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TRANS-TACE: Prognostic Role of the Transient Hypertransaminasemia after Conventional Chemoembolization for Hepatocellular Carcinoma

The aim of the present study was to correlate laboratory data and postprocedural parameters after conventional transarterial chemoembolization (cTACE) for hepatocellular carcinoma (HCC) with the radiological response. The study consisted of a retrospective analysis of prospectively collected data fr...

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Autores principales: Granito, Alessandro, Facciorusso, Antonio, Sacco, Rodolfo, Bartalena, Laura, Mosconi, Cristina, Cea, Ugo Vittorio, Cappelli, Alberta, Antonino, Matteo, Modestino, Francesco, Brandi, Nicolò, Tovoli, Francesco, Piscaglia, Fabio, Golfieri, Rita, Renzulli, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539564/
https://www.ncbi.nlm.nih.gov/pubmed/34683182
http://dx.doi.org/10.3390/jpm11101041
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author Granito, Alessandro
Facciorusso, Antonio
Sacco, Rodolfo
Bartalena, Laura
Mosconi, Cristina
Cea, Ugo Vittorio
Cappelli, Alberta
Antonino, Matteo
Modestino, Francesco
Brandi, Nicolò
Tovoli, Francesco
Piscaglia, Fabio
Golfieri, Rita
Renzulli, Matteo
author_facet Granito, Alessandro
Facciorusso, Antonio
Sacco, Rodolfo
Bartalena, Laura
Mosconi, Cristina
Cea, Ugo Vittorio
Cappelli, Alberta
Antonino, Matteo
Modestino, Francesco
Brandi, Nicolò
Tovoli, Francesco
Piscaglia, Fabio
Golfieri, Rita
Renzulli, Matteo
author_sort Granito, Alessandro
collection PubMed
description The aim of the present study was to correlate laboratory data and postprocedural parameters after conventional transarterial chemoembolization (cTACE) for hepatocellular carcinoma (HCC) with the radiological response. The study consisted of a retrospective analysis of prospectively collected data from 70 consecutive patients who underwent cTACE. Laboratory parameters were assessed daily after cTACE and compared to pretreatment values. Post-treatment radiological response was assessed using mRECIST at one month from cTACE, and factors associated with treatment response (complete and objective response) were assessed by logistic regression analysis. The optimal cutoff points in predicting the complete response of target lesions were a 52% ALT and a 46% AST increase after cTACE compared to the pre-treatment values. Using multivariate analyses, >46% AST and >52% ALT increases with respect to the pre-treatment value were significantly correlated with the objective response (p = 0.03 and p = 0.04, respectively) and the complete response (p = 0.02 and p = 0.02, respectively). No patients experienced liver function deterioration after cTACE, and no specific treatment was required. This study showed that post-treatment transient transaminase elevation was predictive of objective response to superselective cTACE in clinical practice, representing a simple tool to guide treatment strategy of HCC patients in a tailored approach.
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spelling pubmed-85395642021-10-24 TRANS-TACE: Prognostic Role of the Transient Hypertransaminasemia after Conventional Chemoembolization for Hepatocellular Carcinoma Granito, Alessandro Facciorusso, Antonio Sacco, Rodolfo Bartalena, Laura Mosconi, Cristina Cea, Ugo Vittorio Cappelli, Alberta Antonino, Matteo Modestino, Francesco Brandi, Nicolò Tovoli, Francesco Piscaglia, Fabio Golfieri, Rita Renzulli, Matteo J Pers Med Article The aim of the present study was to correlate laboratory data and postprocedural parameters after conventional transarterial chemoembolization (cTACE) for hepatocellular carcinoma (HCC) with the radiological response. The study consisted of a retrospective analysis of prospectively collected data from 70 consecutive patients who underwent cTACE. Laboratory parameters were assessed daily after cTACE and compared to pretreatment values. Post-treatment radiological response was assessed using mRECIST at one month from cTACE, and factors associated with treatment response (complete and objective response) were assessed by logistic regression analysis. The optimal cutoff points in predicting the complete response of target lesions were a 52% ALT and a 46% AST increase after cTACE compared to the pre-treatment values. Using multivariate analyses, >46% AST and >52% ALT increases with respect to the pre-treatment value were significantly correlated with the objective response (p = 0.03 and p = 0.04, respectively) and the complete response (p = 0.02 and p = 0.02, respectively). No patients experienced liver function deterioration after cTACE, and no specific treatment was required. This study showed that post-treatment transient transaminase elevation was predictive of objective response to superselective cTACE in clinical practice, representing a simple tool to guide treatment strategy of HCC patients in a tailored approach. MDPI 2021-10-17 /pmc/articles/PMC8539564/ /pubmed/34683182 http://dx.doi.org/10.3390/jpm11101041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Granito, Alessandro
Facciorusso, Antonio
Sacco, Rodolfo
Bartalena, Laura
Mosconi, Cristina
Cea, Ugo Vittorio
Cappelli, Alberta
Antonino, Matteo
Modestino, Francesco
Brandi, Nicolò
Tovoli, Francesco
Piscaglia, Fabio
Golfieri, Rita
Renzulli, Matteo
TRANS-TACE: Prognostic Role of the Transient Hypertransaminasemia after Conventional Chemoembolization for Hepatocellular Carcinoma
title TRANS-TACE: Prognostic Role of the Transient Hypertransaminasemia after Conventional Chemoembolization for Hepatocellular Carcinoma
title_full TRANS-TACE: Prognostic Role of the Transient Hypertransaminasemia after Conventional Chemoembolization for Hepatocellular Carcinoma
title_fullStr TRANS-TACE: Prognostic Role of the Transient Hypertransaminasemia after Conventional Chemoembolization for Hepatocellular Carcinoma
title_full_unstemmed TRANS-TACE: Prognostic Role of the Transient Hypertransaminasemia after Conventional Chemoembolization for Hepatocellular Carcinoma
title_short TRANS-TACE: Prognostic Role of the Transient Hypertransaminasemia after Conventional Chemoembolization for Hepatocellular Carcinoma
title_sort trans-tace: prognostic role of the transient hypertransaminasemia after conventional chemoembolization for hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539564/
https://www.ncbi.nlm.nih.gov/pubmed/34683182
http://dx.doi.org/10.3390/jpm11101041
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