Cargando…

The Structure and Functions of PRMT5 in Human Diseases

Since the discovery of protein arginine methyltransferase 5 (PRMT5) and the resolution of its structure, an increasing number of papers have investigated and delineated the structural and functional role of PRMT5 in diseased conditions. PRMT5 is a type II arginine methyltransferase that catalyzes sy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Motolani, Aishat, Martin, Matthew, Sun, Mengyao, Lu, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539453/ https://www.ncbi.nlm.nih.gov/pubmed/34685445 http://dx.doi.org/10.3390/life11101074

Ejemplares similares

PRMT5 is a therapeutic target in choroidal neovascularization
por: Muniyandi, Anbukkarasi, et al.
Publicado: (2023)

The Pivotal Player: Components of NF-κB Pathway as Promising Biomarkers in Colorectal Cancer
por: Martin, Matthew, et al.
Publicado: (2021)

Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
por: Motolani, Aishat, et al.
Publicado: (2020)

A complex signature network that controls the upregulation of PRMT5 in colorectal cancer
por: Wei, Han, et al.
Publicado: (2021)

The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease
por: Sun, Emily, et al.
Publicado: (2022)

Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer
por: Hartley, Antja-Voy, et al.
Publicado: (2020)

PRMT5 function and targeting in cancer
por: Kim, Hyungsoo, et al.
Publicado: (2020)

Structure, Activity, and Function of PRMT1
por: Thiebaut, Charlène, et al.
Publicado: (2021)

Structure and Function of Protein Arginine Methyltransferase PRMT7
por: Halabelian, Levon, et al.
Publicado: (2021)

Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation
por: Dashti, Parisa, et al.
Publicado: (2023)

The Role of PRMT5 in Immuno-Oncology
por: Abe, Yoshinori, et al.
Publicado: (2023)

Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase
por: Cura, Vincent, et al.
Publicado: (2021)

PRMT5-mediated methylation of YBX1 regulates NF-κB activity in colorectal cancer
por: Hartley, Antja-Voy, et al.
Publicado: (2020)

PRMT1 loss sensitizes cells to PRMT5 inhibition
por: Gao, Guozhen, et al.
Publicado: (2019)

PRMT5: An Emerging Target for Pancreatic Adenocarcinoma
por: Lee, Michael K. C., et al.
Publicado: (2021)

Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer
por: Shailesh, Harshita, et al.
Publicado: (2018)

Critical Role of Novel O-GlcNAcylation of S550 and S551 on the p65 Subunit of NF-κB in Pancreatic Cancer
por: Motolani, Aishat, et al.
Publicado: (2023)

Cryo-electron microscopy structure of a human PRMT5:MEP50 complex
por: Timm, David E., et al.
Publicado: (2018)

The Methyltransferases PRMT4/CARM1 and PRMT5 Control Differentially Myogenesis in Zebrafish
por: Batut, Julie, et al.
Publicado: (2011)

The Role of the PRMT5–SND1 Axis in Hepatocellular Carcinoma
por: Wright, Tanner, et al.
Publicado: (2021)

PRMT5 inhibitors on the (myeloma) road
por: Gulla, Annamaria, et al.
Publicado: (2018)

PRMT5 prognostic value in cancer
por: Lattouf, Hanine, et al.
Publicado: (2019)

Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
por: Dong, Rui, et al.
Publicado: (2021)

PRMT5 links lipid metabolism to contractile function of skeletal muscles
por: Kim, Kun Ho, et al.
Publicado: (2023)

PRMT5-mediated regulation of developmental myelination
por: Scaglione, Antonella, et al.
Publicado: (2018)

PRMT5 in gene regulation and hematologic malignancies
por: Zhu, Fen, et al.
Publicado: (2019)

Antitumor Effects of PRMT5 Inhibition in Sarcomas
por: Verbeke, Stéphanie, et al.
Publicado: (2023)

PRMT5 Promotes EMT Through Regulating Akt Activity in Human Lung Cancer
por: Huang, Jianhao, et al.
Publicado: (2021)

The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR(L) in human lung cancer cells
por: Li, Mingyue, et al.
Publicado: (2019)

KDM2A Deficiency in the Liver Promotes Abnormal Liver Function and Potential Liver Damage
por: Martin, Matthew, et al.
Publicado: (2023)

The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4
por: Mallappa, Chandrashekara, et al.
Publicado: (2011)

Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors in Oncology Clinical Trials: A review
por: Feustel, Kavanya, et al.
Publicado: (2022)

PRMT5 inhibition disrupts splicing and stemness in glioblastoma
por: Sachamitr, Patty, et al.
Publicado: (2021)

Prmt5 differentiates developmental vs regenerative myogenesis
por: Zhang, Ting, et al.
Publicado: (2015)

PRMT5-dependent p53 escape in tumorigenesis
por: Li, Yan, et al.
Publicado: (2015)

Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2015)

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
por: Gunnell, Emma A., et al.
Publicado: (2020)

Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest
por: Li, Chao, et al.
Publicado: (2022)

Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome
por: Hernando, Carlos E, et al.
Publicado: (2015)

Protein Arginine Methyltransferase 5 (PRMT5) Mutations in Cancer Cells
por: Rasheed, Shayaan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dkuibp3rojbhmmpbv2i88n5dl9