Cargando…

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, and viruses. Because of the burgeoning growth of microbes with antimicrobial-resistant traits, there is...

Descripción completa

Detalles Bibliográficos
Autores principales: Srinivasan, Ramanathan, Kannappan, Arunachalam, Shi, Chunlei, Lin, Xiangmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539464/
https://www.ncbi.nlm.nih.gov/pubmed/34677431
http://dx.doi.org/10.3390/md19100530
_version_ 1784588753255268352
author Srinivasan, Ramanathan
Kannappan, Arunachalam
Shi, Chunlei
Lin, Xiangmin
author_facet Srinivasan, Ramanathan
Kannappan, Arunachalam
Shi, Chunlei
Lin, Xiangmin
author_sort Srinivasan, Ramanathan
collection PubMed
description The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, and viruses. Because of the burgeoning growth of microbes with antimicrobial-resistant traits, there is a dire need to identify and develop novel and effective antimicrobial agents to treat infections from antimicrobial-resistant strains. The marine environment is rich in ecological biodiversity and can be regarded as an untapped resource for prospecting novel bioactive compounds. Therefore, exploring the marine environment for antimicrobial agents plays a significant role in drug development and biomedical research. Several earlier scientific investigations have proven that bacterial diversity in the marine environment represents an emerging source of structurally unique and novel antimicrobial agents. There are several reports on marine bacterial secondary metabolites, and many are pharmacologically significant and have enormous promise for developing effective antimicrobial drugs to combat microbial infections in drug-resistant pathogens. In this review, we attempt to summarize published articles from the last twenty-five years (1996–2020) on antimicrobial secondary metabolites from marine bacteria evolved in marine environments, such as marine sediment, water, fauna, and flora.
format Online
Article
Text
id pubmed-8539464
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85394642021-10-24 Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds Srinivasan, Ramanathan Kannappan, Arunachalam Shi, Chunlei Lin, Xiangmin Mar Drugs Review The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, and viruses. Because of the burgeoning growth of microbes with antimicrobial-resistant traits, there is a dire need to identify and develop novel and effective antimicrobial agents to treat infections from antimicrobial-resistant strains. The marine environment is rich in ecological biodiversity and can be regarded as an untapped resource for prospecting novel bioactive compounds. Therefore, exploring the marine environment for antimicrobial agents plays a significant role in drug development and biomedical research. Several earlier scientific investigations have proven that bacterial diversity in the marine environment represents an emerging source of structurally unique and novel antimicrobial agents. There are several reports on marine bacterial secondary metabolites, and many are pharmacologically significant and have enormous promise for developing effective antimicrobial drugs to combat microbial infections in drug-resistant pathogens. In this review, we attempt to summarize published articles from the last twenty-five years (1996–2020) on antimicrobial secondary metabolites from marine bacteria evolved in marine environments, such as marine sediment, water, fauna, and flora. MDPI 2021-09-23 /pmc/articles/PMC8539464/ /pubmed/34677431 http://dx.doi.org/10.3390/md19100530 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Srinivasan, Ramanathan
Kannappan, Arunachalam
Shi, Chunlei
Lin, Xiangmin
Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds
title Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds
title_full Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds
title_fullStr Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds
title_full_unstemmed Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds
title_short Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds
title_sort marine bacterial secondary metabolites: a treasure house for structurally unique and effective antimicrobial compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539464/
https://www.ncbi.nlm.nih.gov/pubmed/34677431
http://dx.doi.org/10.3390/md19100530
work_keys_str_mv AT srinivasanramanathan marinebacterialsecondarymetabolitesatreasurehouseforstructurallyuniqueandeffectiveantimicrobialcompounds
AT kannappanarunachalam marinebacterialsecondarymetabolitesatreasurehouseforstructurallyuniqueandeffectiveantimicrobialcompounds
AT shichunlei marinebacterialsecondarymetabolitesatreasurehouseforstructurallyuniqueandeffectiveantimicrobialcompounds
AT linxiangmin marinebacterialsecondarymetabolitesatreasurehouseforstructurallyuniqueandeffectiveantimicrobialcompounds