and T2DM, and the global prevalence of T2DM and obesity suggest there is scope for investigating the links between these components. Preliminary findings on the relationship between PLEKHS1 and the IGF axis signal possible associations with BCa progression. This indicates that PLEKHS1 plays a role in the pathogenesis of BCa that may be mediated by members of the IGF axis. Further detailed research is needed to establish the relationship between PLEKHS1 and the IGF axis in BCa and determine how these phenomena overlap with T2DM and obesity. MDPI 2021-10-15 /pmc/articles/PMC8539374/ /pubmed/34681810 http://dx.doi.org/10.3390/ijms222011150 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gill, Emily Sandhu, Gurimaan Ward, Douglas G. Perks, Claire M. Bryan, Richard T. The Sirenic Links between Diabetes, Obesity, and Bladder Cancer |
title | The Sirenic Links between Diabetes, Obesity, and Bladder Cancer |
title_full | The Sirenic Links between Diabetes, Obesity, and Bladder Cancer |
title_fullStr | The Sirenic Links between Diabetes, Obesity, and Bladder Cancer |
title_full_unstemmed | The Sirenic Links between Diabetes, Obesity, and Bladder Cancer |
title_short | The Sirenic Links between Diabetes, Obesity, and Bladder Cancer |
title_sort | sirenic links between diabetes, obesity, and bladder cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539374/ https://www.ncbi.nlm.nih.gov/pubmed/34681810 http://dx.doi.org/10.3390/ijms222011150 |
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