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Diabetic Wound-Healing Science

Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in...

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Detalles Bibliográficos
Autores principales: Burgess, Jamie L., Wyant, W. Austin, Abdo Abujamra, Beatriz, Kirsner, Robert S., Jozic, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539411/
https://www.ncbi.nlm.nih.gov/pubmed/34684109
http://dx.doi.org/10.3390/medicina57101072
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author Burgess, Jamie L.
Wyant, W. Austin
Abdo Abujamra, Beatriz
Kirsner, Robert S.
Jozic, Ivan
author_facet Burgess, Jamie L.
Wyant, W. Austin
Abdo Abujamra, Beatriz
Kirsner, Robert S.
Jozic, Ivan
author_sort Burgess, Jamie L.
collection PubMed
description Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in lower limb amputation, with subsequent high economic and psychosocial costs. The hyperglycemic environment promotes the formation of biofilms and makes diabetic wounds difficult to treat. In this review, we present updates regarding recent advances in our understanding of the pathophysiology of diabetic wounds focusing on impaired angiogenesis, neuropathy, sub-optimal chronic inflammatory response, barrier disruption, and subsequent polymicrobial infection, followed by current and future treatment strategies designed to tackle the various pathologies associated with diabetic wounds. Given the alarming increase in the prevalence of diabetes, and subsequently diabetic wounds, it is imperative that future treatment strategies target multiple causes of impaired healing in diabetic wounds.
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spelling pubmed-85394112021-10-24 Diabetic Wound-Healing Science Burgess, Jamie L. Wyant, W. Austin Abdo Abujamra, Beatriz Kirsner, Robert S. Jozic, Ivan Medicina (Kaunas) Review Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in lower limb amputation, with subsequent high economic and psychosocial costs. The hyperglycemic environment promotes the formation of biofilms and makes diabetic wounds difficult to treat. In this review, we present updates regarding recent advances in our understanding of the pathophysiology of diabetic wounds focusing on impaired angiogenesis, neuropathy, sub-optimal chronic inflammatory response, barrier disruption, and subsequent polymicrobial infection, followed by current and future treatment strategies designed to tackle the various pathologies associated with diabetic wounds. Given the alarming increase in the prevalence of diabetes, and subsequently diabetic wounds, it is imperative that future treatment strategies target multiple causes of impaired healing in diabetic wounds. MDPI 2021-10-08 /pmc/articles/PMC8539411/ /pubmed/34684109 http://dx.doi.org/10.3390/medicina57101072 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Burgess, Jamie L.
Wyant, W. Austin
Abdo Abujamra, Beatriz
Kirsner, Robert S.
Jozic, Ivan
Diabetic Wound-Healing Science
title Diabetic Wound-Healing Science
title_full Diabetic Wound-Healing Science
title_fullStr Diabetic Wound-Healing Science
title_full_unstemmed Diabetic Wound-Healing Science
title_short Diabetic Wound-Healing Science
title_sort diabetic wound-healing science
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539411/
https://www.ncbi.nlm.nih.gov/pubmed/34684109
http://dx.doi.org/10.3390/medicina57101072
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