Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane

Botulinum neurotoxin serotype A (BoNT/A) is the most potent protein toxin to humans. BoNT/A light chain (LC/A) cleavage of the membrane-bound SNAP-25 has been well-characterized, but how LC/A traffics to the plasma membrane to target SNAP-25 is unknown. Of the eight BoNT/A subtypes (A1–A8), LC/A3 ha...

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Detalles Bibliográficos
Autores principales: Gardner, Alexander, Tepp, William H., Bradshaw, Marite, Barbieri, Joseph T., Pellett, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539409/
https://www.ncbi.nlm.nih.gov/pubmed/34681775
http://dx.doi.org/10.3390/ijms222011115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539409/
https://www.ncbi.nlm.nih.gov/pubmed/34681775
http://dx.doi.org/10.3390/ijms222011115

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