Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination

The efficacy and safety of the BNT162b2 vaccine are known, but antibodies are expected to decrease over time after vaccination. We collected blood samples from 104 fully vaccinated health care workers at 3 and 5 weeks after first vaccination and 4 months after second vaccination. Antibody titers and...

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Autores principales: Jo, Dong-Ho, Minn, Dohsik, Lim, Jaegyun, Lee, Ki-Deok, Kang, Yu-Min, Choe, Kang-Won, Kim, Kwang-Nam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539465/
https://www.ncbi.nlm.nih.gov/pubmed/34696253
http://dx.doi.org/10.3390/vaccines9101145
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author Jo, Dong-Ho
Minn, Dohsik
Lim, Jaegyun
Lee, Ki-Deok
Kang, Yu-Min
Choe, Kang-Won
Kim, Kwang-Nam
author_facet Jo, Dong-Ho
Minn, Dohsik
Lim, Jaegyun
Lee, Ki-Deok
Kang, Yu-Min
Choe, Kang-Won
Kim, Kwang-Nam
author_sort Jo, Dong-Ho
collection PubMed
description The efficacy and safety of the BNT162b2 vaccine are known, but antibodies are expected to decrease over time after vaccination. We collected blood samples from 104 fully vaccinated health care workers at 3 and 5 weeks after first vaccination and 4 months after second vaccination. Antibody titers and neutralizing antibodies were measured. In our study, both antibody titers and neutralizing antibodies increased significantly at 5 weeks after first vaccination but decreased rapidly at 4 months after second vaccination. Additionally, the results showed a significant decrease regardless of gender or age. Further studies are needed to help determine the interval of SARS-CoV-2 vaccinations.
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spelling pubmed-85394652021-10-24 Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination Jo, Dong-Ho Minn, Dohsik Lim, Jaegyun Lee, Ki-Deok Kang, Yu-Min Choe, Kang-Won Kim, Kwang-Nam Vaccines (Basel) Brief Report The efficacy and safety of the BNT162b2 vaccine are known, but antibodies are expected to decrease over time after vaccination. We collected blood samples from 104 fully vaccinated health care workers at 3 and 5 weeks after first vaccination and 4 months after second vaccination. Antibody titers and neutralizing antibodies were measured. In our study, both antibody titers and neutralizing antibodies increased significantly at 5 weeks after first vaccination but decreased rapidly at 4 months after second vaccination. Additionally, the results showed a significant decrease regardless of gender or age. Further studies are needed to help determine the interval of SARS-CoV-2 vaccinations. MDPI 2021-10-08 /pmc/articles/PMC8539465/ /pubmed/34696253 http://dx.doi.org/10.3390/vaccines9101145 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Jo, Dong-Ho
Minn, Dohsik
Lim, Jaegyun
Lee, Ki-Deok
Kang, Yu-Min
Choe, Kang-Won
Kim, Kwang-Nam
Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination
title Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination
title_full Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination
title_fullStr Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination
title_full_unstemmed Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination
title_short Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination
title_sort rapidly declining sars-cov-2 antibody titers within 4 months after bnt162b2 vaccination
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539465/
https://www.ncbi.nlm.nih.gov/pubmed/34696253
http://dx.doi.org/10.3390/vaccines9101145
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