Cargando…
Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature
This article collects several published cases in which immune thrombocytopenic purpura (ITP) is followed by essential thrombocythemia (ET) and vice versa. This surprising clinical condition is possible, but very rare and difficult to diagnose and manage. We have made an attempt to analyse the possib...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539407/ https://www.ncbi.nlm.nih.gov/pubmed/34681577 http://dx.doi.org/10.3390/ijms222010918 |
_version_ | 1784588739562962944 |
---|---|
author | Sobas, Marta Podolak-Dawidziak, Maria Lewandowski, Krzysztof Bator, Michał Wróbel, Tomasz |
author_facet | Sobas, Marta Podolak-Dawidziak, Maria Lewandowski, Krzysztof Bator, Michał Wróbel, Tomasz |
author_sort | Sobas, Marta |
collection | PubMed |
description | This article collects several published cases in which immune thrombocytopenic purpura (ITP) is followed by essential thrombocythemia (ET) and vice versa. This surprising clinical condition is possible, but very rare and difficult to diagnose and manage. We have made an attempt to analyse the possible causes of the sequential appearance of ITP and ET taking into consideration the following: alteration of the thrombopoietin (TPO) receptor, the role of autoimmunity and inflammation, and cytokine modulation. A better understanding of these interactions may provide opportunities to determine predisposing factors and aid in finding new treatment modalities both for ITP and ET patients. |
format | Online Article Text |
id | pubmed-8539407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85394072021-10-24 Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature Sobas, Marta Podolak-Dawidziak, Maria Lewandowski, Krzysztof Bator, Michał Wróbel, Tomasz Int J Mol Sci Review This article collects several published cases in which immune thrombocytopenic purpura (ITP) is followed by essential thrombocythemia (ET) and vice versa. This surprising clinical condition is possible, but very rare and difficult to diagnose and manage. We have made an attempt to analyse the possible causes of the sequential appearance of ITP and ET taking into consideration the following: alteration of the thrombopoietin (TPO) receptor, the role of autoimmunity and inflammation, and cytokine modulation. A better understanding of these interactions may provide opportunities to determine predisposing factors and aid in finding new treatment modalities both for ITP and ET patients. MDPI 2021-10-09 /pmc/articles/PMC8539407/ /pubmed/34681577 http://dx.doi.org/10.3390/ijms222010918 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sobas, Marta Podolak-Dawidziak, Maria Lewandowski, Krzysztof Bator, Michał Wróbel, Tomasz Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature |
title | Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature |
title_full | Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature |
title_fullStr | Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature |
title_full_unstemmed | Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature |
title_short | Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature |
title_sort | primary immune thrombocytopenia and essential thrombocythemia: so different and yet somehow similar—cases series and a review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539407/ https://www.ncbi.nlm.nih.gov/pubmed/34681577 http://dx.doi.org/10.3390/ijms222010918 |
work_keys_str_mv | AT sobasmarta primaryimmunethrombocytopeniaandessentialthrombocythemiasodifferentandyetsomehowsimilarcasesseriesandareviewoftheliterature AT podolakdawidziakmaria primaryimmunethrombocytopeniaandessentialthrombocythemiasodifferentandyetsomehowsimilarcasesseriesandareviewoftheliterature AT lewandowskikrzysztof primaryimmunethrombocytopeniaandessentialthrombocythemiasodifferentandyetsomehowsimilarcasesseriesandareviewoftheliterature AT batormichał primaryimmunethrombocytopeniaandessentialthrombocythemiasodifferentandyetsomehowsimilarcasesseriesandareviewoftheliterature AT wrobeltomasz primaryimmunethrombocytopeniaandessentialthrombocythemiasodifferentandyetsomehowsimilarcasesseriesandareviewoftheliterature |