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Diabetic Wound-Healing Science
Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539411/ https://www.ncbi.nlm.nih.gov/pubmed/34684109 http://dx.doi.org/10.3390/medicina57101072 |
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author | Burgess, Jamie L. Wyant, W. Austin Abdo Abujamra, Beatriz Kirsner, Robert S. Jozic, Ivan |
author_facet | Burgess, Jamie L. Wyant, W. Austin Abdo Abujamra, Beatriz Kirsner, Robert S. Jozic, Ivan |
author_sort | Burgess, Jamie L. |
collection | PubMed |
description | Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in lower limb amputation, with subsequent high economic and psychosocial costs. The hyperglycemic environment promotes the formation of biofilms and makes diabetic wounds difficult to treat. In this review, we present updates regarding recent advances in our understanding of the pathophysiology of diabetic wounds focusing on impaired angiogenesis, neuropathy, sub-optimal chronic inflammatory response, barrier disruption, and subsequent polymicrobial infection, followed by current and future treatment strategies designed to tackle the various pathologies associated with diabetic wounds. Given the alarming increase in the prevalence of diabetes, and subsequently diabetic wounds, it is imperative that future treatment strategies target multiple causes of impaired healing in diabetic wounds. |
format | Online Article Text |
id | pubmed-8539411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85394112021-10-24 Diabetic Wound-Healing Science Burgess, Jamie L. Wyant, W. Austin Abdo Abujamra, Beatriz Kirsner, Robert S. Jozic, Ivan Medicina (Kaunas) Review Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in lower limb amputation, with subsequent high economic and psychosocial costs. The hyperglycemic environment promotes the formation of biofilms and makes diabetic wounds difficult to treat. In this review, we present updates regarding recent advances in our understanding of the pathophysiology of diabetic wounds focusing on impaired angiogenesis, neuropathy, sub-optimal chronic inflammatory response, barrier disruption, and subsequent polymicrobial infection, followed by current and future treatment strategies designed to tackle the various pathologies associated with diabetic wounds. Given the alarming increase in the prevalence of diabetes, and subsequently diabetic wounds, it is imperative that future treatment strategies target multiple causes of impaired healing in diabetic wounds. MDPI 2021-10-08 /pmc/articles/PMC8539411/ /pubmed/34684109 http://dx.doi.org/10.3390/medicina57101072 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Burgess, Jamie L. Wyant, W. Austin Abdo Abujamra, Beatriz Kirsner, Robert S. Jozic, Ivan Diabetic Wound-Healing Science |
title | Diabetic Wound-Healing Science |
title_full | Diabetic Wound-Healing Science |
title_fullStr | Diabetic Wound-Healing Science |
title_full_unstemmed | Diabetic Wound-Healing Science |
title_short | Diabetic Wound-Healing Science |
title_sort | diabetic wound-healing science |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539411/ https://www.ncbi.nlm.nih.gov/pubmed/34684109 http://dx.doi.org/10.3390/medicina57101072 |
work_keys_str_mv | AT burgessjamiel diabeticwoundhealingscience AT wyantwaustin diabeticwoundhealingscience AT abdoabujamrabeatriz diabeticwoundhealingscience AT kirsnerroberts diabeticwoundhealingscience AT jozicivan diabeticwoundhealingscience |