Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia

Standard of care therapies for children with acute myeloid leukemia (AML) cause potent off-target toxicity to healthy cells, highlighting the need to develop new therapeutic approaches that are safe and specific for leukemia cells. Long non-coding RNAs (lncRNAs) are an emerging and highly attractive...

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Detalles Bibliográficos
Autores principales: Connerty, Patrick, Moles, Ernest, de Bock, Charles E., Jayatilleke, Nisitha, Smith, Jenny L., Meshinchi, Soheil, Mayoh, Chelsea, Kavallaris, Maria, Lock, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539450/
https://www.ncbi.nlm.nih.gov/pubmed/34683974
http://dx.doi.org/10.3390/pharmaceutics13101681

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