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The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers

The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so-called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, in...

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Autores principales: Freitas, Lucas F., Ferreira, Aryel H., Thipe, Velaphi C., Varca, Gustavo H. C., Lima, Caroline S. A., Batista, Jorge G. S., Riello, Fabiane N., Nogueira, Kamila, Cruz, Cassia P. C., Mendes, Giovanna O. A., Rodrigues, Adriana S., Sousa, Thayna S., Alves, Victoria M., Lugão, Ademar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539690/
https://www.ncbi.nlm.nih.gov/pubmed/34685018
http://dx.doi.org/10.3390/nano11102579
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author Freitas, Lucas F.
Ferreira, Aryel H.
Thipe, Velaphi C.
Varca, Gustavo H. C.
Lima, Caroline S. A.
Batista, Jorge G. S.
Riello, Fabiane N.
Nogueira, Kamila
Cruz, Cassia P. C.
Mendes, Giovanna O. A.
Rodrigues, Adriana S.
Sousa, Thayna S.
Alves, Victoria M.
Lugão, Ademar B.
author_facet Freitas, Lucas F.
Ferreira, Aryel H.
Thipe, Velaphi C.
Varca, Gustavo H. C.
Lima, Caroline S. A.
Batista, Jorge G. S.
Riello, Fabiane N.
Nogueira, Kamila
Cruz, Cassia P. C.
Mendes, Giovanna O. A.
Rodrigues, Adriana S.
Sousa, Thayna S.
Alves, Victoria M.
Lugão, Ademar B.
author_sort Freitas, Lucas F.
collection PubMed
description The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so-called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come from their optimal size, which prevents the elimination by the kidneys and enhances their permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore, the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the increased surface area and the selective accumulation in the desired tissues. This property leads to the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor. Finally, they are made so that there is no degradation into toxic byproducts and have a lower immune response triggering. In this article, we intend to review and discuss the state-of-the-art regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate cancer, as they are among the most prevalent worldwide.
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spelling pubmed-85396902021-10-24 The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers Freitas, Lucas F. Ferreira, Aryel H. Thipe, Velaphi C. Varca, Gustavo H. C. Lima, Caroline S. A. Batista, Jorge G. S. Riello, Fabiane N. Nogueira, Kamila Cruz, Cassia P. C. Mendes, Giovanna O. A. Rodrigues, Adriana S. Sousa, Thayna S. Alves, Victoria M. Lugão, Ademar B. Nanomaterials (Basel) Review The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so-called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come from their optimal size, which prevents the elimination by the kidneys and enhances their permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore, the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the increased surface area and the selective accumulation in the desired tissues. This property leads to the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor. Finally, they are made so that there is no degradation into toxic byproducts and have a lower immune response triggering. In this article, we intend to review and discuss the state-of-the-art regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate cancer, as they are among the most prevalent worldwide. MDPI 2021-09-30 /pmc/articles/PMC8539690/ /pubmed/34685018 http://dx.doi.org/10.3390/nano11102579 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Freitas, Lucas F.
Ferreira, Aryel H.
Thipe, Velaphi C.
Varca, Gustavo H. C.
Lima, Caroline S. A.
Batista, Jorge G. S.
Riello, Fabiane N.
Nogueira, Kamila
Cruz, Cassia P. C.
Mendes, Giovanna O. A.
Rodrigues, Adriana S.
Sousa, Thayna S.
Alves, Victoria M.
Lugão, Ademar B.
The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers
title The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers
title_full The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers
title_fullStr The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers
title_full_unstemmed The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers
title_short The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers
title_sort state of the art of theranostic nanomaterials for lung, breast, and prostate cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539690/
https://www.ncbi.nlm.nih.gov/pubmed/34685018
http://dx.doi.org/10.3390/nano11102579
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